The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

STATs in oncogenesis

2000 • 1,723 citations

Intrinsic tumour suppression

2004 • 1,267 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

2002 • 845 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

1999 • 798 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

1999 • 661 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

53BP1, a Mediator of the DNA Damage Checkpoint

2002 • 559 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

1998 • 426 citations

Ablation of the Retinoblastoma gene family deregulates G₁ control causing immortalization and increased cell turnover under growth-restricting conditions

2000 • 415 citations

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

2002 • 404 citations

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14^ARF Tumor Suppressor

2000 • 391 citations

Checking on the fork: the DNA-replication stress-response pathway

2002 • 340 citations

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation

2003 • 298 citations

Oncogenic ras and p53 Cooperate To Induce Cellular Senescence

2002 • 280 citations

Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

2003 • 260 citations

Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo

2003 • 239 citations

DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation

2006 • 232 citations

Role of p14^ARF in Replicative and Induced Senescence of Human Fibroblasts

2001 • 217 citations

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

2001 • 210 citations

Regulation of cellular response to oncogenic and oxidative stress by Seladin-1

2004 • 193 citations

Chk2 Activation and Phosphorylation-Dependent Oligomerization

2002 • 183 citations

High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

2004 • 171 citations

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.

1999 • 171 citations

Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

2003 • 148 citations

Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

2002 • 127 citations

Escape from premature senescence is not sufficient for oncogenic transformation by Ras

2001 • 101 citations

Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence

2004 • 90 citations

p19^ARF Is Dispensable for Oncogenic Stress-Induced p53-Mediated Apoptosis and Tumor Suppression In Vivo

2002 • 86 citations

PEA-15 Is Inhibited by Adenovirus E1A and Plays a Role in ERK Nuclear Export and Ras-induced Senescence

2004 • 55 citations

RNA Silencing of Checkpoint Regulators Sensitizesp53-Defective Prostate Cancer Cells to Chemotherapy while Sparing Normal Cells

2005 • 48 citations