Promoter suppression in cultured mammalian cells can be blocked by the chicken β-globin chromatin insulator 5′HS4 and matrix/scaffold attachment regions11Edited by M. Yaniv

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

Human gene therapy comes of age

1992 • 927 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: Identification of an upstream control region

1981 • 646 citations

DNA methylation and chromatin modification

1999 • 641 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

1984 • 440 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

1996 • 418 citations

Biological Significance of Unwinding Capability of Nuclear Matrix-Associating DNAs

1992 • 407 citations

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

1998 • 403 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

Position Effects on Eukaryotic Gene Expression

1990 • 377 citations

Regulation of gene expression by alternative promoters

1996 • 374 citations

Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

1984 • 368 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1992 • 319 citations

Transcriptional interference and termination between duplicated α-globin gene constructs suggests a novel mechanism for gene regulation

1986 • 312 citations

Promoter occlusion: Transcription through a promoter may inhibit its activity

1982 • 294 citations

The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.

1990 • 276 citations

HUMAN GENE THERAPY

1993 • 262 citations

Gene therapy for cancer

1994 • 244 citations

Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12.

1979 • 238 citations

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

1991 • 235 citations

Conspiracy of silence among repeated transgenes

1998 • 231 citations

The enhancer of the immunoglobulin heavy chain locus is flanked by presumptive chromosomal loop anchorage elements.

1987 • 229 citations

Stopped at the border: boundaries and insulators

1999 • 222 citations

Loss of Insulator Activity by Paired Su(Hw) Chromatin Insulators

2001 • 209 citations

Effects of cis Arrangement of Chromatin Insulators on Enhancer-Blocking Activity

2001 • 193 citations

On spacers

1979 • 159 citations

Quantitative analysis of gene suppression in integrated retrovirus vectors.

1986 • 155 citations

Putting Boundaries on Silence

1999 • 149 citations

The prokaryotic neomycin-resistance-encoding gene acts as a transcriptional silencer in eukaryotic cells

1991 • 139 citations

Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch

1989 • 138 citations

Positions of Potential:Nuclear Organization and Gene Expression

2001 • 134 citations

Unusual DNA structures, chromatin and transcription

1994 • 129 citations

Position-Independent Transgene Expression Mediated by Boundary Elements from the Apolipoprotein B Chromatin Domain

1995 • 128 citations

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy.

1993 • 125 citations

Promoter occlusion during ribosomal RNA transcription

1988 • 123 citations

Effects of the position of the simian virus 40 enhancer on expression of multiple transcription units in a single plasmid.

1986 • 118 citations

Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element.

1990 • 112 citations

Local domains of supercoiling activate a eukaryotic promoter in vivo

1993 • 110 citations

Dividing the empire: boundary chromatin elements delimit the territory of enhancers

1999 • 103 citations

Human Matrix Attachment Regions Insulate Transgene Expression from Chromosomal Position Effects in Drosophila melanogaster

1998 • 96 citations

Comparison of promoter suppression in avian and murine retrovirus vectors

1986 • 95 citations

Sequences required for enhancer blocking activity of scs are located within two nuclease-hypersensitive regions.

1994 • 92 citations

A Nuclear Matrix/Scaffold Attachment Region Co-localizes with the Gypsy Retrotransposon Insulator Sequence

1998 • 85 citations

Genetic evidence for promoter competition in Saccharomyces cerevisiae.

1988 • 67 citations

Position effects and genetic disease

1996 • 66 citations

The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing

1999 • 63 citations

The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expression

1982 • 63 citations

Scaffold attachments within the human genome

1997 • 49 citations

The Activity of the scs and scs’ Insulator Elements Is Not Dependent on Chromosomal Context

1997 • 40 citations

Maize Spm transposable element has an enhancer-insensitive promoter.

1993 • 38 citations

The Repeat Organizer, a Specialized Insulator Element within the Intergenic Spacer of the Xenopus rRNA Genes

1997 • 37 citations

Enhancer blocking activity located near the 3′ end of the sea urchin early H2A histone gene

1997 • 36 citations

Phenotypic Variation Associated with Molecular Alterations at a Cluster of Thymidine Kinase Genes

1983 • 18 citations

Interference of DNA sequence divergence with precise recombinational DNA repair in mammalian cells.

1994 • 16 citations

Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes.

1983 • 13 citations

Long-range activation of transcription by SV40 enhancer is affected by ?inhibitory? or ?permissive? DNA sequences between enhancer and promoter

1989 • 11 citations