Mini ReviewRole of Hepatocyte Nuclear Factors in Growth Hormone-regulated, Sexually Dimorphic Expression of Liver Cytochromes P450*

STATs and Gene Regulation

1997 • 3,927 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

2004 • 1,293 citations

The Somatomedin Hypothesis: 2001

2001 • 1,184 citations

Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis

2001 • 1,066 citations

Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

1997 • 989 citations

Impaired Energy Homeostasis in C/EBPα Knockout Mice

1995 • 925 citations

Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule

1991 • 879 citations

SOCS Proteins: Negative Regulators of Cytokine Signaling

2001 • 807 citations

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

1994 • 550 citations

Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis

2003 • 548 citations

Liver‐enriched transcription factors and hepatocyte differentiation

1996 • 508 citations

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

2000 • 489 citations

Sex is a major determinant of CYP3A4 expression in human liver

2003 • 471 citations

How Important Are Gender Differences in Pharmacokinetics?

2002 • 430 citations

The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

2003 • 424 citations

Transcription factors in liver development, differentiation, and regeneration

2003 • 398 citations

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism

1997 • 394 citations

SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms

1999 • 364 citations

The onecut transcription factor HNF6 is required for normal development of the biliary tract

2002 • 359 citations

Signaling pathways activated by the growth hormone receptor

2001 • 326 citations

Coordination of PIC Assembly and Chromatin Remodeling During Differentiation-Induced Gene Activation

2002 • 301 citations

HNF4: A central regulator of hepatocyte differentiation and function

2003 • 281 citations

Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.

1992 • 279 citations

Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450.

1991 • 255 citations

Signal transduction via the growth hormone receptor

2001 • 249 citations

Intermittent Plasma Growth Hormone Triggers Tyrosine Phosphorylation and Nuclear Translocation of a Liver-Expressed, Stat 5-related DNA Binding Protein.

1995 • 242 citations

Gender differences in drug metabolism regulated by growth hormone

1995 • 227 citations

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: A study using adenovirus-mediated antisense targeting

2001 • 214 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 208 citations

A Cytosolic Protein-tyrosine Phosphatase PTP1B Specifically Dephosphorylates and Deactivates Prolactin-activated STAT5a and STAT5b

2000 • 183 citations

Protein Kinase A-Dependent Phosphorylation Modulates DNA-Binding Activity of Hepatocyte Nuclear Factor 4

1997 • 179 citations

Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression

1999 • 152 citations

SRC-1 and GRIP1 Coactivate Transcription with Hepatocyte Nuclear Factor 4

1998 • 146 citations

Sexual Dimorphism of Rat Liver Gene Expression: Regulatory Role of Growth Hormone Revealed by Deoxyribonucleic Acid Microarray Analysis

2003 • 143 citations

HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1)

2000 • 142 citations

Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3α-deficient mice

1999 • 141 citations

Transcriptional regulation of rat P-450 2C gene subfamily members by the sexually dimorphic pattern of growth hormone secretion.

1992 • 140 citations

Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression.

1988 • 138 citations

Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development

2003 • 137 citations

Sexually Dimorphic P450 Gene Expression in Liver-Specific Hepatocyte Nuclear Factor 4α-Deficient Mice

2004 • 135 citations

Constitutive expression of hepatic cytochrome P450 genes

1996 • 126 citations

Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans

2002 • 124 citations

Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors

2003 • 117 citations

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.

1994 • 117 citations

Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes.

1992 • 115 citations

Differential Effects of Neonatal and Adult Androgen Exposure on the Growth Hormone Secretory Pattern in Male Rats*

1987 • 115 citations

A Nuclear Protein Tyrosine Phosphatase TC-PTP Is a Potential Negative Regulator of the PRL-Mediated Signaling Pathway: Dephosphorylation and Deactivation of Signal Transducer and Activator of Transcription 5a and 5b by TC-PTP in Nucleus

2002 • 114 citations

Functional characterization of the L-type pyruvate kinase gene glucose response complex.

1993 • 113 citations

Hepatocyte Nuclear Factor 4 Expression Overcomes Repression of the Hepatic Phenotype in Dedifferentiated Hepatoma Cells

1997 • 111 citations

Plasma Growth Hormone Pulse Activation of Hepatic JAK-STAT5 Signaling: Developmental Regulation and Role in Male-Specific Liver Gene Expression

2000 • 110 citations

Involvement of STAT5 (Signal Transducer and Activator of Transcription 5) and HNF-4 (Hepatocyte Nuclear Factor 4) in the Transcriptional Control of the hnf6 Gene by Growth Hormone

2000 • 109 citations

Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.

1995 • 106 citations

Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone

1997 • 104 citations

STAT5b-deficient Mice Are Growth Hormone Pulse-resistant

1999 • 100 citations

Liver enriched transcription factors and differentiation of hepatocellular carcinoma

1999 • 92 citations

Pretranslational regulation of sex-dependent testosterone hydroxylases by growth hormone in mouse liver.

1986 • 89 citations

Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential.

1995 • 88 citations

Temporal Relationship Between the Sexually Dimorphic Spontaneous GH Secretory Profiles and Hepatic STAT5 Activity

2001 • 86 citations

Growth Hormone, but Not Prolactin, Maintains Low-Level Activation of STAT5a and STAT5b in Female Rat Liver

1999 • 84 citations

Janus Kinase 2-dependent Activation of p38 Mitogen-activated Protein Kinase by Growth Hormone

2000 • 83 citations

Neurophysiological regulation andtarget-tissue impact of the pulsatile mode of growth hormone secretion in the human

2001 • 79 citations

Synergistic Action of Hepatocyte Nuclear Factors 3 and 6 onCYP2C12 Gene Expression and Suppression by Growth Hormone-activated STAT5b

2000 • 73 citations

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

2003 • 70 citations

Differential expression of gender-dependent hepatic isoforms of cytochrome P-450 by pulse signals in the circulating masculine episodic growth hormone profile of the rat.

2000 • 69 citations

Gender Differences in the Responsiveness of the Sex-Dependent Isoforms of Hepatic P450 to the Feminine Plasma Growth Hormone Profile¹

1999 • 68 citations

Inhibitory Cross-talk between STAT5b and Liver Nuclear Factor HNF3β

2001 • 65 citations

A STAT Factor Mediates the Sexually Dimorphic Regulation of Hepatic Cytochrome P450 3A10/Lithocholic Acid 6β-Hydroxylase Gene Expression by Growth Hormone

1995 • 65 citations

Developmental Action of Estrogen Receptor-α Feminizes the Growth Hormone-Stat5b Pathway and Expression ofCyp2a4andCyp2d9Genes in Mouse Liver

1999 • 65 citations

Serine/Threonine Phosphorylation of Orphan Receptor Hepatocyte Nuclear Factor 4

1997 • 63 citations

Identification of Protein Tyrosine Phosphatases with Specificity for the Ligand-Activated Growth Hormone Receptor

2003 • 63 citations

Subnuclear Localization of C/EBPβ Is Regulated by Growth Hormone and Dependent on MAPK

2003 • 63 citations

A transcriptional regulatory element common to a large family of hepatic cytochrome P450 genes is a functional binding site of the orphan receptor HNF-4.

1994 • 62 citations

Intrinsic signals in the sexually dimorphic circulating growth hormone profiles of the rat

2001 • 56 citations

Growth hormone induces insulin‐like growth factor‐I gene transcription by a synergistic action of STAT5 and HNF‐1α

1999 • 46 citations

CCAAT/Enhancer-Binding Protein-α Is a Component of the Growth Hormone-Regulated Network of Liver Transcription Factors*

2000 • 42 citations

STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase

1998 • 40 citations

Cooperative Regulation of CYP2C12 Gene Expression by STAT5 and Liver-specific Factors in Female Rats

1999 • 39 citations

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

1985 • 36 citations

Involvement of Hepatocyte Nuclear Factor-4 in the Expression of the Growth Hormone Receptor 1A Messenger Ribonucleic Acid in Bovine Liver

2001 • 31 citations

Transcriptional regulation by HNF-4 of the steroid 15α-hydroxylase P450 (Cyp2a-4) gene in mouse liver

1997 • 30 citations

Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor

2003 • 28 citations

Hepatocyte nuclear factor 4 response to injury involves a rapid decrease in DNA binding and transactivation via a JAK2 signal transduction pathway

2002 • 26 citations

Growth Hormone (GH)-Releasing Factor (GRF) Pretreatment Enhances the GRF-Induced GH Secretion in Rats with the Pituitary Autotransplanted to the Kidney Capsule*

1985 • 24 citations

A specific cis-acting element regulates in vitro transcription of sex-dependent mouse steroid 16 alpha-hydroxylase (C-P450(16 alpha)) gene.

1990 • 21 citations

Male-specific transcription initiation of theC4-Slpgene in mouse liver follows activation of STAT5

1998 • 20 citations

IRE-ABP (Insulin Response Element-A Binding Protein), an SRY-Like Protein, Inhibits C/EBPα (CCAAT/Enhancer-Binding Proteinα )-Stimulated Expression of the Sex-Specific Cytochrome P450 2C12 Gene

1998 • 16 citations

Growth Hormone (GH)

2003 • 14 citations