Interleukin-4 and breast cancer

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.

1992 • 838 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

A novel family of growth factor receptors: A common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor β-chain

1989 • 551 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

1990 • 430 citations

High Frequency of IL-4–Producing CD4+ Allergen-Specific T Lymphocytes in Atopic Dermatitis Lesional Skin

1991 • 397 citations

Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells

1988 • 263 citations

Inhibition of Angiogenesis by Interleukin 4

1998 • 254 citations

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

1988 • 244 citations

Regulation of IgG1 and IgE Production by Interleukin 4

1988 • 244 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor

1987 • 193 citations

Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.

1993 • 175 citations

Inhibition of colon and breast carcinoma cell growth by interleukin-4.

1992 • 169 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

The effects of gonadotrophin releasing hormone analogues in prostate cancer are mediated through specific tumour receptors

1990 • 156 citations

Restricted production of interleukin 4 by activated human T cells.

1988 • 141 citations

Characterization of the high-affinity cell-surface receptor for murine B-cell-stimulating factor 1.

1987 • 140 citations

An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.

1994 • 130 citations

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1994 • 127 citations

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1990 • 119 citations

Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.

1987 • 116 citations

Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells.

1998 • 108 citations

Role of neutrophils and lymphocytes in inhibition of a mouse mammary adenocarcinoma engineered to release IL-2, IL-4, IL-7, IL-10, IFN-alpha, IFN-gamma, and TNF-alpha.

1996 • 103 citations

Induction of 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4 Isomerase Type 1 Gene Transcription in Human Breast Cancer Cell Lines and in Normal Mammary Epithelial Cells by Interleukin-4 and Interleukin-13

1999 • 77 citations

High affinity binding of human interleukin 4 to cell lines

1987 • 70 citations

Phase II Studies of Recombinant Human Interleukin-4 in Advanced Renal Cancer and Malignant Melanoma

1994 • 67 citations

IL-4/B cell stimulatory factor 1 stimulates T cell growth by an IL-2-independent mechanism.

1988 • 62 citations

Recombinant human interleukin-4 inhibits growth of some human lung tumor cell lines in vitro and in vivo

1993 • 59 citations

Interleukin-4 and interleukin-13 inhibit estrogen-induced breast cancer cell proliferation and stimulate GCDFP-15 expression in human breast cancer cells

1996 • 58 citations

The paracrine role of tumour-derived mIL-4 on tumour-associated endothelium

1997 • 54 citations

Recombinant human interleukin 4 has antiproliferative activity on human tumor cell lines derived from epithelial and nonepithelial histologies.

1995 • 52 citations

Phase II Trial of Recombinant Human Interleukin-4 in Patients with Disseminated Malignant Melanoma

1998 • 47 citations

Enhancement of human IL-4 activity by soluble IL-4 receptorsin vitro

1999 • 36 citations

Interleukin 4 potentiates the antiproliferative effects of tumor necrosis factor on various tumor cell lines.

1991 • 36 citations

A phase II study of subcutaneous recombinant human lnterleukjn-4 in metastatic renal cell carcinoma

1995 • 35 citations

Regulation of sex steroid formation by interleukin-4 and interleukin-6 in breast cancer cells

1998 • 35 citations

A phase II study of recombinant human interleukin-4 for advanced or recurrent non-small cell lung cancer.

1998 • 23 citations

Soluble Human Interleukin–4 Receptor Is Produced by Activated T Cells under the Control of Metalloproteinases

1999 • 21 citations

Development and Characterization of an IL-4-Secreting Human Ovarian Carcinoma Cell Line

1995 • 21 citations

Immunostaining of interleukin-4 receptor on human renal cell carcinoma.

1993 • 20 citations

Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast

1996 • 17 citations

Tumour-associated upregulation of the IL-4 receptor complex.

1990 • 15 citations

Detection of and discrimination between total and free human interleukin-4 and free soluble interleukin-4 receptor by ELISA

1998 • 14 citations

Interleukin-2 and interleukin-4 display potent antitumour activity on rat medullary thyroid carcinoma cells

1995 • 11 citations

Loss of interleukin 4 receptor-associated molecule gp200-MR6 in human breast cancer: prognostic significance

1996 • 8 citations

Growth-independent induction of spermidine transport by IL-4 and IL-13 in ZR-75-1 human breast cancer cells

1996 • 7 citations

Loss of tumorigenicity of human breast cancer cells engineered to produce IL-2, IL-4 or GM-CSF in nude mice.

1999 • 3 citations

Paracrine effects of IL- 4 transfection on TS/A adenocarcinoma cells mediate reducedin Vivo growth

1999 • 3 citations