Pharmacokinetics of methotrexate in leukemia cells: Effect of dose and mode of injection

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

1978 • 707 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

FITTING EMPIRICAL DATA*

1960 • 188 citations

Transport and Binding of Methotrexate In Vivo

1973 • 147 citations

Energy metabolism, body size, and problems of scaling.

1970 • 146 citations

Preliminary Model for Methotrexate Pharmacokinetics

1970 • 111 citations

Bi-directional permeability of the human peritoneum to middle molecules.

1973 • 102 citations

The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.

1971 • 80 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

1976 • 64 citations

Comparative studies on the transport of aminopterin, methotrexate, and methasquin by the L1210 leukemia cell.

1972 • 50 citations

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

1976 • 42 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.

1975 • 38 citations

Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells.

1974 • 38 citations

Drug resistance and selectivity. Biochemical and cellular basis

1975 • 37 citations

Effects of selected cancer chemotherapeutic drugs on the survival times of mice with L-1210 leukemia: relative responses of antimetabolite resistant strains.

1962 • 33 citations

The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.

1974 • 29 citations

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models.

1976 • 29 citations

The kinetics of methotrexate distribution in spontaneous canine lymphosarcoma

1975 • 28 citations

Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine.

1973 • 24 citations

A basis for the difference in toxicity of methotrexate, aminopterin and methasquin in mice

1975 • 18 citations