BIOLUMINESCENCE

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Modern Molecular Photochemistry

1978 • 4,940 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Extraction, Purification and Properties of Aequorin, a Bioluminescent Protein from the Luminous Hydromedusan, Aequorea

1962 • 2,210 citations

Crystal Structure of the Aequorea victoria Green Fluorescent Protein

1996 • 2,167 citations

Primary structure of the Aequorea victoria green-fluorescent protein

1992 • 2,135 citations

Wavelength mutations and posttranslational autoxidation of green fluorescent protein.

1994 • 1,773 citations

The molecular structure of green fluorescent protein

1996 • 1,549 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

Understanding, improving and using green fluorescent proteins

1995 • 1,350 citations

Resonance Energy Transfer: Methods and Applications

1994 • 1,245 citations

Cellular Control of the Synthesis and Activity of the Bacterial Luminescent System

1970 • 1,230 citations

CENSUS AND CONSENSUS IN BACTERIAL ECOSYSTEMS: The LuxR-LuxI Family of Quorum-Sensing Transcriptional Regulators

1996 • 1,203 citations

A conserved tripeptide sorts proteins to peroxisomes.

1989 • 1,113 citations

Structural identification of autoinducer of Photobacterium fischeri luciferase

1981 • 972 citations

Ultra-fast excited state dynamics in green fluorescent protein: multiple states and proton transfer.

1996 • 848 citations

Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence

1993 • 741 citations

Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein

1997 • 681 citations

Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes

1996 • 614 citations

Bioluminescence In Action

1979 • 461 citations

Chromophore Formation in Green Fluorescent Protein

1997 • 430 citations

Enzymatic Synthesis of a Quorum-Sensing Autoinducer Through Use of Defined Substrates

1996 • 406 citations

Energy transfer in a bioluminescent system

1971 • 388 citations

Chemiluminescence of organic peroxides. Conversion of ground-state reactants to excited-state products by the chemically initiated electron-exchange luminescence mechanism

1979 • 384 citations

Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.

1996 • 370 citations

Isolation and expression of a cDNA encoding Renilla reniformis luciferase.

1991 • 358 citations

Circadian Oscillations of Cytosolic and Chloroplastic Free Calcium in Plants

1995 • 351 citations

Symbiont Recognition and Subsequent Morphogenesis as Early Events in an Animal-Bacterial Mutualism

1991 • 330 citations

LESSONS FROM A COOPERATIVE, BACTERIAL-ANIMAL ASSOCIATION: The Vibrio fischeri–Euprymna scolopes Light Organ Symbiosis

1996 • 315 citations

Molecular biology of the symbiotic-pathogenic bacteria Xenorhabdus spp. and Photorhabdus spp

1996 • 302 citations

Fluorescence resonance energy transfer between blue-emitting and red-shifted excitation derivatives of the green fluorescent protein

1996 • 300 citations

Biological diversity, chemical mechanisms, and the evolutionary origins of bioluminescent systems

1983 • 280 citations

Complementary DNA Coding Click Beetle Luciferases Can Elicit Bioluminescence of Different Colors

1989 • 271 citations

Intracellular singlet oxygen generation by phagocytosing neutrophils in response to particles coated with a chemical trap.

1992 • 259 citations

A quorum-sensing system in the free-living photosynthetic bacterium Rhodobacter sphaeroides

1997 • 218 citations

Reactive oxygen species as cellular messengers

1995 • 218 citations

Growth and flagellation of Vibrio fischeri during initiation of the sepiolid squid light organ symbiosis

1993 • 207 citations

Evidence that the N-terminal region of the Vibrio fischeri LuxR protein constitutes an autoinducer-binding domain

1995 • 204 citations

THE CHEMICAL MECHANISM and EVOLUTIONARY DEVELOPMENT OF BEETLE BIOLUMINESCENCE

1995 • 200 citations

Energy transfer and organic photochemistry

1969 • 199 citations

Quantum efficiency of Cypridina luminescence, with a note on that of Aequorea

1962 • 196 citations

Spectral Properties of an Oxygenated Luciferase—Flavin Intermediate Isolated by Low-Temperature Chromatography

1973 • 194 citations

GENETICS OF BACTERIAL BIOLUMINESCENCE

1994 • 192 citations

Firefly luciferase is targeted to peroxisomes in mammalian cells.

1987 • 189 citations

Circadian regulation of bioluminescence in Gonyaulax involves translational control.

1989 • 186 citations

Quorum sensing in Vibrio fischeri: essential elements for activation of the luminescence genes

1997 • 183 citations

Bacterial symbionts induce host organ morphogenesis during early postembryonic development of the squid Euprymna scolopes

1994 • 164 citations

Crystal Structure and Photodynamic Behavior of the Blue Emission Variant Y66H/Y145F of Green Fluorescent Protein

1997 • 162 citations

Bioluminescence of the firefly: key steps in the formation of the electronically excited state for model systems.

1978 • 152 citations

Structure of dinoflagellate luciferin and its enzymic and nonenzymic air-oxidation products

1989 • 148 citations

Quorum sensing in Vibrio fischeri: evidence that S-adenosylmethionine is the amino acid substrate for autoinducer synthesis

1996 • 144 citations

A squid that glows in the night: development of an animal-bacterial mutualism

1992 • 143 citations

Isolation and characterization of mutants of firefly luciferase which produce different colors of light

1991 • 140 citations

Hydrophobic nature of the active site of firefly luciferase

1969 • 136 citations

The 1.5-Å Resolution Crystal Structure of Bacterial Luciferase in Low Salt Conditions

1996 • 136 citations

Electron transfer and chemiluminescence. Two inefficient systems: 1,4-dimethoxy-9,10-diphenylanthracene peroxide and diphenoyl peroxide

1989 • 134 citations

Bioluminescence in the symbiotic squid Euprymna scolopes is controlled by a daily biological rhythm

1996 • 114 citations

Bioluminescence

1968 • 111 citations

Luciferase from the East European firefly Luciola mingrelica: Cloning and nucleotide sequence of the cDNA, overexpression in Escherichia coli and purification of the enzyme

1993 • 110 citations

Molecular cloning and genomic organization of a gene for luciferin-binding protein from the dinoflagellate Gonyaulax polyedra.

1993 • 104 citations

Detection and quantification of Vibrio fischeri autoinducer from symbiotic squid light organs

1995 • 102 citations

Circadian expression of the luciferin-binding protein correlates with the binding of a protein to the 3' untranslated region of its mRNA.

1994 • 100 citations

Activation of a calcium-dependent photoprotein by chemical signalling through gap junctions

1987 • 96 citations

Three-dimensional structure of bacterial luciferase from Vibrio harveyi at 2.4 .ANG. resolution

1995 • 96 citations

Characterization of the bioluminescent organelles in Gonyaulax polyedra (dinoflagellates) after fast-freeze fixation and antiluciferase immunogold staining.

1987 • 93 citations

COMMENTS ON THE MECHANISMS OF CHEMI‐ AND BIOLUMINESCENCE

1995 • 88 citations

THE ORIGIN OF BIOLUMINESCENCE*

1975 • 85 citations

Synthesis of the lux gene autoinducer in Vibrio fischeri is positively autoregulated

1991 • 81 citations

Competition between Vibrio fischeri strains during initiation and maintenance of a light organ symbiosis

1994 • 80 citations

Identifications of the true carbon-13 nuclear magnetic resonance spectrum of the stable intermediate II in bacterial luciferase

1986 • 78 citations

Cloning and sequence analysis of cDNA for luciferase of a Japanese firefly, Luciola cruciata

1989 • 78 citations

A peroxidase related to the mammalian antimicrobial protein myeloperoxidase in the Euprymna–Vibrio mutualism

1996 • 78 citations

ENERGY TRANSFER VIA PROTEIN‐PROTEIN INTERACTION IN RENILLA BIOLUMINESCENCE

1978 • 77 citations

Bioelectric Control of Bioluminescence in the Dinoflagellate Noctiluca . I. Specific Nature of Triggering Events

1965 • 76 citations

The circadian bioluminescence rhythm of Gonyaulax is related to daily variations in the number of light-emitting organelles

1990 • 75 citations

BIOCHEMISTRY OF BACTERIAL BIOLUMINESCENCE

1995 • 72 citations

Dinoflagellate bioluminescence: A comparative study of invitro components

1976 • 72 citations

Bioluminescence and Biological Aspects of Brazilian Railroad-Worms (Coleoptera: Phengodidae)

1997 • 69 citations

MOLECULAR EVOLUTION OF THE Ca²⁺‐BINDING PHOTOPROTEINS OF THE HYDROZOA

1995 • 69 citations

Mechanism of bacterial bioluminescence: 4a,5-Dihydroflavin analogs as models for luciferase hydroperoxide intermediates and the effect of substituents at the 8-position of flavin on luciferase kinetics

1993 • 68 citations

Yellow light emission of Vibrio fischeri strain Y-1: purification and characterization of the energy-accepting yellow fluorescent protein.

1987 • 66 citations

In vitro energy transfer in Renilla bioluminescence

1976 • 65 citations

Compartmentalization of algal bioluminescence: autofluorescence of bioluminescent particles in the dinoflagellate Gonyaulax as studied with image-intensified video microscopy and flow cytometry.

1985 • 65 citations

Three functional luciferase domains in a single polypeptide chain

1997 • 63 citations

Growth and luminescence of the bacterium Xenorhabdus luminescens from a human wound

1989 • 63 citations

ANALOGS AND DERIVATIVES OF FIREFLY OXYLUCIFERIN, THE LIGHT EMITTER IN FIREFLY BIOLUMINESCENCE

1991 • 62 citations

Separation and structure of the prosthetic group of the blue fluorescence protein from the bioluminescent bacterium Photobacterium phosphoreum

1979 • 62 citations

Role of a luciferin-binding protein in the circadian bioluminescent reaction of Gonyaulax polyedra

1989 • 60 citations

Quorum sensing: a population-density component in the determination of bacterial phenotype

1996 • 59 citations

Lumisomes, the Cellular Site of Bioluminescence in Coelenterates

1973 • 58 citations

Imaging of luciferase secretion from transformed Chinese hamster ovary cells.

1992 • 57 citations

The structure and organization of the luciferase gene in the photosynthetic dinoflagellate Gonyaulax polyedra.

1998 • 56 citations

A homoserine lactone autoinducer regulates virulence of an insect-pathogenic bacterium, Xenorhabdus nematophilus (Enterobacteriaceae)

1997 • 55 citations

THE CIRCADIAN RHYTHM OF BIOLUMINESCENCE IN PYROCYSTIS IS NOT DUE TO DIFFERENCES IN THE AMOUNT OF LUCIFERASE: A COMPARATIVE STUDY OF THREE BIOLUMINESCENT MARINE DINOFLAGELLATES

1998 • 55 citations

Purification of the yellow fluorescent protein from vibrio fischeri and identity of the flavin chromophore

1987 • 54 citations

Intracellular generation of superoxide as a by-product of Vibrio harveyi luciferase expressed in Escherichia coli

1994 • 54 citations

Import of Firefly Luciferase into Mammalian Peroxisomes in Vivo Requires Nucleoside Triphosphates

1993 • 53 citations

A time-dependent bacterial bioluminescence emission spectrum in an in vitro single turnover system: energy transfer alone cannot account for the yellow emission of Vibrio fischeri Y-1.

1990 • 52 citations

Evolutionary origins of bacterial bioluminescence

1992 • 49 citations

Halovibrin, secreted from the light organ symbiont Vibrio fischeri, is a member of a new class of ADP-ribosyltransferases

1996 • 49 citations

Kinetic destabilization of the hydroperoxy flavin intermediate by site-directed modification of the reactive thiol in bacterial luciferase.

1993 • 46 citations

CIRCADIAN REGULATION OF BIOLUMINESCENCE IN THE DINOFLAGELLATE PYROCYSTIS LUNULA¹

1993 • 46 citations

REGULATORY CIRCUITRY CONTROLLING LUMINESCENCE AUTOINDUCTION IN Vibrio fischeri

1995 • 45 citations

Peroxisomes of the firefly lantern

1976 • 44 citations

The mRna Level of the Circadian RegulatedGonyaulaxLuciferase Remains Constant over the Cycle

1998 • 43 citations

Borrowed proteins in bacterial bioluminescence.

1991 • 42 citations

CHEMICAL ASPECTS OF BIOLUMINESCENCE

1995 • 40 citations

Bioluminescence as a Possible Auxiliary Oxygen Detoxifying Mechanism in Elaterid Larvae

1998 • 38 citations

Protein sequence homology between plant 4-coumarate: CoA llgase and firefly luciferase

1989 • 37 citations

POLYNOIDIN: A MEMBRANE PHOTOPROTEIN ISOLATED FROM THE BIOLUMINESCENT SYSTEM OF SCALE‐WORMS

1982 • 36 citations

Mechanism of the enzyme-catalyzed bioluminescent oxidation of coelenterate-type luciferin

1978 • 36 citations

Spectral detection of an intermediate preceding the excited state in the bacterial luciferase reaction

1993 • 34 citations

Retinal differences between light-tolerant and light-avoiding slugs (Mollusca: Pulmonata)

1975 • 34 citations

Isolation and characterization of the transient, luciferase-bound flavin-4a-hydroxide in the bacterial luciferase reaction

1987 • 34 citations

Cloning, sequencing and expression of dinoflagellate luciferase DNA from a marine alga, Gonyaulax polyedra

1994 • 33 citations

The ultrastructural localization of luciferase in three bioluminescent dinoflagellates, two species of Pyrocystis, and Noctiluca, using antiluciferase and immunogold labelling

1987 • 31 citations

The polypeptide components of scintillons, the bioluminescence organelles of the dinoflagellate Gonyaulax polyedra

1993 • 30 citations

Colocalization of luciferin binding protein and luciferase to the scintillons ofGonyaulax polyedra revealed by double immunolabeling after fast-freeze fixation

1991 • 29 citations

DISTRIBUTION OF SUBCELLULAR BIOLUMINESCENT SOURCES IN A DINOFLAGELLATE,PYROCYSTIS FUSIFORMIS

1982 • 28 citations

Expression of recombinant Renilla luciferase in transgenic plants results in high levels of light emission

1995 • 28 citations

The Mechanism of Bacterial Bioluminescence

2018 • 28 citations

Properties of 4a-hydroxy-4a,5-dihydroflavin radicals in relation to bacterial bioluminescence

1992 • 27 citations

Fine structure of the tracheoles of the lantern of a photurid firefly

1977 • 26 citations

A fine structure study of the anthocodium in Renilla mülleri. Evidence for the existence of a bioluminescent organelle, the luminelle.

1975 • 25 citations

[28] Cell-free components in dinoflagellate bioluminescence. The particulate activity: Scintillons; the soluble components: Luciferase, luciferin, and luciferin-binding protein

1986 • 25 citations

Two active forms of the accessory yellow fluorescence protein of the luminous bacterium Vibrio fischeri strain Y1

1993 • 23 citations

Targeting of cloned firefly luciferase to yeast mitochondria

1990 • 23 citations

THE EVOLUTION OF BIOLUMINESCENCE IN BACTERIA

1987 • 23 citations

Interaction of Photobacterium leiognathi and Vibrio fischeri Y1 Luciferases with Fluorescent (Antenna) Proteins: Bioluminescence Effects of the Aliphatic Additive

1996 • 22 citations

Direct Measurement of Excitation Transfer in the Protein Complex of Bacterial Luciferase Hydroxyflavin and the Associated Yellow Fluorescence Proteins from Vibrio fischeri Y1

1996 • 22 citations

Similar paracrystals of endoplasmic reticulum in the photoemitters and the photoreceptors of scale-worms

1978 • 21 citations

Bioluminescence from single bacterial cells exhibits no oscillation

1980 • 20 citations

A sensitive and specific assay for superoxide anion released by neutrophils or macrophages based on bioluminescence of polynoidin

1990 • 19 citations

Induction of adrenocortical special zone in the male possum (Trichosurus vulpecula)

1987 • 18 citations

Mechanism for iron control of the Vibrio fischeri luminescence system: Involvement of cyclic AMP and cyclic AMP receptor protein and modulation of DNA level

1992 • 17 citations

A transient intracellular coupling explains the facilitation of responses in the bioluminescent system of scale worms.

1987 • 16 citations

Differential translational initiation of lbp mRNA is caused by a 5′ upstream open reading frame¹

1997 • 16 citations

Structure and non‐enzymatic light emission of two luciferin precursors isolated from the luminous mushroom Panellus stipticus

1993 • 14 citations

SYMBIOTIC LUMINOUS SOIL BACTERIA: UNUSUAL REGULATION FOR AN UNUSUAL NICHE

1995 • 13 citations

A bacterial luciferase reaction with a negative temperature coefficient attributable to protein-protein interaction

1995 • 12 citations

Expression of the Renilla reniformis Luciferase Gene in Mammalian Cells

1996 • 11 citations

Expression and localization of bacterial luciferase determined by immunogold labeling

1989 • 11 citations

Mechanism of Bioluminescence

1982 • 11 citations

The widespread occurrence and tissue distribution of the imidazolopyrazine luciferins

1997 • 3 citations

Effectiveness of the Accessory Yellow Fluorescent Protein in the Bacterial Luciferase Reaction Correlates with the Lifetime of the Peroxyhemiacetal Intermediate: The Stereochemistry of the Reaction

1997 • 3 citations