Replication of human immunodeficiency virus-1 in primary human T cells is dependent on the autocrine secretion of tumor necrosis factor through the control of nuclear factor-κB activation

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

Multifactorial Nature of Human Immunodeficiency Virus Disease: Implications for Therapy

1993 • 803 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.

1989 • 726 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

Quiescent T Lymphocytes as an Inducible Virus Reservoir in HIV-1 Infection

1991 • 584 citations

Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen.

1985 • 545 citations

Tumor necrosis factor alpha functions in an autocrine manner in the induction of human immunodeficiency virus expression.

1990 • 471 citations

Cellular Transcription Factors Involved in the Regulation of HIV-1 Gene Expression

1992 • 341 citations

Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor

1989 • 331 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Serum Levels of Tumor Necrosis Factor- (TNF ) and Soluble TNF Receptors in Human Immunodeficiency Virus Type 1 Infection-Correlations to Clinical, Immunologic, and Virologic Parameters

1994 • 302 citations

Immunopathogenic mechanisms of HIV infection: cytokine induction of HIV expression

1990 • 290 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

1995 • 233 citations

Production of tumor necrosis factor/cachectin by human T cell lines and peripheral blood T lymphocytes stimulated by phorbol myristate acetate and anti-CD3 antibody.

1988 • 187 citations

HIV enhancer activity perpetuated by NF-κB induction on infection of monocytes

1991 • 186 citations

Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus.

1989 • 172 citations

Macrophages and the human immunodeficiency virus

1990 • 169 citations

Cytokine modulation of HIV expression

1993 • 147 citations

Tumour necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication

1990 • 145 citations

HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines.

1995 • 144 citations

Inhibition of HIV progression by dithiocarb

1990 • 126 citations

Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donors.

1991 • 124 citations

Simultaneous production of tumor necrosis factor-alpha and lymphotoxin by normal T cells after induction with IL-2 and anti-T3.

1988 • 98 citations

Tumor necrosis factor-alpha activation of the IL-2 receptor-alpha gene involves the induction of kappa B-specific DNA binding proteins.

1989 • 98 citations

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription

1992 • 98 citations

Physiologic activation of T cells via the T cell receptor induces NF-kappa B.

1991 • 95 citations

Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription.

1990 • 93 citations

Control of T lymphocyte activation and IL-2 receptor expression by endogenously secreted lymphokines.

1994 • 78 citations

The Role of Monocyte/Macrophages and Cytokines in the Pathogenesis of HIV Infection

1992 • 75 citations

Regulation of HIV-1 expression by cytokine networks in a CD4+ model of chronic infection.

1993 • 63 citations

Regulation of Human Immunodeficiency Virus Infection: Implications For Pathogenesis

1994 • 61 citations

A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter

1995 • 55 citations

Biphasic control of nuclear factor‐χB activation by the T cell receptor complex: role of tumor necrosis factor α

1995 • 38 citations

Pentoxifylline for the Treatment of Infection with Human Immunodeficiency Virus

1994 • 37 citations

Pentoxifylline inhibits acute HIV-1 replication in human T cells by a mechanism not involving inhibition of tumour necrosis factor synthesis or nuclear factor-κB activation

1996 • 35 citations

Deleted Work

1955 • 0 citations