Reward and its control by dynorphin peptides

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.

1992 • 1,001 citations

Molecular cloning and functional expression of a mu opioid receptor from rat brain

1994 • 805 citations

Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.

1993 • 614 citations

Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine.

1985 • 594 citations

Neurochemical Basis of Acupuncture Analgesia

1982 • 586 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Motivational properties of kappa and mu opioid receptor agonists studied with place and taste preference conditioning

1985 • 516 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Genetic Selection for Voluntary Alcohol Consumption in the Albino Rat

1968 • 450 citations

Potentiation of Opiate Analgesia and Apparent Reversal of Morphine Tolerance by Proglumide

1984 • 269 citations

Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine

1985 • 201 citations

Possible regulatory role of dynorphin on morphine- and beta-endorphin-induced analgesia.

1981 • 169 citations

Antinociception and paralysis induced by intrathecal dynorphin A.

1985 • 164 citations

The AA and ANA rat lines, selected for differences in voluntary alcohol consumption

1989 • 153 citations

Differences between Alcohol‐Preferring (AA) and Alcohol‐Avoiding (ANA) Rats in the Prodynorphin and Proenkephalin Systems

1994 • 149 citations

Dynorphin: A possible modulatory peptide on morphine or β-endorphin analgesia in mouse

1981 • 142 citations

Cholecystokinin Antianalgesia: Safety Cues Abolish Morphine Analgesia

1992 • 138 citations

Differential interactions of cholecystokinin and FLFQPQRF-NH2 with μ and δ opioid antinociception in the rat spinal cord

1990 • 115 citations

Cholecystokinin antianalgesia: safety cues abolish morphine analgesia

1992 • 103 citations

Proglumide prevents and curtails acute tolerance to morphine in rats

1984 • 80 citations

Dynorphin A-(1-13) attenuates withdrawal in morphine-dependent rats: effect of route of administration

1988 • 71 citations

Suppression by dynorphin A and [des-Tyr1]dynorphin A peptides of the expression of opiate withdrawal and tolerance in morphine-dependent mice.

1993 • 67 citations

Increased neuropeptide-converting enzyme activities in cerebrospinal fluid of opiate-tolerant rats

1989 • 37 citations

Brain Stimulation and the Motivation of Behavior

1976 • 27 citations

Cholecystokinin (CCK)-like material and CCK mRNA levels in the rat brain and spinal cord after acute or repeated morphine treatment

1992 • 15 citations

Factor in human CSF with apparent morphine-antagonistic properties

1980 • 12 citations