Back to search

A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala

Data up to Jan 2025

Published2001
Citations339
References50

Total Citations Per Year

Abstract

References (50)

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The MAPK signaling cascade

1995 • 3,300 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Fear conditioning induces associative long-term potentiation in the amygdala

1997 • 1,285 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning

1990 • 1,134 citations

The neuroanatomical and neurochemical basis of conditioned fear

1999 • 1,092 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

Cross Talk between ERK and PKA Is Required for Ca2+ Stimulation of CREB-Dependent Transcription and ERK Nuclear Translocation

1998 • 885 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Neurotransmission in the rat amygdala related to fear and anxiety

1994 • 781 citations

Fear conditioning induces a lasting potentiation of synaptic currents in vitro

1997 • 772 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Fear-potentiated startle: A neural and pharmacological analysis

1993 • 736 citations

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

1997 • 671 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Activation of ERK/MAP Kinase in the Amygdala Is Required for Memory Consolidation of Pavlovian Fear Conditioning

2000 • 660 citations

Memory Consolidation of Auditory Pavlovian Fear Conditioning Requires Protein Synthesis and Protein Kinase A in the Amygdala

2000 • 594 citations

Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons

1998 • 577 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus

1999 • 542 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

1999 • 520 citations

Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats

1997 • 500 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Long-term potentiation in the amygdala: a mechanism for emotional learning and memory

1999 • 445 citations

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

2001 • 441 citations

Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear- potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli

1995 • 382 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Postsynaptic Induction and PKA-Dependent Expression of LTP in the Lateral Amygdala

1998 • 332 citations

Specific and Differential Activation of Mitogen-Activated Protein Kinase Cascades by Unfamiliar Taste in the Insular Cortex of the Behaving Rat

1998 • 289 citations

Both Protein Kinase A and Mitogen-Activated Protein Kinase Are Required in the Amygdala for the Macromolecular Synthesis-Dependent Late Phase of Long-Term Potentiation

2000 • 275 citations

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

1999 • 262 citations

L-Type Voltage-Gated Calcium Channels Mediate NMDA-Independent Associative Long-Term Potentiation at Thalamic Input Synapses to the Amygdala

1999 • 250 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

Ca2+-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

1999 • 197 citations

Involvement of hippocampal D1/D5 receptor-cAMP signaling pathways in a late memory consolidation phase of an aversively-motivated task in rats

1997 • 188 citations

Receptors of the Glial Cell Line-Derived Neurotrophic Factor Family of Neurotrophic Factors Signal Cell Survival through the Phosphatidylinositol 3-Kinase Pathway in Spinal Cord Motoneurons

1999 • 173 citations

Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin

2000 • 147 citations

The design and calibration of a startle measurement system

1986 • 140 citations

P42/44 MAP Kinase Inhibitor PD98059 Attenuates Multiple Forms of Synaptic Plasticity in Rat Dentate Gyrus In Vitro

1999 • 140 citations

The Extracellular Signal-Regulated Kinase Cascade Is Required for NMDA Receptor-Independent LTP in Area CA1 But Not Area CA3 of the Hippocampus

2000 • 110 citations

The amygdala: contributions to fear and stress

1994 • 103 citations

Enhanced Hippocampal CA1 LTP but Normal Spatial Learning in Inositol 1,4,5-trisphosphate 3-kinase(A)-Deficient Mice

1998 • 84 citations

Involvement of mitogen-activated protein kinase in hippocampal long-term potentiation

1999 • 42 citations

Cited By (0)

Loading...
A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity… (2001) – Neuron | Metascience Observatory Explorer