In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

UCSF Chimera—A visualization system for exploratory research and analysis

2004 • 42,136 citations

Density Estimation for Statistics and Data Analysis

2018 • 15,477 citations

Electrostatics of nanosystems: Application to microtubules and the ribosome

2001 • 7,053 citations

ZINC − A Free Database of Commercially Available Compounds for Virtual Screening

2004 • 3,660 citations

DrugBank: a comprehensive resource for in silico drug discovery and exploration

2005 • 3,635 citations

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

1998 • 2,048 citations

The Ensembl genome database project

2002 • 1,606 citations

A Critical Assessment of Docking Programs and Scoring Functions

2005 • 1,538 citations

Comparative Evaluation of 11 Scoring Functions for Molecular Docking

2003 • 824 citations

Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search

2007 • 563 citations

Comparative evaluation of eight docking tools for docking and virtual screening accuracy

2004 • 555 citations

Clinical proteomics: translating benchside promise into bedside reality

2002 • 555 citations

Managing the drug discovery/development interface

1997 • 505 citations

Assessing Scoring Functions for Protein−Ligand Interactions

2004 • 464 citations

Advances in Homology Protein Structure Modeling

2006 • 448 citations

Molecular similarity analysis in virtual screening: foundations, limitations and novel approaches

2007 • 444 citations

Unexpected Nanomolar Inhibition of Carbonic Anhydrase by COX-2-Selective Celecoxib: New Pharmacological Opportunities Due to Related Binding Site Recognition

2003 • 438 citations

Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues

2004 • 407 citations

Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development

2005 • 377 citations

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema

2004 • 343 citations

Structural role of countertransport revealed in Ca²⁺pump crystal structure in the absence of Ca²⁺

2005 • 248 citations

eHiTS: A new fast, exhaustive flexible ligand docking system

2006 • 245 citations

High-Dose Oral Tamoxifen, a Potential Multidrug-Resistance-Reversal Agent: Phase I Trial in Combination With Vinblastine

1992 • 209 citations

Bridging Chemical and Biological Space: “Target Fishing” Using 2D and 3D Molecular Descriptors

2006 • 199 citations

Ligand binding: functional site location, similarity and docking

2003 • 194 citations

Biological spectra analysis: Linking biological activity profiles to molecular structure

2004 • 182 citations

Predicting ADME properties and side effects: the BioPrint approach.

2003 • 176 citations

Tamoxifen-associated eye disease. A review.

1996 • 167 citations

Analysis of drug-induced effect patterns to link structure and side effects of medicines

2005 • 156 citations

A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand binding sites

2007 • 141 citations

Centchroman, a selective estrogen receptor modulator, as a contraceptive and for the management of hormone‐related clinical disorders

2001 • 140 citations

Predicting undesirable drug interactions with promiscuous proteins in silico

2004 • 135 citations

Progress of Structural Genomics Initiatives: An Analysis of Solved Target Structures

2005 • 134 citations

Untitled

1400 • 131 citations

SERMs: Meeting the Promise of Multifunctional Medicines

2007 • 113 citations

Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum

2006 • 95 citations

Biospectra Analysis: Model Proteome Characterizations for Linking Molecular Structure and Biological Response

2005 • 92 citations

GPCR Antitarget Modeling: Pharmacophore Models for Biogenic Amine Binding GPCRs to Avoid GPCR-Mediated Side Effects

2005 • 89 citations

Origins, practices and future of safety pharmacology

2004 • 83 citations

Functional Coverage of the Human Genome by Existing Structures, Structural Genomics Targets, and Homology Models

2005 • 66 citations

Evaluation of docking programs for predicting binding of Golgi α‐mannosidase II inhibitors: A comparison with crystallography

2007 • 55 citations

The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene

2007 • 54 citations

In silico search of putative adverse drug reaction related proteins as a potential tool for facilitating drug adverse effect prediction

2006 • 46 citations

Progress toward virtual screening for drug side effects

2002 • 40 citations

Effects of anti‐oestrogens and β‐estradiol on calcium uptake by cardiac sarcoplasmic reticulum

2001 • 33 citations

Influence of hormones on platelet intracellular calcium

1995 • 31 citations

Tamoxifen inhibits Ca2+ uptake by the cardiac sarcoplasmic reticulum

2000 • 30 citations

Effect of the Anti‐Breast Cancer Drug Tamoxifen on Ca²⁺ Movement in Human Osteosarcoma Cells

2002 • 27 citations

Regulation of Sarco/Endoplasmic Ca2+-ATPase Expression by Calcium in Human Lens Cells

2002 • 26 citations

The effect of the anticancer drugs tamoxifen and hydroxytamoxifen on the calcium pump of isolated sarcoplasmic reticulum vesicles

1996 • 25 citations

Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells

2006 • 22 citations

Safety and efficacy of antiestrogens for prevention of breast cancer

2000 • 20 citations

Evaluating Chemical Structure Similarity as an Indicator of Cellular Growth Inhibition

2005 • 20 citations

Dual Effect of Tamoxifen, an Anti-Breast-Cancer Drug, on Intracellular Ca2+ and Cytotoxicity in Intact Cells

2000 • 15 citations

The anti-breast cancer drug tamoxifen alters Ca2+ movement in Chinese hamster ovary (CHO-K1) cells

2002 • 10 citations

Effects of Phytoestrogens on Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2a and Ca²⁺Uptake into Cardiac Sarcoplasmic Reticulum

2005 • 8 citations

Diethylstilbestrol increases intracellular calcium in lens epithelial cells

2005 • 7 citations

EHiTS 5.1.6

2005 • 4 citations