In vivo molecular-genetic imaging: multi-modality nuclear and optical combinations

A monomeric red fluorescent protein

2002 • 2,344 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

Advances in In Vivo Bioluminescence Imaging of Gene Expression

2002 • 863 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

BIOLUMINESCENCE

1998 • 542 citations

Optical imaging of Renilla luciferase reporter gene expression in living mice

2001 • 533 citations

Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases

2000 • 518 citations

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography

1999 • 459 citations

Imaging the expression of transfected genes in vivo.

1995 • 391 citations

Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.

1998 • 374 citations

Use of Reporter Genes for Optical Measurements of Neoplastic Disease In Vivo

2000 • 371 citations

Imaging Transgene Expression with Radionuclide Imaging Technologies

2000 • 368 citations

Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.

2002 • 265 citations

Quantification of target gene expression by imaging reporter gene expression in living animals

2000 • 228 citations

Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo

2001 • 222 citations

Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice.

2002 • 201 citations

Optical bioluminescence and positron emission tomography imaging of a novel fusion reporter gene in tumor xenografts of living mice.

2003 • 178 citations

Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction

2001 • 173 citations

Imaging TCR-Dependent NFAT-Mediated T-Cell Activation with Positron Emission Tomography In Vivo

2001 • 162 citations

Noninvasive quantitative imaging of protein–protein interactions in living subjects

2002 • 159 citations

Dual-colour imaging with GFP variants

1999 • 158 citations

Molecular-genetic imaging: current and future perspectives

2003 • 155 citations

Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy

1999 • 152 citations

Optical Imaging of Cardiac Reporter Gene Expression in Living Rats

2002 • 141 citations

Molecular Engineering of a Two-Step Transcription Amplification (TSTA) System for Transgene Delivery in Prostate Cancer

2002 • 124 citations

Tumor-specific transcriptional targeting of suicide gene therapy

2002 • 123 citations

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

1999 • 121 citations

A General Approach to the Non-Invasive Imaging of Transgenes Using Cis-Linked Herpes Simplex Virus Thymidine Kinase

1999 • 110 citations

The color of mice: in the light of GFP-variant reporters

2000 • 107 citations

Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells

1996 • 95 citations

COMMENTS ON THE MECHANISMS OF CHEMI‐ AND BIOLUMINESCENCE

1995 • 88 citations

Visualization of GFP-Expressing Tumors and Metastasis In Vivo

2001 • 77 citations

Gene transfer strategies for improving radiolabeled peptide imaging and therapy.

2000 • 68 citations

Dual-Function Reporter Protein for Analysis of Gene Expression in Living Cells

1998 • 65 citations

Green fluorescent protein as a reporter for gene transfer studies in the cochlea

1997 • 65 citations

Receptor-Binding Radiotracers

2019 • 64 citations

Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: A method to modulate gene expression

2002 • 61 citations

A Truncated Herpes Simplex Virus Thymidine Kinase Phosphorylates Thymidine and Nucleoside Analogs and Does Not Cause Sterility in Transgenic Mice

1995 • 60 citations

Cytoplasmically Retargeted HSV1-tk/GFP Reporter Gene Mutants for Optimization of Noninvasive Molecular-Genetic Imaging

2003 • 53 citations

High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells

2001 • 53 citations

In vivo imaging of molecular-genetic targets for cancer therapy

2003 • 52 citations

Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK

2000 • 48 citations

In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis

2000 • 48 citations

Imaging Expression of Cytosine Deaminase-Herpes Virus Thymidine Kinase Fusion Gene (CD/TK) Expression with [124I]FIAU and PET

2002 • 48 citations

Gene therapy with sodium/iodide symporter in hepatocarcinoma

2001 • 45 citations

High resolution, fluorescence deconvolution microscopy and tagging with the autofluorescent tracers CFP, GFP, and YFP to study the structural composition of gap junctions in living cells

2001 • 43 citations

Development of a New Reporter Gene System—dsRed/Xanthine Phosphoribosyltransferase-Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier

2003 • 36 citations

Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene.

1998 • 34 citations

In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis

2000 • 27 citations

Monitoring E-selectin-mediated adhesion using green and red fluorescent proteins

2003 • 14 citations

Receptor binding radiotracers: personal history of the past 20 years

2001 • 3 citations