A phase II study of subcutaneous recombinant human lnterleukjn-4 in metastatic renal cell carcinoma

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

An Eosinophil-Dependent Mechanism for the Antitumor Effect of Interleukin-4

1992 • 540 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4.

1993 • 175 citations

Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy.

1992 • 89 citations

Gene Therapy of Cancer: A Pilot Study of IL-4-Gene-Modified Fibroblasts Admixed with Autologous Tumor to Elicit an Immune Response. University of Pittsburgh

1994 • 74 citations

Phase II Studies of Recombinant Human Interleukin-4 in Advanced Renal Cancer and Malignant Melanoma

1994 • 67 citations

Recombinant human IL-4 induces IgE and IgG synthesis by normal and atopic donor mononuclear cells. Similar dose response, time course, requirement for T cells, and effect of pokeweed mitogen.

1990 • 66 citations

Interleukin 4 alone and with gamma-interferon or alpha-tumor necrosis factor inhibits cell growth and modulates cell surface antigens on human renal cell carcinomas.

1991 • 64 citations

Possible Myocardial Toxicity Associated with Interleukin-4 Therapy

1993 • 28 citations

A phase I study of recombinant human interleukin-4 administered by the intravenous and subcutaneous route in patients with advanced cancer: immunological studies.

1993 • 14 citations

Intralesional Treatment of Established Murine Primary Renal Tumor With Interleukin-4: Localized Effect on Primary Tumor With no Impact on Metastases

1995 • 11 citations