Fertile homozygous transgenic mice expressing a functional truncated herpes simplex thymidine kinase delta TK gene.

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.

1986 • 3,231 citations

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

1978 • 560 citations

Transgenic mice with inducible dwarfism

1989 • 302 citations

Targeting of an inducible toxic phenotype in animal cells.

1988 • 252 citations

A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes

1992 • 251 citations

The biochemistry and mechanism of action of acyclovir

1983 • 211 citations

Lymphoma Regression Induced by Ganciclovir in Mice Bearing a Herpes Thymidine Kinase Transgene

1990 • 208 citations

Location of the mouse complement factor H gene (<i>cfh</i>) by FISH analysis and replication R-banding

1992 • 201 citations

Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency.

1989 • 178 citations

Position-dependent variegation of globin transgene expression in mice.

1995 • 159 citations

Variegated transgene expression in mouse mammary gland is determined by the transgene integration locus.

1996 • 153 citations

Human Gene Marker/Therapy Clinical Protocols (Complete Updated Listings)

2000 • 147 citations

Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information

1980 • 147 citations

Conditional Ablation of Cerebellar Astrocytes in Postnatal Transgenic Mice

1996 • 124 citations

Variegated gene expression in mice

1997 • 116 citations

Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.

1996 • 107 citations

Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population.

1992 • 101 citations

Infertility in Male Transgenic Mice: Disruption of Sperm Development by HSV-tk Expression in Postmeiotic Germ Cells1

1990 • 101 citations

Prevention of Graft-Versus-Host Disease in Mice Using a Suicide Gene Expressed in T Lymphocytes

1997 • 93 citations

The Herpes Simplex Virus Type 1 Thymidine Kinase Is Expressed in the Testes of Transgenic Mice under the Control of a Cryptic Promoter

1991 • 84 citations

Suppression of erythro-megakaryocytopoiesis and the induction of reversible thrombocytopenia in mice transgenic for the thymidine kinase gene targeted by the platelet glycoprotein alpha IIb promoter.

1995 • 80 citations

Male sterility of transgenic mice carrying exogenous mouse interferon-beta gene under the control of the metallothionein enhancer-promoter.

1988 • 67 citations

A Mup Promoter-Thymidine Kinase Reporter Gene Shows Relaxed Tissue-Specific Expression and Confers Male Sterility upon Transgenic Mice

1988 • 66 citations

A Truncated Herpes Simplex Virus Thymidine Kinase Phosphorylates Thymidine and Nucleoside Analogs and Does Not Cause Sterility in Transgenic Mice

1995 • 60 citations

Conditional ablation of dendritic cells in transgenic mice.

1994 • 55 citations

Anticellular Effects of 9-(2-Hydroxyethoxymethyl) Guanine Against Herpes Simplex Virus-transformed Cells

1979 • 55 citations

Transcriptional Insulation of the Human Keratin 18 Gene in Transgenic Mice

1993 • 52 citations

Specific Ablation of Thyroid Follicle Cells in Adult Transgenic Mice*

1991 • 49 citations

Inhibition of graft-versus-host disease. Use of a T cell-controlled suicide gene.

1997 • 48 citations

Inhibition of herpes simplex virus transformed and nontransformed cells by acycloguanosine: Mechanisms of uptake and toxicity

1981 • 46 citations

The selective ablation of interleukin 2-producing cells isolated from transgenic mice.

1993 • 46 citations

Characterization of an intronless CD4 minigene expressed in mature CD4 and CD8 T cells, but not expressed in immature thymocytes.

1996 • 46 citations

Delayed Morbidity and Mortality of Albumin/SV40 T-Antigen Transgenic Mice after Insertion of an α-Fetoprotein/Herpes Virus Thymidine Kinase Transgene and Treatment with Ganciclovir

1994 • 39 citations

Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland.

1995 • 33 citations

Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells.

1997 • 31 citations

Thy-1 tk transgenic mice with a conditional lymphocyte deficiency

1993 • 21 citations

Different transmission rates of herpesvirus thymidine kinase reporter transgenes from founder male parents and male parents of subsequent generations

1995 • 19 citations

Induced ablation of gonadotropins in transgenic mice expressing Herpes simplex virus thymidine kinase under the FSH β-subunit promoter

1995 • 14 citations

Initiation of herpes simplex virus thymidine kinase polypeptides

1996 • 9 citations