Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus

The Mouse Brain in Stereotaxic Coordinates

2001 • 12,804 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

mouse brain in stereotaxic coordinates

1997 • 3,077 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

1999 • 1,055 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

2005 • 593 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment

1995 • 536 citations

Use-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors

1997 • 469 citations

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

1997 • 389 citations

LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors

1998 • 360 citations

Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2

1996 • 342 citations

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

2001 • 338 citations

Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs

2001 • 310 citations

Distribution of urocortin-like immunoreactivity in the central nervous system of the rat

1998 • 256 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 • 248 citations

Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

1998 • 217 citations

The Neurobiology of Conditioned and Unconditioned Fear: A Neurobehavioral System Analysis of the Amygdala

2004 • 216 citations

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

2003 • 208 citations

Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol

1997 • 194 citations

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

2003 • 187 citations

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

2004 • 158 citations

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

2003 • 144 citations

Modulation of the intracellular calcium concentration in photoreceptor terminals by a presynaptic metabotropic glutamate receptor

1999 • 122 citations

Chronic Administration of the Triazolobenzodiazepine Alprazolam Produces Opposite Effects on Corticotropin-Releasing Factor and Urocortin Neuronal Systems

2000 • 121 citations

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039

2004 • 116 citations

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice

2004 • 115 citations

Anxiolytic Activity of the MGLU2/3 Receptor Agonist LY354740 on the Elevated Plus Maze is Associated with the Suppression of Stress-Induced c-Fos in the Hippocampus and Increases in c-Fos Induction in Several Other Stress-Sensitive Brain Regions

2003 • 103 citations

Preclinical Pharmacology of mGlu2 / 3 Receptor Agonists: Novel Agents for Schizophrenia?

2002 • 102 citations

[3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.

2001 • 97 citations

Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

2000 • 94 citations

The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration

2001 • 93 citations

Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing

2005 • 88 citations

Cocaine and Kindling Alter the Sensitivity of Group II and III Metabotropic Glutamate Receptors in the Central Amygdala

2000 • 77 citations

Anti-epileptic activity of group II metabotropic glutamate receptor agonists (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (−)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795)

2001 • 58 citations

Differential regulation of synaptic transmission by mGlu2 and mGlu3 at the perforant path inputs to the dentate gyrus and CA1 revealed in mGlu2 -/- mice

2002 • 58 citations

Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala1Published on the World Wide Web on 27 May 1998.1

1998 • 52 citations

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

2002 • 49 citations

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

2002 • 47 citations

Fast Fos: rapid protocols for single- and double-labeling c-Fos immunohistochemistry in fresh frozen brain sections

2004 • 44 citations

Comparison of c-Fos induction in the brain by the mGlu2/3 receptor antagonist LY341495 and agonist LY354740: Evidence for widespread endogenous tone at brain mGlu2/3 receptors in vivo

2005 • 35 citations

Chlordiazepoxide‐Induced Expression of c‐Fos in the Central Extended Amygdala and Other Brain Regions of the C57BL/6J and DBA/2J Inbred Mouse Strains: Relationships to Mechanisms of Ethanol Action

1999 • 34 citations

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine‐induced down‐regulation of β‐adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands

2005 • 31 citations

Cells in midline thalamus, central amygdala, and nucleus accumbens responding specifically to antipsychotic drugs

2003 • 30 citations

cFos labeling in rat superior colliculus: Activation by normal retinal pathways and pathways from intracranial retinal transplants

1992 • 30 citations

The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis

2004 • 28 citations

LY3 54740: A Systemically Active mGlu2/mGlu3 Receptor Agonist

1999 • 28 citations

Presynaptic Group II mGluR Inhibition of Short-Term Depression in the Medial Perforant Path of the Dentate Gyrus In Vitro

2001 • 27 citations

Activation of Group II and Group III metabotropic glutamate receptors by endogenous ligand(s) and the modulation of synaptic transmission in the superficial superior colliculus

2004 • 13 citations

Metabotropic glutamate (mGlu) receptors and nociceptive processing

2001 • 7 citations