Serologic mapping and biochemical characterization of the carcinoembryonic antigen epitopes using fourteen distinct monoclonal antibodies

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

Deglycosylation of glycoproteins by trifluoromethanesulfonic acid

1981 • 728 citations

The amino-acid sequence in the phenylalanyl chain of insulin. 2. The investigation of peptides from enzymic hydrolysates

1951 • 492 citations

Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy

1981 • 377 citations

Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence

1987 • 259 citations

Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.

1983 • 256 citations

Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

1987 • 223 citations

Immunoscintigraphy of colon carcinoma.

1984 • 209 citations

Detection of colorectal carcinoma by emission-computerized tomography after injection of 123I-labeled Fab or F(ab')2 fragments from monoclonal anti-carcinoembryonic antigen antibodies.

1986 • 191 citations

Definition by monoclonal antibodies of a repertoire of epitopes on carcinoembryonic antigen differentially expressed in human colon carcinomas versus normal adult tissues.

1985 • 177 citations

The covalent structure of a human γG-immunoglobulin. II. Isolation and characterization of the cyanogen bromide fragments

1968 • 172 citations

The Carcinoembryonic Antigen Gene Family: Structure, Expression and Evolution

1988 • 156 citations

Monoclonal antibodies identify a cea crossreacting antigen of 95 kD (NCA‐95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 kD

1984 • 151 citations

Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.

1988 • 150 citations

Basic principles and applications of monoclonal antibodies in the management of carcinomas: the Richard and Hinda Rosenthal Foundation award lecture.

1986 • 148 citations

Monoclonal antibodies specific for carcinoembryonic antigen and produced by two hybrid cell lines.

1980 • 146 citations

Immunological heterogeneity of carcinoembryonic antigen: antigenic determinants on carcinoembryonic antigen distinguished by monoclonal antibodies.

1983 • 139 citations

Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.

1988 • 127 citations

Influence of spatial configuration of carcinoma cell populations on the expression of a tumor-associated glycoprotein.

1985 • 125 citations

Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts.

1984 • 122 citations

Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: a systematic approach for the determination of epitope specificities of monoclonal antibodies.

1983 • 121 citations

Preoperative imaging of colorectal carcinoma with 111In-labeled anticarcinoembryonic antigen monoclonal antibody.

1986 • 111 citations

Monoclonal antibodies for carcinoembryonic antigen and related antigens as a model system: determination of affinities and specificities of monoclonal antibodies by using biotin-labeled antibodies and avidin as precipitating agent in a solution phase immunoassay.

1983 • 107 citations

Purification and characterization of carcinoembryonic antigen-related antigens in normal adult feces.

1981 • 101 citations

Clinical applications of carcinoembryonic antigen.

1988 • 95 citations

Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors.

1988 • 90 citations

Differential Binding to Human Mammary and Nonmammary Tumors of Monoclonal Antibodies Reactive with Carcinoembryonic Antigen

1983 • 79 citations

Radioimmunotherapy of human colonic cancer xenografts with 90Y labeled monoclonal antibodies to carcinoembryonic antigen.

1988 • 79 citations

Monoclonal antibody against carcinoembryonic antigen (CEA) identifies two new forms of crossreacting antigens of molecular weight 90,000 and 160,000 in normal granulocytes

1987 • 79 citations

Localisation of metastatic carcinoma by a radiolabelled monoclonal antibody

1983 • 72 citations

Radioimmunotherapy of the GW-39 human colonic tumor xenograft with 131I-labeled murine monoclonal antibody to carcinoembryonic antigen.

1987 • 67 citations

Monoclonal antibodies to carcinoembryonic antigen: a systematic analysis of antibody specificities by using related normal antigens and evidence for allotypic determinants on carcinoembryonic antigen.

1984 • 67 citations

TWO CEA AND THREE NCA SPECIES, ALTHOUGH DISTINGUISHABLE BY MONOCLONAL ANTIBODIES, HAVE NEARLY IDENTICAL PEPTIDE PATTERNS

1985 • 63 citations

Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical, histopathologic, and immunohistochemical findings.

1988 • 62 citations

Immunological heterogeneity of carcinoembryonic antigen: immunohistochemical detection of carcinoembryonic antigen determinants in colonic tumors with monoclonal antibodies.

1983 • 60 citations

Mapping epitope characteristics on carcinoembryonic antigen

1986 • 59 citations

A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas.

1983 • 53 citations

Immunochemical differences among carcinoembryonic antigen in tumor tissues and related antigens in meconium and adult feces.

1982 • 51 citations

Epitopes of carcinoembryonic antigen defined by monoclonal antibodies prepared from mice immunized with purified carcinoembryonic antigen or HCT-8R cells.

1986 • 44 citations

Immunoscintigraphy of colorectal carcinoma with F (ab')2 fragments of anti-CEA monoclonal antibody.

1987 • 43 citations

Comparison of tumor targeting of mouse monoclonal and goat polyclonal antibodies to carcinoembryonic antigen in the GW-39 human tumor-hamster host model.

1988 • 37 citations

Immunological characterization and structural studies of normal fecal antigen-1 related to carcinoembryonic antigen

1982 • 37 citations

Epitope mapping of the carcinoembryonic antigen by monoclonal antibodies and establishment of a new improved radioimmunoassay system.

1987 • 35 citations

Idiotype‐anti‐idiotype interactions and the control of the anti‐β(2→6) polyfructosan response in the mouse: specificity and idiotypy of anti‐ABPC48 anti‐idiotypic monoclonal antibodies

1981 • 34 citations

Differential expression of carcinoembryonic antigen in early gastric adenocarcinomas versus benign gastric lesions defined by monoclonal antibodies reactive with restricted antigen epitopes.

1987 • 30 citations

Coproduction of Carcinoembryonic Antigen and Nonspecific Cross-Reacting Antigen by a Continuous Cell Line From a Human Pancreatic Tumor<xref ref-type="fn" rid="fn2">2</xref>

1982 • 29 citations

Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA

1986 • 23 citations

Antigenic heterogeneity of carcinoembryonic antigen in the circulation defined by monoclonal antibodies against the carbohydrate moiety of carcinoembryonic antigen and closely related antigens.

1987 • 23 citations

Antigenic reactivities of purified preparations of carcinoembryonic antigen (CEA) and related normal antigens using four different radioimmunoassay systems for CEA

1983 • 22 citations

Epitope specificity and cross-reactivity pattern of a large series of monoclonal antibodies to carcinoembryonic antigen

1986 • 18 citations

Adjunct to the diagnostic distinction between adenocarcinomas of the ovary and the colon utilizing a monoclonal antibody (COL-4) with restricted carcinoembryonic antigen reactivity.

1987 • 17 citations

Identification and partial characterization of the unglycosylated peptide of carcinoembryonic antigen synthesized by human tumor cell lines in the presence of tunicamycin

1984 • 13 citations

Tumor scintigraphy with 131I anti CEA monoclonal antibodies and F(ab?)2 in colorectal cancer

1987 • 11 citations

Analysis of the specificity of CEA reactive monoclonal antibodies. Immunological support for the domain-model of CEA

1988 • 10 citations