Frequent impairment of the spindle assembly checkpoint in hepatocellular carcinoma

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Genetic instabilities in human cancers

1998 • 4,165 citations

Estimates of the worldwide incidence of 25 major cancers in 1990

1999 • 2,103 citations

Genetic instability in colorectal cancers

1997 • 1,989 citations

Catalog of chromosome aberrations in cancer

1985 • 1,522 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

2001 • 727 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

2001 • 553 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Chromosome Missegregation and Apoptosis in Mice Lacking the Mitotic Checkpoint Protein Mad2

2000 • 523 citations

SUBCUTANEOUS HEPARIN

1974 • 520 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

1996 • 422 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

Genetic instability of cancer cells is proportional to their degree of aneuploidy

1998 • 378 citations

Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation

2000 • 330 citations

Activation of the Protein Kinase p38 in the Spindle Assembly Checkpoint and Mitotic Arrest

1998 • 264 citations

A high prevalence of antibody to the hepatitis C virus in patients with hepatocellular carcinoma in Japan

1991 • 261 citations

CHRONIC LIVER DISEASE AND PRIMARY LIVER-CELL CANCER WITH HEPATITIS-ASSOCIATED (AUSTRALIA) ANTIGEN IN SERUM

1970 • 256 citations

Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes

1999 • 215 citations

Catalog of Chromosome Aberrations in Cancer

1996 • 204 citations

Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria - an epidemiological investigation

1984 • 182 citations

Aneuploidy correlated 100% with chemical transformation of Chinese hamster cells

1997 • 178 citations

p53 and pRb prevent rereplication in response to microtubule inhibitors by mediating a reversible G1 arrest.

1998 • 168 citations

A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein

1998 • 158 citations

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1999 • 124 citations

Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines

2000 • 95 citations

Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines

1999 • 67 citations

Persistent clonal areas and clonal expansion in Barrett's esophagus.

1992 • 63 citations

Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers

2001 • 62 citations

Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity

1998 • 57 citations

Epidermal growth factor and related molecules.

1989 • 57 citations

Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.

1998 • 56 citations

Search for in vivo somatic mutations in the mitotic checkpoint gene, hMAD1, in human lung cancers

1999 • 55 citations

Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1.

2000 • 52 citations

Altered dosage of the Saccharomyces cerevisiae spindle pole body duplication gene, NDC1 , leads to aneuploidy and polyploidy

1999 • 46 citations

Mitotic checkpoint genes hBUB1, hBUB1B, hBUB3 and TTK in human bladder cancer, screening for mutations and loss of heterozygosity

2001 • 43 citations

Investigation of Chromosomal Aberrations in Hepatocellular Carcinoma by Fluorescence In Situ Hybridization

1999 • 38 citations

THE ROLE OF DIETARY AFLATOXIN IN THE GENESIS OF HEPATOCELLULAR CANCER IN DEVELOPING COUNTRIES

1984 • 38 citations

Prospective flow cytometric DNA analysis of hepatocellular carcinoma specimens collected by ultrasound-guided fine needle aspiration

1994 • 24 citations

DNA ploidy of liver biopsies from patients with liver cirrhosis and hepatocellular carcinoma: a flow cytometric analysis

1999 • 24 citations

Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients

2000 • 21 citations