Extravascular transport in normal and tumor tissues

The dispersion of matter in turbulent flow through a pipe

1954 • 1,781 citations

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

1919 • 1,388 citations

Chemistry and biology of pteridines

1956 • 1,263 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

Passage of Molecules Through Capillary Walls

1953 • 942 citations

METHODS IN MEDICAL RESEARCH

1967 • 890 citations

SELF-REGULATION OF GROWTH IN THREE DIMENSIONS

1973 • 811 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles

1959 • 717 citations

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

1978 • 707 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas<xref ref-type="fn" rid="FN2">2</xref>

1971 • 580 citations

The clinical pharmacology of methotrexate.new applications of an old drug

1978 • 561 citations

Models for the Growth of a Solid Tumor by Diffusion

1972 • 560 citations

Physiologically Based Pharmacokinetic Modeling: Principles and Applications

1983 • 560 citations

Ionic Mobility in Muscle Cells

1969 • 510 citations

On the transport of compact particles through solutions of chain-polymers

1973 • 489 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Diffusion and convection in normal and neoplastic tissues.

1974 • 395 citations

A fiber matrix model of capillary permeability

1980 • 392 citations

Animal scale-up

1973 • 389 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Restricted Transport in Small Pores

1974 • 383 citations

Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment

1968 • 383 citations

Solution properties of branched dextrans

1958 • 315 citations

Multiple pathways of capillary permeability.

1977 • 313 citations

Organ perfusion and preservation

1968 • 312 citations

Differential response of normal and tumor microcirculation to hyperthermia.

1984 • 308 citations

Hyperthermia in Cancer Therapy.

1983 • 299 citations

Studies of the enzymatic deamination of cytosine arabinoside—I

1965 • 296 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

Transport of large molecules from plasma to interstitial fluid and lymph in dogs

1970 • 258 citations

Tumor Behavior in Isolated Perfused Organs

1966 • 247 citations

Structural aspects of the permeability of the microvascular endothelium.

1979 • 241 citations

THE INTERSTITIAL FLUID OF SOLID TUMORS.

1964 • 240 citations

Vascular structures in brain tumors

1975 • 239 citations

Increase in microvascular permeability induced by enzymatically generated free radicals

1981 • 237 citations

New Approaches to Cancer Chemotherapy with Methotrexate

1975 • 228 citations

Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia

1984 • 226 citations

Observations on changes in blood vascular endothelium in the living animal

1935 • 221 citations

Growth and metastasis of tumor in organ culture

1963 • 220 citations

Cell distribution in capillary networks

1980 • 219 citations

Methods for quantifying the transport of drugs across brain barrier systems

1981 • 214 citations

Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model

1974 • 214 citations

Thiopental Pharmacokinetics

1968 • 207 citations

Methotrexate: clinical pharmacology, current status and therapeutic guidelines

1977 • 203 citations

A new method for the microscopic study of living growing tissues by the introduction of a transparent chamber in the rabbit's ear

1924 • 196 citations

Rate of growth of solid tumours as a problem of diffusion.

1966 • 195 citations

A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat.

1977 • 185 citations

Nonlinear pharmacokinetic models for 5-fluorouracil in man: Intravenous and intraperitoneal routes

1980 • 181 citations

Facilitated transport via carrier‐mediated diffusion in membranes: Part I. Mechanistic aspects, experimental systems and characteristic regimes

1974 • 176 citations

Polygammaglutamyl metabolites of methotrexate

1973 • 171 citations

Permeability of Different Experimental Brain Tumor Models to Horseradish Peroxidase

1982 • 167 citations

A Concurrent Flow Model for Extraction during Transcapillary Passage

1974 • 167 citations

Increase in microvascular permeability induced by enzymatically generated free radicals

1981 • 167 citations

Drag coefficients for the movement of rigid spheres through liquid-filled cylindrical pores

1975 • 155 citations

Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells

1961 • 152 citations

Response of cells to hyperthermia under acute and chronic hypoxic conditions.

1979 • 151 citations

Transport and Binding of Methotrexate In Vivo

1973 • 147 citations

Energy metabolism, body size, and problems of scaling.

1970 • 146 citations

Interstitial diffusion of macromolecules in the rat mesentery

1979 • 144 citations

Physiologically Based Pharmacokinetic Model for β-Lactam Antibiotics I: Tissue Distribution and Elimanation Rates

1983 • 143 citations

Chemotherapy of cancer dissemination and metastasis

1973 • 136 citations

Transport Energetics of the Folic Acid Analogue, Methotrexate, in L1210 Leukemia Cells

1969 • 133 citations

On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.

1968 • 129 citations

Vascular-extravascular exchange of I¹³¹ plasma proteins in the rat

1959 • 123 citations

A mathematical analysis of capillary-tissue fluid exchange1

1974 • 122 citations

EFFECT OF HYPERTHERMIA ON VASCULAR FUNCTION IN NORMAL AND NEOPLASTIC TISSUES*

1980 • 121 citations

Oxygen Diffusion Distance and Development of Necrosis in Multicell Spheroids

1979 • 121 citations

Prediction of the disposition ofβ-lactam antibiotics in humans from pharmacokinetic parameters in animals

1984 • 119 citations

Leucocyte migration from small blood vessels stimulated with ultraviolet light: An electron‐microscope study

1961 • 119 citations

General observations on the ingrowth of new blood vessels into standardized chambers in the rabbit's ear, and the subsequent changes in the newly grown vessels over a period of months

1931 • 117 citations

Observations on the growth of blood vessels as seen in the transparent chamber introduced into the rabbit's ear

1928 • 117 citations

Observations on living arterio‐venous anastomoses as seen in transparent chambers introduced into the rabbit's ear

1934 • 116 citations

The transparent chamber of the rabbit's ear, giving a complete description of improved technic of construction and introduction, and general account of growth and behavior of living cells and tissues as seen with the microscope

1928 • 113 citations

Recent modifications in the method of studying living cells and tissues in transparent chambers inserted in the rabbit's ear

1930 • 109 citations

Lidocaine disposition kinetics in monkey and man; II. Effects of hemorrhage and sympathomimetic drug administration

1974 • 108 citations

Studies of the metabolism of methotrexate by intestinal flora—I

1972 • 108 citations

Pharmacokinetics of 1-β-d-arabinofuranosylcytosine (Ara-C) deamination in several species

1973 • 108 citations

Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

1965 • 107 citations

Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model

1983 • 106 citations

Extracellular Compartments of Solid Tumors

1975 • 105 citations

Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.

1968 • 101 citations

Development of the vascular system in the hamster malignant neurilemmoma

1973 • 101 citations

Studies on the Exchange of Fluids Between Host and Tumor. I. A Method for Growing “Tissue-Isolated” Tumors in Laboratory Animals<xref ref-type="fn" rid="FN1">2</xref>

1961 • 100 citations

Dynamics of neovascularization in normal tissue

1981 • 99 citations

Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors.

1984 • 98 citations

The glucose distribution in 9l rat brain multicell tumor spheroids and its effect on cell necrosis

1982 • 96 citations

Hypoxic Cells in anin VitroTumour Model

1973 • 96 citations

In vitro-in vivo correlation of drug metabolism-deamination of 1-β-d-arabinofuranosylcytosine

1972 • 96 citations

Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice.

1984 • 95 citations

Continuous Noninvasive Monitoring of pH and Temperature in Rat Walker 256 Carcinoma During Normoglycemia and Hyperglycemia23

1984 • 94 citations

Concentration profiles in and around capillaries

1960 • 93 citations

Enhanced lymphatic delivery of mitomycin C conjugated with dextran.

1984 • 92 citations

Macromolecular transport in the cat mesentery

1975 • 91 citations

A model for the growth of a solid tumor with non-uniform oxygen consumption

1977 • 87 citations

The respiration of ascites tumour cells at low oxygen concentrations

1962 • 87 citations

K+‐Permeability of the Blood‐Brain Barrier, Investigated by Aid of a K+‐Sensitive Microelectrode

1977 • 87 citations

Vasculature of Neural Neoplasms.

1976 • 86 citations

Transport pathways for fluid and large molecules in microvascular endothelium of the dog's paw

1977 • 86 citations

The influence of oxygen on viability and proliferation in cellular spheroids

1979 • 85 citations

The reversal of methotrexate toxicity by thymidine with maintenance of antitumour effects

1975 • 84 citations

Characteristics of the Vincristine-induced Augmentation of Methotrexate Uptake in Ehrlich Ascites Tumor Cells

1973 • 82 citations

Monoclonal Antibodies in the Lymphatics: Selective Delivery to Lymph Node Metastases of a Solid Tumor

1983 • 82 citations

Comparative physiologically based pharmacokinetics of hexobarbital, phenobarbital, and thiopental in the rat

1982 • 81 citations

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1975 • 81 citations

Multiple model approach to uptake and distribution of halothane: The use of an analog computer

1972 • 79 citations

A model system for the study of heteroexchange diffusion: Methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells

1971 • 78 citations

Quantitative study of vascularity in Walker carcinoma 256.

1971 • 76 citations

The ultrastructure and permeability characteristics of the blood vessels of a transplantable rat sarcoma

1972 • 75 citations

Preliminary pharmacokinetic model for adriamycin (NSC-123127).

1975 • 74 citations

The mechanism of action of methotrexate. I. Interaction with a low-affinity intracellular site required for maximum inhibition of deoxyribonucleic acid synthesis in L-cell mouse fibroblasts.

1974 • 74 citations

Permeability of lung capillaries to macromolecules in foetal and new‐born lambs and sheep

1969 • 72 citations

Extracellular water measurements: organ tracer kinetics of bromide and sucrose in rats and man

1978 • 71 citations

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.

1970 • 70 citations

ENDOTHELIAL PERMEABILITY: PATHWAYS AND MODULATIONS*

1982 • 69 citations

Observations on polymorphonuclear leukocytes in the living animal

1936 • 69 citations

Pharmacokinetic study of cis-dichlorodiammineplatinum(II) (DDP) in the beagle dog: thermodynamic and kinetic behavior of DDP in a biologic millieu.

1979 • 68 citations

Dextrans as test molecules in studies of the functional ultrastructure of biological membranes

1972 • 68 citations

Improved microcirculation in irradiated tumours

1971 • 66 citations

On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitro

1965 • 66 citations

Physiologically Based Pharmacokinetic Model for Digoxin Distribution and Elimination in the Rat

1977 • 66 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

1976 • 64 citations

Observations on living mammalian lymphatic capillaries–their relation to the blood vessels

1937 • 63 citations

Physiologically Based Pharmacokinetic Model for Digoxin Disposition in Dogs and Its Preliminary Application to Humans

1977 • 63 citations

Alteration of methotrexate uptake in human leukemia cells by other agents.

1975 • 62 citations

Plasma pharmacokinetics and interstitial diffusion of macromolecules in a capillary bed

1984 • 62 citations

Inhibition of the membrane transport of folates by anions retained in uremia.

1975 • 61 citations

Oxygen Transport to Tissue — II

1976 • 61 citations

Influence of histamine and some other substances on blood-lymph transport of plasma protein and dextran in the dog paw

1974 • 60 citations

Electrical resistance of muscle capillary endothelium

1983 • 59 citations

Caliber changes in minute blood‐vessels observed in the living mammal

1943 • 59 citations

Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas.

1983 • 58 citations

The microcirculatory society Eugene M. Landis award lecture

1978 • 57 citations

Diffusional model for transport rate studies across membranes

1967 • 57 citations

The permeability of single capillaries to potassium ions.

1978 • 56 citations

High dose methotrexate therapy of solid tumors: observations relating to clinical toxicity

1976 • 55 citations

The ultrastructure of the microcirculation at the advancing edge of Walker 256 carcinoma

1970 • 55 citations

Endothelial fenestrations and other vascular alterations in primary melanoma of the central nervous system

1974 • 55 citations

A physiological pharmacokinetic model for morphine disposition in the pregnant rat

1983 • 54 citations

Model for the growth of a solid in vitro tumor.

1975 • 54 citations

Exchangeability of tissue potassium in skeletal muscle

1959 • 54 citations

Identification of the small pore in muscle capillaries.

1979 • 54 citations

Permeability of the blood-brain barrier

1985 • 54 citations

Membrane transport of methotrexate in human lymphoblastoid cells.

1978 • 52 citations

Permeability of single capillaries to intermediate-sized colored solutes

1983 • 51 citations

Dose-dependent metabolism of methotrexate in man and rhesus monkeys.

1977 • 51 citations

Radiation survival of cells from spheroids grown in different oxygen concentrations.

1979 • 50 citations

Studies of the enzymatic deamination of cytosine arabinoside—II

1967 • 50 citations

Enteric transport of chlordecone (Kepone®) in the rat

1981 • 50 citations

Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.

1972 • 50 citations

The Analysis of Convection and Diffusion in Capillary Beds

1974 • 50 citations

Hearing, Single-Unit Analysis, and Vocalizations in Songbirds

1969 • 47 citations

Assay for 4-amino folic acid analogues by inhibition of folic acid reductase.

1962 • 47 citations

THE MECHANISM OF CAPILLARY CONTRACTION

1940 • 47 citations

Pharmacokinetics of 2-butanol and its metabolites in the rat

1981 • 47 citations

Generalized solution to linear, two-compartment, open model for drug distribution

1970 • 46 citations

Microcirculatory flow changes during tissue growth

1983 • 46 citations

Observations on the circulating blood cells, adventitial (Rouget) and muscle cells, endothelium, and macrophages in the transparent chamber of the rabbit's ear

1931 • 44 citations

In Vivo Utilization of Oxygen and Glucose by Neoplastic Tissue

1976 • 44 citations

Controlled release of tetracycline—III: A physiological pharmacokinetic model of the pregnant rat

1980 • 44 citations

Studies on drug resistance—I

1969 • 44 citations

Membrane transport of methotrexate (NSC 740) and other folate compounds: relevance to rescue protocols

1975 • 43 citations

High-speed photography

1983 • 43 citations

Kinetics of uptake, distribution, and excretion of zinc in rats

1981 • 43 citations

Pharmacokinetic modeling of the dogfish shark (Squalus acanthias): Distribution and urinary and biliary excretion of phenol red and its glucuronide

1976 • 43 citations

A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat

1984 • 43 citations

THE EXTRACELLULAR SPACE IN BRAIN TUMOURS

1970 • 43 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits.

1987 • 42 citations

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

1976 • 42 citations

High-dose methotrexate-citrovorum factor rescue in the management of brain tumors.

1977 • 41 citations

In Vivo Techniques in Histology

1967 • 40 citations

Effect of irradiation on tumor microvascular permeability to macromolecules

1972 • 40 citations

Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues.

1985 • 39 citations

Measurements of Blood Flow Velocity in the Microcirculation

1975 • 39 citations

MATHEMATICAL SIMULATION IN CHEMOTHERAPY*

1971 • 39 citations

The mechanism of folate transport in rabbit reticulocytes

1972 • 38 citations

Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells.

1974 • 38 citations

A model for the kinetics of distribution of actinomycin-D in the beagle dog.

1977 • 38 citations

A method of studying the effects of chemicals upon living cells and tissues in the moat chamber, a transparent chamber inserted in the rabbit's ear

1932 • 37 citations

Amethopterin transport in Ehrlich ascites carcinoma and L1210 cells.

1967 • 37 citations

Radiation Survival of Cells from Spheroids Grown in Different Oxygen Concentrations

1979 • 37 citations

A Nonlinear Model for the Uptake and Distribution of Halothane in Man

1970 • 37 citations

Drug resistance and selectivity. Biochemical and cellular basis

1975 • 37 citations

Interaction between the Circulatory Effects and the Uptake and Distribution of Halothane

1972 • 37 citations

Blood flow limitations in interpreting michaelis constants for ethanol oxidation in vivo

1973 • 37 citations

Effects of Indomethacin on the Transcapillary Leakage of Macromolecules and the Efflux of Prostaglandins in the Paw Lymph Following Experimental Scalding Injury

1973 • 35 citations

Distribution of Anticancer Agents in Spontaneous Animal Tumors. I. Regional Blood Flow and Methotrexate Distribution in Canine Lymphosarcoma2

1974 • 35 citations

Exchangeable intracellular methotrexate levels in the presence and absence of vincristine at extracellular drug concentrations relevant to those achieved in high-dose methotrexate-folinic acid "rescue" protocols.

1976 • 35 citations

Effects of oncotic gradients and enzymes on negative pressures in implanted capsules

1970 • 35 citations

Concentration of Trypsin Inhibitors of Different Molecular Size and of Albumin and Haptoglobin in Blood and in Lymph of Various Organs in the Dog

1970 • 35 citations

Pharmacokinetics of methotrexate in solid tumors

1979 • 35 citations

Microphotoelectric plethysmography using a rabbit ear chamber

1965 • 34 citations

Lithium pharmacokinetics: Single-dose experiments and analysis using a physiological model

1980 • 34 citations

Uptake of radiolabeled alpha-fetoprotein by mouse mammary carcinomas and its usefulness in tumor scintigraphy.

1984 • 33 citations

Relative biochemical aspects of low and high doses of methotrexate in mice.

1977 • 33 citations

Pharmacokinetic Model for Simultaneous Determination of Drug Levels in Organs and Tissues

1976 • 33 citations

Effects of selected cancer chemotherapeutic drugs on the survival times of mice with L-1210 leukemia: relative responses of antimetabolite resistant strains.

1962 • 33 citations

Active transport of aminopterin in Yoshida sarcoma cells

1967 • 32 citations

Prediction of the distribution of methotrexate in the sting rays Dasyatidae sabina and sayi by use of a model developed in mice

1972 • 32 citations

Tissue distribution kinetics of tetraethylammonium ion in the rat

1980 • 32 citations

The mechanism of action of methotrexate. II. Augmentation by vincristine of inhibition of deoxyribonucleic aic synthesis by methotrexate in Ehrlich ascites tumor cells.

1974 • 31 citations

Studies on the capillary permeability of experimental liver metastases.

1978 • 31 citations

Pharmacokinetics of 3,3',5,5'-tetrachlorobiphenyl in the male rat.

1977 • 31 citations

A titanium rabbit ear chamber: Assembly, insertion and results

1970 • 30 citations

Pore and fiber-matrix models for diffusive transport in normal and neoplastic tissues

1984 • 29 citations

Microscopic Studies in Living Mammals with Transparent Chamber Methods

1954 • 29 citations

A modification of a Sandison‐Clark chamber for observation of transparent tissue in the rabbit's ear

1939 • 29 citations

Computer simulation of sulfobromophthalein kinetics in the rat using flow-limited models with extrapolation to man

1975 • 29 citations

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

1976 • 29 citations

Mass Transport in Tumors: Characterization and Applications to Chemotherapy

1980 • 28 citations

The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma

1975 • 28 citations

An improved tantalum chamber for prolonged microscopic study of living cells in mammals

1950 • 28 citations

Tumor and tissue distribution of a methotrexate-anti-EL4 immunoglobulin conjugate in EL4 lymphoma-bearing mice.

1984 • 28 citations

Analysis of coupled intra- and extraluminal flows for single and multiple capillaries

1982 • 28 citations

Folate antagonists as chemotherapeutic agents

1971 • 27 citations

Rate of Intracellular Diffusion as Measured in Barnacle Muscle

1969 • 27 citations

Effects of Anesthetic-depressed Ventilation and Cardiac Output on Anesthetic Uptake: A Computer Nonlinear Simulation

1973 • 27 citations

Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.

1976 • 27 citations

Estimate of capillary permeability coefficients of canine heart to sodium and glucose

1978 • 27 citations

Modifications of the Rabbit Ear Chamber Technique

1949 • 27 citations

High-dose methotrexate with citrovorum factor in osteogenic sarcoma--progress report II.

1977 • 27 citations

Measurement of growth rate of laser-induced intravascular platelet aggregation and the influence of blood flow velocity

1976 • 26 citations

Effects of allopurinol on the therapeutic efficacy of methotrexate.

1975 • 26 citations

Diffusion with irreversible chemical reaction in heterogeneous media: Application to oxygen transport in respiring tissue

1977 • 26 citations

Permeability of single muscle capillaries to potassium ions

1982 • 26 citations

A physiological model for the pharmacokinetics of methylene chloride in B6C3F1 mice following i.v. administrations

1984 • 25 citations

The construction of a pharmacokinetic model for the disposition of polychlorinated biphenyls in the rat

1977 • 25 citations

Permeability of intestinal capillaries to small molecules

1981 • 25 citations

A modified rabbit's ear chamber high‐power high‐resolution studies in regenerated and preformed tissues

1963 • 25 citations

Mass transfer between capillary blood and tissues

1974 • 25 citations

Comparison of folate reductases of sarcoma 180 cells, sensitive and resistant to amethopterin.

1967 • 24 citations

Pharmacokinetic Model for Salicylate in Cerebrospinal Fluid, Blood, Organs, and Tissues

1978 • 24 citations

A new blood-flow pharmacokinetic model for ethanol

1981 • 23 citations

Pharmacokinetics of Mercaptopurine

1977 • 22 citations

Chamber techniques to study the microvasculature

1973 • 22 citations

Studies on Heart Lymph

1964 • 22 citations

Physiologic model for the pharmacokinetics of 2′deoxycoformycin in normal and leukemic mice

1981 • 21 citations

The relationship among transport, intracellular binding, and inhibition of RNA synthesis by actinomycin D in Ehrlich ascites tumor cells in vitro.

1975 • 21 citations

Defective transport of aminopterin in relation to development of resistance in Yoshida sarcoma cells

1967 • 21 citations

Permeability of Ehrlich ascites cells to folic acid, aminopterin, and amethopterin.

1966 • 20 citations

Radiation Damage to the Microvasculature in the Rabbit Ear Chamber: An Electron Microscope Study

1977 • 20 citations

Physiological Perfusion Model for Cephalosporin Antibiotics I: Model Selection Based on Blood Drug Concentrations

1978 • 19 citations

The transparent chamber adapted for cell culture and permitting access to the contained living tissue

1934 • 19 citations

The effect of vincristine on methotrexate uptake and inhibition of DNA synthesis by human lymphoblastoid cells.

1977 • 19 citations

The Independent Control of the Capillary Circulation in a Mammal¹

1936 • 19 citations

Fiber Optic Microfluorimetry for Acute and Chronic In-Vivo Animal Studies

1980 • 19 citations

An improved method for the production of tubercles in a chamber in the rabbit's ear.

1954 • 19 citations

Drug elimination interactions: Analysis using a mathematical model

1979 • 18 citations

The penetration of cytotoxins into malignant tumours

1968 • 18 citations

A radioimmunoassay for methotrexate and its comparison with spectrofluorimetric procedures.

1976 • 18 citations

Further observations on the microscopic appearance and behavior of living thyroid follicles in the rabbit

1939 • 17 citations

Transient convective mass transfer in Krogh tissue cylinders

1978 • 17 citations

STUDIES IN THE FUNCTION OF NUTRITIVE CAPPILARIES IN THE CONNECTIVE TISSUE IN RABBIT'S EAR CHAMBER.

1963 • 17 citations

Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture.

1980 • 17 citations

Nonlinear Pharmacokinetic Model of Intravenous Anesthesia

1976 • 16 citations

Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.

1984 • 16 citations

The role of glucose in the growth of 9l multicell tumor spheroids

1982 • 16 citations

Primary Mammary Tumors Connected to the Host by a Single Artery and Vein

1973 • 16 citations

In vio mass transfer of chloride during exchange hemodialysis.

1970 • 15 citations

Pharmacology of a new triazine antifolate in mice, rats, dogs, and monkeys.

1975 • 15 citations

Pharmacokinetics of methotrexate in leukemia cells: Effect of dose and mode of injection

1978 • 15 citations

Monitoring transport in the rabbit ear chamber

1982 • 15 citations

Two-compartment model for plasma pharmacokinetics in individual blood vessels

1984 • 14 citations

Role of the cell membrane in the uptake of 3H-actinomycin D by mammalian cells in vitro.

1975 • 14 citations

Construction and use of a miniaturized rabbit ear chamber

1970 • 14 citations

In Vivo Techniques in Histology

1969 • 13 citations

Mathematical Model for Cyclocytidine Pharmacokinetics

1977 • 13 citations

A STUDY OF ALLOGRAFT KIDNEY REJECTION OCCURRING SIMULTANEOUSLY IN WHOLE ORGAN AND EAR CHAMBER GRAFTS IN THE RABBIT

1973 • 12 citations

Studies on the structure and function of arterio-venous anastomoses in the rabbit's ear

1954 • 12 citations

THE RESPONSE OF THE MACROPHAGE TO ANTIGENIC AZOPROTEIN, STUDIED IN THE RABBIT EAR CHAMBER PREPARATION

1952 • 11 citations

Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey.

1979 • 11 citations

The Effect of Trimethoprim on Cellular Transport of Methotrexate and its Cytotoxicity to Human Lymphoblastoid Cells in Vitro

1976 • 10 citations

A comparison of 4-amino-4-deoxy-N10-methylpteroic acid and methotrexate transport by mouse leukemia cells.

1969 • 10 citations

A fluorometric determination of adriamycin and its metabolites in biological tissues.

1973 • 10 citations

Pharmacokinetics of 5-fluorouracil following different routes of intrahepatic administration in the canine model.

1984 • 9 citations

REPRESENTATION OF CERTAIN MAMMILLARY N-POOL SYSTEMS BY TWO-POOL MODELS.

1964 • 9 citations

Pharmacokinetic Model for Procaine in Humans during and following Intravenous Infusion

1979 • 9 citations

Disposition of cytosine arabinoside (NSC-63878) and its metabolites: a pharmacokinetic simulation.

1975 • 9 citations

Cytokinetic aspects of clinical drug resistance.

1975 • 9 citations

Cutaneous microcirculatory responses to insulin administration in the fasted normal rabbit, with special regard to peripheral circulating leukocytes

1975 • 8 citations

Translocation of DNA from the vascular into the nuclear compartment of solid mammary tumors.

1971 • 8 citations

High-dose methotrexate therapy with citrovorum factor: a pharmacologic perspective in murine tumor models.

1977 • 7 citations

Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells

1982 • 7 citations

Supporting Role of Vasodilators in Inducing Regressions of the Ehrlich Solid Tumor.

1967 • 7 citations

Transport of methotrexate and other folate compounds: Components, mechanism and regulation by cyclic nucleotides

1977 • 6 citations

A simplified rabbit ear chamber.

1959 • 6 citations

Device for constant Sc infusion of methotrexate: plasma results in mice.

1976 • 6 citations

RHYTHMIC CIRCULATORY CHANGES IN THE PERIPHERAL VASCULATURE*

1962 • 6 citations

Tolerance of long-term methotrexate infusions by mice

1976 • 5 citations

On Transplantation of Tumors

1978 • 5 citations

Preliminary model for streptozocin metabolism in mice

1980 • 5 citations

The permeability to human serum albumin (HSA) and polyvinylpyrrolidone (PVP) of skeletal muscle (rat cremaster) blood vessel walls.

1969 • 5 citations

A tantalum chamber for the microscopic study of living cells and tissues transplanted to the rabbit's ear

1948 • 5 citations

Analysis of transcapillary exchange and intraluminal transport in the microocclusion of single capillaries

1983 • 4 citations

The Clinical Pharmacology of Cytosine Arabinoside

1983 • 4 citations

In vivo measurement of microvasculature: A method for repeated and reproducible quantitation during long-term experiments

1979 • 4 citations

Cutaneous microcirculatory responses to insulin administration in the fasted and hexamethonium-treated rabbit, with special regard to peripheral circulating leukocytes

1975 • 4 citations

Comparisons of vascular permeability of tumors and liver host tissue.

1977 • 4 citations

In Vivo Pharmacokinetics of Triazinate in L-1210 and W-256 Cells

1982 • 3 citations

Kinetics of methotrexate uptake by human tumor cells from routine pathological samples.

1978 • 3 citations

SOME DEVELOPMENTS IN RABBIT EAR CHAMBER TECHNIQUES

1951 • 3 citations

Quantitative studies of the rate of removal of urea by living blood capillaries from extravascular solutions in transparent moat chambers introduced into the rabbit's ear

1937 • 3 citations

An electrode-containing rabbit ear chamber for microvascular measurements

1970 • 2 citations

Deleted Work

1955 • 0 citations