Nucleosomes and transcription: recent lessons from genetics

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

Nucleosome Assembly by a Complex of CAF-1 and Acetylated Histones H3/H4

1996 • 624 citations

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

1996 • 623 citations

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.

1995 • 601 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Spreading of transcriptional represser SIR3 from telomeric heterochromatin

1996 • 523 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

The Major Cytoplasmic Histone Acetyltransferase in Yeast: Links to Chromatin Replication and Histone Metabolism

1996 • 429 citations

A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis.

1995 • 393 citations

Evidence That Spt6p Controls Chromatin Structure by a Direct Interaction with Histones

1996 • 352 citations

Identification of a Gene Encoding a Yeast Histone H4 Acetyltransferase

1995 • 341 citations

Linker Histone H1 Regulates Specific Gene Expression but Not Global Transcription In Vivo

1996 • 302 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

Linker histories are not essential and affect chromatin condensation in vivo

1995 • 300 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

ROLE OF CHROMATIN STRUCTURE IN THE REGULATION OF TRANSCRIPTION BY RNA POLYMERASE II

1994 • 276 citations

A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

1993 • 265 citations

Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription.

1995 • 245 citations

Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex

1996 • 227 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

HDA1 and HDA3 Are Components of a Yeast Histone Deacetylase (HDA) Complex

1996 • 189 citations

Identification of Human Proteins Functionally Conserved with the Yeast Putative Adaptors ADA2 and GCN5

1996 • 182 citations

Mice develop normally without the H1(0) linker histone.

1995 • 177 citations

SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.

1992 • 176 citations

Histone H4 and the maintenance of genome integrity.

1995 • 168 citations

A histone-binding protein, nucleoplasmin, stimulates transcription factor binding to nucleosomes and factor-induced nucleosome disassembly.

1994 • 150 citations

Histone acetylation in chromatin and chromosomes

1995 • 149 citations

Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo.

1993 • 144 citations

A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.

1995 • 132 citations

Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.

1996 • 132 citations

The p55 Subunit of Drosophila Chromatin Assembly Factor 1 Is Homologous to a Histone Deacetylase-Associated Protein

1996 • 130 citations

A New Class of Histone H2A Mutations in Saccharomyces cerevisiae Causes Specific Transcriptional Defects In Vivo

1995 • 108 citations

Chromatin-mediated transcription repression in yeast

1995 • 94 citations

All four core histone N-termini contain sequences required for the repression of basal transcription in yeast.

1996 • 90 citations

Yeast histone H2A and H2B amino termini have interchangeable functions

1986 • 88 citations

A Novel Histone H4 Mutant Defective in Nuclear Division and Mitotic Chromosome Transmission

1996 • 78 citations

Upstream Activation Sequence-Dependent Alteration of Chromatin Structure and Transcription Activation of the Yeast GAL1-GAL10 Genes

1989 • 76 citations

Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.

1995 • 74 citations

Faithful Chromosome Transmission Requires Spt4p, a Putative Regulator of Chromatin Structure in Saccharomyces cerevisiae

1996 • 66 citations

Regulation of gene expression by nucleosomes

1996 • 66 citations

Histone H1 inSaccharomyces cerevisiae: a double mystery solved?

1996 • 57 citations

The regulation of euchromatin and heterochromatin by histones in yeast

1995 • 54 citations

Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans

1996 • 52 citations

Yeast histone H3 and H4 N termini function through different GAL1 regulatory elements to repress and activate transcription.

1995 • 45 citations

Functional Analysis of Histones H2A and H2B in Transcriptional Repression in Saccharomyces cerevisiae

1996 • 41 citations

Upstream activation sequence-dependent alteration of chromatin structure and transcription activation of the yeast GAL1-GAL10 genes.

1989 • 36 citations

Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae

1996 • 34 citations

In vivo "photofootprint" changes at sequences between the yeast GAL1 upstream activating sequence and "TATA" element require activated GAL4 protein but not a functional TATA element.

1988 • 25 citations

Histone H1 in : a double mystery solved?

1996 • 17 citations