Cancer Immunotherapy Targeting WT1 Protein

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia

1994 • 575 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis

1999 • 525 citations

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.

1994 • 509 citations

Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1

2000 • 420 citations

A clinical overview of WT1 gene mutations

1997 • 395 citations

Aberrant Overexpression of the Wilms Tumor Gene (WT1) in Human Leukemia

1997 • 375 citations

Expression of the Wilms' tumor gene (WT1) in human leukemias.

1992 • 354 citations

HLA class I-restricted lysis of leukemia cells by a CD8+ cytotoxic T-lymphocyte clone specific for WT1 peptide

2000 • 351 citations

High Levels of Wilms' Tumor Gene (wt1) mRNA in Acute Myeloid Leukemias Are Associated With a Worse Long-Term Outcome

1997 • 348 citations

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

1995 • 332 citations

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

1993 • 268 citations

Growth inhibition of human leukemic cells by WT1 (Wilms tumor gene) antisense oligodeoxynucleotides: implications for the involvement of WT1 in leukemogenesis

1996 • 268 citations

Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias.

1995 • 263 citations

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

1993 • 254 citations

Human cytotoxic T-lymphocyte responses specific for peptides of the wild-type Wilms' tumor gene ( WT1 ) product

2000 • 250 citations

Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development.

1991 • 243 citations

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

1999 • 243 citations

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

1992 • 226 citations

Expression of the Wilms' Tumor Gene WT1 in Solid Tumors and Its Involvement in Tumor Cell Growth

1999 • 216 citations

Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation.

2001 • 212 citations

The Wilms tumour gene WT1 is expressed in murine mesoderm–derived tissues and mutated in a human mesothelioma

1993 • 211 citations

Cancer Immunotherapy Targeting Wilms’ Tumor Gene WT1 Product

2000 • 211 citations

Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

1995 • 206 citations

Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers

2002 • 205 citations

High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients.

2002 • 202 citations

Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma.

1995 • 197 citations

Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer

1997 • 193 citations

The Wilms’ tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes

1999 • 188 citations

Wilms' Tumor Gene (WT1) Competes With Differentiation-Inducing Signal in Hematopoietic Progenitor Cells

1998 • 178 citations

Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms' tumor locus.

1993 • 171 citations

WT1 -Mediated Growth Suppression of Wilms Tumor Cells Expressing a WT1 Splicing Variant

1993 • 162 citations

The role of WT1 in Wilms tumorigenesis

1993 • 156 citations

Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells.

1993 • 152 citations

Immunity to WT1 in the animal model and in patients with acute myeloid leukemia

2000 • 144 citations

The Wilms’ Tumor Suppressor Gene (wt1) Product Regulates Dax-1 Gene Expression during Gonadal Differentiation

1999 • 141 citations

Wilms’ Tumor GeneWT1: Its Oncogenic Function and Clinical Application

2001 • 130 citations

Humoral immune responses against Wilms tumor gene WT1product in patients with hematopoietic malignancies

2002 • 124 citations

The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells.

1994 • 115 citations

Constitutive expression of the Wilms’ tumor gene WT1 inhibits the differentiation of myeloid progenitor cells but promotes their proliferation in response to granulocyte-colony stimulating factor (G-CSF)

1999 • 99 citations

Repression of the retinoic acid receptor-alpha gene by the Wilms' tumor suppressor gene product, wt1.

1995 • 90 citations

Wilms' tumor suppressor gene expression in rat and human mesothelioma.

1994 • 89 citations

WT1 as a Novel Target Antigen for Cancer Immunotherapy

2002 • 75 citations

Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination.

2000 • 75 citations

Expression of the WT1 Wilms' tumor gene by normal and malignant human melanocytes

1994 • 74 citations

Analysis of the 11p13 Wilms' Tumor Suppressor Gene (WTI) in Ovarian Tumors

1993 • 74 citations

Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma

1998 • 71 citations

Multiple roles for the Wilms' tumor suppressor, WT1.

1999 • 61 citations

Detection by monoclonal antibodies of the Wilms' tumor (WT1) nuclear protein in patients with acute leukemia

1997 • 61 citations

Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens

2000 • 60 citations

Induction of Rb-associated Protein (RbAp46) by Wilms' Tumor Suppressor WT1 Mediates Growth Inhibition

1998 • 60 citations

Identification of a novel WT1‐derived peptide which induces human leucocyte antigen‐A24‐restricted anti‐leukaemia cytotoxic T lymphocytes

2002 • 60 citations

WT1-specific serum antibodies in patients with leukemia.

2001 • 57 citations

Isolation, Characterization, and Expression of the Murine Wilms’ Tumor Gene (WT1) During Kidney Development

1991 • 57 citations

HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria

2002 • 53 citations

Repression of the c-myb Gene by WT1 Protein in T and B Cell Lines

1995 • 50 citations

Expression of the wilms' tumor gene WT1 in human malignant mesothelioma cell lines and relationship to platelet‐derived growth factor A and insulin‐like growth factor 2 expression

1995 • 47 citations

Molecular mechanisms possibly affecting WT1 function in human ovarian tumors

1994 • 43 citations

WT1 contributes to leukemogenesis: Expression patterns in 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia

1997 • 33 citations

Ornithine Decarboxylase Is a Transcriptional Target of Tumor Suppressor WT1

1999 • 32 citations

Homozygous intragenic deletion in the WT1 gene in a sporadic Wilms' tumour associated with high levels of expression of a truncated transcript

1995 • 23 citations

Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1.

1999 • 21 citations

Immunotherapy for Leukemia Targeting the Wilms' Tumor Gene

2001 • 6 citations

Deleted Work

1955 • 0 citations