Role of B7 signaling in the differentiation of naive CD4+ T cells to effector interleukin-4-producing T helper cells

Adhesion receptors of the immune system

1990 • 6,585 citations

IL-10 inhibits cytokine production by activated macrophages.

1991 • 2,919 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

1993 • 862 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes.

1992 • 395 citations

Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells.

1994 • 379 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

The Importance of Th2 Cytokines in Protective Immunity to Nematodes

1992 • 352 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni.

1993 • 337 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

1987 • 310 citations

The costimulatory function of antigen-presenting cells

1990 • 304 citations

The Biologic Roles of CD2, CD4, and CD8 in T-Cell Activation

1989 • 301 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Heat-stable antigen is a costimulatory molecule for CD4 T cell growth.

1992 • 254 citations

Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody.

1991 • 250 citations

Molecules involved in T-cell costimulation

1993 • 237 citations

Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.

1994 • 234 citations

Role of interleukin 1 in the activation of T lymphocytes.

1988 • 231 citations

A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3.

1993 • 226 citations

T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells.

1988 • 212 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.

1991 • 193 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

1992 • 138 citations

Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo.

1994 • 132 citations

The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells.

1992 • 125 citations

CD27 is a signal-transducing molecule involved in CD45RA+ naive T cell costimulation.

1994 • 120 citations

Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice

1991 • 119 citations

Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-_γ in CD4⁺ T cells

1993 • 119 citations

CD28-induced costimulation of T helper type 2 cells mediated by induction of responsiveness to interleukin 4.

1993 • 112 citations

CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite.

1994 • 111 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.

1992 • 95 citations

Heat‐stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function

1994 • 85 citations

A negative regulatory function of B7 revealed in B7-1 transgenic mice

1994 • 82 citations

Differential regulatory effects of intercellular adhesion molecule-1 on costimulation by the CD28 counter-receptor B7.

1992 • 78 citations

T cell co-stimulation and in vivo tolerance

1993 • 77 citations

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

1995 • 70 citations

Polyclonal activation of the murine immune system by an antibody to IgD. I. Increase in cell size and DNA synthesis.

1982 • 54 citations

Production of BSF-1 during an in vivo, T-dependent immune response.

1986 • 51 citations

Restriction factors of homologous complement: A new candidate?

1990 • 48 citations

Requirement of CTLA-4 counter receptors for IL-4 but not IL-10 elevations during a primary systemic in vivo immune response.

1995 • 45 citations

Role of IL-6, IL-1, and CD28 signaling in responses of mouse CD4+ T cells to immobilized anti-TCR monoclonal antibody.

1994 • 39 citations

FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line.

1991 • 34 citations

Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction.

1994 • 32 citations

Co-Stimulatory Functions of Antigen-Presenting Cells

1992 • 18 citations

In vivo and in vitro expression of an interleukin 2 receptor by murine B and T lymphocytes.

1986 • 16 citations

Polyclonal activation of the murine immune system by an antibody to IgD. VI. Influence of doses of goat anti‐mouse δ chain and normal goat IgG on B lymphocyte proliferation and differentiation

1985 • 11 citations

Deleted Work

1955 • 0 citations