A physiological pharmacokinetic model for morphine disposition in the pregnant rat

Textbook of Medical Physiology

1966 • 10,259 citations

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Textbook of Medical Physiology

1957 • 418 citations

The Relationship of Pharmacokinetics to Pharmacological Activity

1976 • 231 citations

Morphine metabolism in man

1974 • 228 citations

A review of the applications of physiologically based pharmacokinetic modeling

1979 • 190 citations

Pharmacologic basis for the increased sensitivity of the newborn rat to morphine.

1963 • 146 citations

Cardiac output and organ blood flow in warm- and cold-acclimated rats exposed to cold

1968 • 130 citations

Morphine kinetics in children

1979 • 129 citations

Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat

1978 • 98 citations

Pharmacokinetic concepts ? Drug binding, apparent volume of distribution and clearance

1981 • 90 citations

Determination of opiates in biological samples by glass capillary gas chromatography with electron-capture detection

1981 • 65 citations

Perinatal pharmacology and therapeutics

1978 • 58 citations

Metabolism of drugs in rat liver during the perinatal period

1971 • 47 citations

Pharmacokinetics of morphine in plasma and discrete areas of the rat brain

1975 • 46 citations

Pharmacokinetic Model for Simultaneous Determination of Drug Levels in Organs and Tissues

1976 • 33 citations

COMPARATIVE DISTRIBUTION OF TRITIUM-LABELED DIHYDROMORPHINE BETWEEN MATERNAL AND FETAL RATS.

1965 • 33 citations

Circulatory Changes during Pregnancy in Spontaneously and Renal Hypertensive Rats

1979 • 28 citations

Perinatal Pharmacology and Therapeutics

1976 • 26 citations

Binding of drugs to human muscle

1978 • 21 citations

DISTRIBUTION OF TRITIUM‐LABELLED ETORPHINE (M99) AND DIHYDROMORPHINE IN PREGNANT RATS AT TERM

1967 • 19 citations

Maternal and fetal distribution of H3-dihydromorphine in the tolerant and nontolerant rat.

1970 • 13 citations

Morphine in Fetuses after Maternal Injection: Increasing Concentration with Advancing Gestational Age

1979 • 12 citations

Metabolism of Morphine in the Perfused Rat Liver

1976 • 9 citations

Interrelations of fetal circulation and the placental transfer of drugs.

1972 • 5 citations

Mathematical prediction of drug distributionin vivo: Studies with doxantrazole in rats

1978 • 3 citations