Dual Effect of Tamoxifen, an Anti-Breast-Cancer Drug, on Intracellular Ca2+ and Cytotoxicity in Intact Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Calcium signaling

1995 • 1,905 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

Elementary and global aspects of calcium signalling.

1997 • 1,031 citations

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.

1991 • 453 citations

Cooking with Calcium: The Recipes for Composing Global Signals from Elementary Events

1997 • 367 citations

Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase

1984 • 296 citations

Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells.

1997 • 139 citations

Antiestrogens – Tamoxifen, SERMs and Beyond

1999 • 125 citations

Calcium channel antagonist properties of the antineoplastic antiestrogen tamoxifen in the PC12 neurosecretory cell line.

1987 • 78 citations

Mechanism of lanthanum inhibition of extracellular ATP-evoked calcium mobilization in MDCK cells

1998 • 74 citations

Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells

1998 • 69 citations

Tamoxifen (estrogen antagonist) inhibits voltage-gated calcium current and contractility in vascular smooth muscle from rats.

1996 • 60 citations

Mechanism of rise and decay of thapsigargin-evoked calcium signals in MDCK cells

1998 • 55 citations

The phospholipase C inhibitor U73122 increases cytosolic calcium in MDCK cells by activating calcium influx and releasing stored calcium

1998 • 50 citations

Functional characterization of thapsigargin and agonist-insensitive acidic Ca2+stores in Drosophila melanogaster S2 cell lines

1999 • 47 citations

Tamoxifen Reduces Calcium Currents in a Clonal Pituitary Cell Line*

1988 • 38 citations

Activation of signal transduction kinases by tamoxifen.

1997 • 36 citations

Calcium antagonism by the antioestrogen tamoxifen

1986 • 29 citations

Effect of tamoxifen on carbachol-triggered intracellular calcium responses in chicken granulosa cells.

1994 • 22 citations

Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells

1999 • 22 citations

Fendiline increases [Ca2+]i in Madin Darby canine kidney (MDCK) cells by releasing internal Ca2+ followed by capacitative Ca2+ entry

2000 • 16 citations

Tamoxifen induces deregulation of [Ca2+] in human breast cancer cells.

1997 • 15 citations

The antitumor agent tamoxifen inhibits breakdown of polyphosphoinositides in GH4C1 cells.

1994 • 13 citations

The anti-oestrogen tamoxifen is a calcium antagonist in perfused rat mesentery

1987 • 11 citations

Tamoxifen inhibits prolactin signal transduction in ER− NOG-8 mammary epithelial cells

1997 • 9 citations