The influence of the src‐family kinases, Lck and Fyn, on T cell differentiation, survival and activation

CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES

1997 • 2,470 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

T-cell development and the CD4–CD8 lineage decision

2002 • 738 citations

A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

1998 • 720 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

Maintaining the norm: T-cell homeostasis

2002 • 608 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Population Biology of Lymphocytes: The Flight for Survival

2000 • 439 citations

THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation

1999 • 439 citations

Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells

1991 • 417 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Src Family Tyrosine Kinases and Growth Factor Signaling

2000 • 391 citations

The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics

2001 • 390 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

2000 • 194 citations

Proximal protein tyrosine kinases in immunoreceptor signaling

2001 • 189 citations

Distinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytes.

1994 • 180 citations

Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif

1994 • 179 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

1997 • 165 citations

TCR and IL-7 Receptor Signals Can Operate Independently or Synergize to Promote Lymphopenia-Induced Expansion of Naive T Cells

2002 • 160 citations

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.

1997 • 160 citations

p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.

1994 • 159 citations

Survival and Homeostatic Proliferation of Naive Peripheral CD4+ T Cells in the Absence of Self Peptide:MHC Complexes

2000 • 156 citations

CD4+ T cell survival is not directly linked to self-MHC–induced TCR signaling

2000 • 156 citations

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

2002 • 154 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src

1997 • 144 citations

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

2000 • 143 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor β-chain genes

1993 • 130 citations

TCR Signals Mediated by Src Family Kinases Are Essential for the Survival of Naive T Cells

2002 • 121 citations

Long-Term Survival But Impaired Homeostatic Proliferation of Naïve T Cells in the Absence of p56 ^lck

2000 • 120 citations

Cutting Edge: Fyn Is Essential for Tyrosine Phosphorylation of Csk-Binding Protein/Phosphoprotein Associated with Glycolipid-Enriched Microdomains in Lipid Rafts in Resting T Cells

2002 • 120 citations

Peripheral T cell survival

1999 • 116 citations

Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn

2000 • 110 citations

A functional complex is formed in human T lymphocytes between the protein tyrosine phosphatase CD45, the protein tyrosine kinase p56^lck and pp³², a possible common substrate

1991 • 104 citations

Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling

1997 • 103 citations

Differential Survival of Naive CD4 and CD8 T Cells

2000 • 98 citations

Molecular Interaction between the Fyn-associated Protein SKAP55 and the SLP-76-associated Phosphoprotein SLAP-130

1998 • 94 citations

SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction

1996 • 92 citations

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.

1992 • 91 citations

Expression and Interactions of the Src Family of Tyrosine Protein Kinases in T Lymphocytes

1991 • 83 citations

LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck.

1995 • 80 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development

1994 • 75 citations

Specific Association of Tyrosine-phosphorylated c-Cbl with Fyn Tyrosine Kinase in T Cells

1996 • 75 citations

A Physical Interaction between the Cell Death Protein Fas and the Tyrosine Kinase p59

1996 • 73 citations

Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines.

1995 • 72 citations

Lad, an Adapter Protein Interacting with the SH2 Domain of p56lck, Is Required for T Cell Activation

1999 • 71 citations

Selective Activation of T Cell Kinase p56 by Herpesvirus saimiri Protein Tip

1996 • 69 citations

Ras GTPase-activating protein: a substrate and a potential binding protein of the protein-tyrosine kinase p56lck.

1992 • 66 citations

Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association

1993 • 63 citations

CD3 Ligation on Immature Thymocytes Generates Antagonist-like Signals Appropriate for CD8 Lineage Commitment, Independently of T Cell Receptor Specificity

1998 • 59 citations

Demonstration of a Direct Interaction between p56 and the Cytoplasmic Domain of CD45 in Vitro

1996 • 57 citations

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

1992 • 55 citations

Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus

1997 • 51 citations

Commitment to the CD4 Lineage Mediated by Extracellular Signal-Related Kinase Mitogen-Activated Protein Kinase and Lck Signaling

1999 • 49 citations

The Lck SH3 Domain Negatively Regulates Localization to Lipid Rafts through an Interaction with c-Cbl

2002 • 48 citations

Physical and functional interactions of protein tyrosine kinases, p59fyn and ZAP-70, in T cell signaling.

1996 • 46 citations

Autonomous Maturation of α/β T Lineage Cells in the Absence of Cooh-Terminal Src Kinase (Csk)

2001 • 45 citations

Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization.

1996 • 41 citations

Positive and Negative Selection of Thymocytes Depends on Lck Interaction with the CD4 and CD8 Coreceptors

2001 • 39 citations

Positive and negative regulation of leukocyte activation by protein tyrosine phosphatases

1995 • 36 citations

Molecular requirements for lineage commitment in the thymus – antibody‐mediated receptor engagements reveal a central role for lck in lineage decisions

1998 • 31 citations

Lck plays a critical role in Ca2+ mobilization and CD28 costimulation in mature primary T cells

2001 • 31 citations

Association between Mitogen-activated Protein Kinase and the ζ Chain of the T Cell Receptor (TcR) with the SH2,3 Domain of p56lck

1996 • 30 citations

A crystal milestone: The structure of regulated Src

1997 • 28 citations

T Cells Expressing Receptors of Different Affinity for Antigen Ligands Reveal a Unique Role for p59fynin T Cell Development and Optimal Stimulation of T Cells by Antigen

1998 • 27 citations

Activation of T Cell Raf-1 at Mitosis Requires the Protein-tyrosine Kinase Lck

1996 • 25 citations

The cysteine residues in the cytoplasmic tail of CD8 α are required for its coreceptor function

1993 • 20 citations

Lck Domains Differentially Contribute to Pre–T Cell Receptor (Tcr)–And TCR-α/β–Regulated Developmental Transitions

2000 • 18 citations

Differences in Binding of PI 3-Kinase to the src-Homology Domains 2 and 3 of p56 lck and p59 fyn Tyrosine Kinases

1996 • 16 citations

Differential Requirement for p56lck in Fetal and Adult Thymopoiesis

1998 • 14 citations

CD28-induced cytokine production and proliferation by thymocytes are differentially regulated by the p59fyn tyrosine kinase.

1997 • 4 citations