Physiologic model for the pharmacokinetics of 2′deoxycoformycin in normal and leukemic mice

Tight-binding inhibitors—I

1975 • 497 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Tight-binding inhibitors—IV. Inhibition of adenosine deaminases by various inhibitors

1977 • 376 citations

A novel adenosine and ara‐a deaminase inhibitor, (R)‐3‐(2‐deoxy‐β‐D‐erythro‐pentofuranosyl)‐3,6,7,8‐tetrahydroimidazo[4,5 ‐d] [1,3]diazepin‐8‐ol

1974 • 226 citations

A review of the applications of physiologically based pharmacokinetic modeling

1979 • 190 citations

A study of the tissue distribution of adenosine deaminase in six mammal species

1965 • 144 citations

Enhancement of the antitumor activity of arabinofuranosyladenine of 2'-deoxycoformycin.

1976 • 125 citations

Pharmacokinetics of 1-β-d-arabinofuranosylcytosine (Ara-C) deamination in several species

1973 • 108 citations

The clinical pharmacology of the adenosine deaminase inhibitor 2?-deoxycoformycin

1980 • 88 citations

Enhancement of the Biological Activity of Adenosine Analogs by the Adenosine Deaminase Inhibitor 2’-Deoxycoformycin

1977 • 66 citations

Physiological pharmacokinetics: An in vivo approach to membrane transport

1980 • 59 citations

In vivo toxicity to lymphoid tissue by 2?-Deoxycoformycin

1978 • 42 citations

Distribution of Anticancer Agents in Spontaneous Animal Tumors. I. Regional Blood Flow and Methotrexate Distribution in Canine Lymphosarcoma2

1974 • 35 citations

INHIBITION OF ADENOSINE DEAMINASE BY CO‐VIDARABINE AND ITS EFFECT ON THE METABOLIC DISPOSITION OF ADENINE ARABINOSIDE (VIDARABINE)

1977 • 34 citations

Enzyme inhibition titration assay for 2′-deoxycoformycin and its application to the study of the relationship between drug concentration and tissue adenosine deaminase in dogs and rats

1979 • 33 citations

The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma

1975 • 28 citations

Therapeutic effects of 9-beta-D-arabinofuranosyladenine and 2'-deoxycoformycin combinations on intracerebral leukemia.

1977 • 28 citations

Effects of 2'-deoxycoformycin infusion on mouse adenosine deaminase.

1979 • 25 citations

Use of microbiologic and enzymatic assays in studies on the disposition of 2'-deoxycomformycin in the mouse.

1978 • 22 citations

The metabolism of 2'-deoxycoformycin by L1210 cells invitro

1979 • 16 citations

Pharmacokinetic model for 2-amino-1,3,4-thiadiazole in mouse, dog, and monkey.

1979 • 11 citations

Pharmokinetics of 2'-deoxycoformycin in normal and L1210 leukemic mice.

1979 • 10 citations

Preliminary model for streptozocin metabolism in mice

1980 • 5 citations