Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

2001 • 727 citations

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

2001 • 713 citations

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

2000 • 704 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

Identification of a Novel Phosphorylation Site on Histone H3 Coupled with Mitotic Chromosome Condensation

1999 • 446 citations

DNA recombination: the replication connection

1999 • 411 citations

Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase

2001 • 361 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

A p34cdc2 survival checkpoint in cancer

2002 • 317 citations

Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

2003 • 312 citations

EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Δ mutants

2002 • 301 citations

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

2001 • 295 citations

Cooperative effects of genes controlling the G₂/M checkpoint

2000 • 269 citations

Dependence of Paclitaxel Sensitivity on a Functional Spindle Assembly Checkpoint

2004 • 260 citations

DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly Checkpoint

2002 • 216 citations

P53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines

2003 • 153 citations

Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function

2001 • 145 citations

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1999 • 124 citations

Association between Mitotic Spindle Checkpoint Impairment and Susceptibility to the Induction of Apoptosis by Anti-Microtubule Agents in Human Lung Cancers

2003 • 111 citations

Mad2 and BubR1 Function in a Single Checkpoint Pathway that Responds to a Loss of Tension

2002 • 99 citations

Prolonged arrest of mammalian cells at the G1/S boundary results in permanent S phase stasis

2002 • 79 citations

Overlapping Roles of the Spindle Assembly and DNA Damage Checkpoints in the Cell-Cycle Response to Altered Chromosomes in Saccharomyces cerevisiae

2002 • 76 citations

Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma

2002 • 76 citations

p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines

1996 • 66 citations

hBUB1 defects in leukemia and lymphoma cells

2002 • 62 citations

p53 Gene status in relation to ex vivo chemosensitivity of non-small cell lung cancer

2002 • 35 citations

Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility

2000 • 31 citations