A random repertoire of V genes for T-cell receptors? Theoretical implications of recent experimental observations on T-cell specificity and self-restriction

Biology of the Mouse Histocompatibility-2 Complex

1975 • 1,145 citations

The somatic generation of immune recognition

1971 • 974 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO

1974 • 488 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES

1973 • 431 citations

Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of the frequency and specificity of precursors.

1977 • 357 citations

Lymphocyte Differentiation, Recognition, and Regulation

1977 • 320 citations

Thymus and Lymphohemopoietic Cells: Their Role in T Cell Maturation in Selection of T Cells' H‐2‐Restriction‐Specificity and in H‐2 Linked Ir Gene Control

1978 • 291 citations

H-2 Dependence of Co-Operation Between T and B Cells in Vivo

1972 • 285 citations

The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help.

1978 • 268 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors

1980 • 222 citations

Antigen Receptors of T Helper Cells

1977 • 200 citations

Two Different V_H Gene Products Make Up the T‐Cell Receptors

1976 • 179 citations

Role of H‐2 Gene Products in the Function of T Helper Cells from Normal and Chimeric Mice in Vivo¹

1978 • 153 citations

Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A‐strain specificity while infected cells confer cross‐reactive cytotoxicity

1977 • 150 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Collaboration of histoincompatible T and B lymphocytes using cells from tetraparental bone marrow chimeras.

1975 • 147 citations

Specificity of cytotoxic T cells from athymic mice.

1980 • 141 citations

Major Transplantation Antigens, Viruses, and Specificity of Surveillance T Cells

1977 • 135 citations

Evolution of the Immune Process in Vertebrates

1968 • 132 citations

Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization.

1975 • 125 citations

In Vitro Induction of Cytotoxicity against Syngeneic Mastocytoma and Its Suppression by Spleen and Thymus Cells from Tumor-Bearing Mice

1976 • 118 citations

Tumor metastases and cell‐mediated immunity in a model system in DBA/2 mice.: Iv. Antigenic differences between a metastasizing variant and the parental tumor line revealed by cytotoxic T lymphocytes

1979 • 115 citations

Quantitative studies on the precursors of cytotoxic lymphocytes. I. Characterization of a clonal assay and determination of the size of clones derived from single precursors.

1977 • 103 citations

The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens

1978 • 101 citations

T-cell inhibition of humoral responsiveness

1978 • 86 citations

QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

1971 • 86 citations

Regulation by the H-2 gene complex of delayed type hypersensitivity

1977 • 85 citations

The Influence of the Major Histocompatibility Complex on the Function of T‐Helper Cells in Antibody Formation

1978 • 58 citations

Quantitative Studies on the Precursors of Cytotoxic Lymphocytes

1977 • 48 citations

Generation of virus‐specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus‐specific cytotoxic T cells

1979 • 26 citations

T‐Cell Receptor Idiotypes

1980 • 18 citations

Quantitative studies on the precursors of cytotoxic lymphocytes. IV. Specificity and cross-reactivity of cytotoxic clones.

1978 • 17 citations

Role of self and foreign antigenic determinants in allogeneic and self-restricted cytotoxic T cell recognition.

1980 • 15 citations

Quantitative Studies on the Precursors of Cytotoxic Lymphocytes

1978 • 14 citations

The major influence on helper T cell cooperative partner cell preferences is exerted by the extrathymic environment.

1980 • 12 citations

Theoretical considerations and probability models for the somatic development of the T-cell repertoire

1981 • 11 citations