Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

1994 • 856 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells

1994 • 618 citations

Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2

1994 • 598 citations

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

1996 • 483 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

IRS-1: Essential for Insulin- and IL-4-Stimulated Mitogenesis in Hematopoietic Cells

1993 • 401 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Cloning of Murine Stat6 and Human Stat6, Stat Proteins That Are Tyrosine Phosphorylated in Responses to IL-4 and IL-3 but Are Not Required for Mitogenesis

1995 • 325 citations

DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.

1996 • 302 citations

Naturally Occurring Dominant Negative Variants of Stat5

1996 • 270 citations

Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response

1996 • 260 citations

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

1991 • 259 citations

Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4

1993 • 256 citations

Components of a stat recognition code: Evidence for two layers of molecular selectivity

1995 • 254 citations

B cell growth-promoting activity of recombinant human interleukin 4.

1987 • 211 citations

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells.

1992 • 191 citations

STF-IL-4: a novel IL-4-induced signal transducing factor.

1994 • 183 citations

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1993 • 173 citations

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 Receptor

1996 • 158 citations

Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1

1996 • 153 citations

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression.

1988 • 145 citations

Interleukin 4 receptor: signaling mechanisms

1994 • 131 citations

Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines.

1987 • 117 citations

Interleukin 4 signals through two related pathways.

1995 • 90 citations

Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2

1993 • 76 citations

Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts

1996 • 75 citations

Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-γ and interleukin-4 receptor-α

1996 • 59 citations

Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.

1993 • 43 citations

Inhibition of oncogene-mediated transformation by ectopic expression of p21Waf1 in NIH3T3 cells.

1996 • 32 citations

Modulation of the Fc gamma RII and Fc gamma RIII induced by GM-CSF, IFN-gamma and IL-4 on murine eosinophils.

1994 • 14 citations

Interaction Between Nf-κB- and Serum Response Factor-Binding Elements Activates an Interleukin-2 Receptor α-Chain Enhancer Specifically in T Lymphocytes

1993 • 11 citations