The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

1995 • 93,704 citations

Statistical significance for genomewide studies

2003 • 9,411 citations

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

1980 • 8,270 citations

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

2003 • 8,039 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

The International HapMap Project

2003 • 5,951 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping

1989 • 3,180 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Serotonin Transporter Genetic Variation and the Response of the Human Amygdala

2002 • 2,332 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Schizophrenia as a Complex Trait

2003 • 2,253 citations

Analysis of Human Genetic Linkage.

1992 • 1,770 citations

A high-resolution recombination map of the human genome

2002 • 1,730 citations

Assessing the Probability That a Positive Report is False: An Approach for Molecular Epidemiology Studies

2004 • 1,720 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Sequential tests for the detection of linkage.

1955 • 1,590 citations

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

2003 • 1,522 citations

Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

2003 • 1,478 citations

Linkage strategies for genetically complex traits. I. Multilocus models.

1990 • 1,335 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Alzheimer's Disease and Parkinson's Disease

2003 • 1,277 citations

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

1996 • 1,201 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Mapping of a susceptibility locus for Crohn's disease on chromosome 16

1996 • 961 citations

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

2004 • 936 citations

Complete multipoint sib-pair analysis of qualitative and quantitative traits.

1995 • 929 citations

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

1990 • 886 citations

Bipolar affective disorders linked to DNA markers on chromosome 11

1987 • 826 citations

Analysis of Human Genetic Linkage

1999 • 755 citations

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

2000 • 745 citations

Two stage genome–wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12

1996 • 713 citations

A polygenic theory of schizophrenia.

1967 • 622 citations

Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland

1992 • 571 citations

The gene encoding phosphodiesterase 4D confers risk of ischemic stroke

2003 • 569 citations

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

1997 • 569 citations

Characterization of a Common Susceptibility Locus for Asthma-Related Traits

2004 • 489 citations

Apolipoprotein E and Alzheimer's Disease

1996 • 457 citations

Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury

1999 • 447 citations

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

1989 • 443 citations

Genetic linkage between X-chromosome markers and bipolar affective illness

1987 • 420 citations

Apolipoprotein E ∈4 Associated With Chronic Traumatic Brain Injury in Boxing

1997 • 414 citations

The genetic basis of common diseases.

2002 • 402 citations

Groups at risk in low birth weight infants and perinatal mortality.

1969 • 391 citations

Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1

1998 • 386 citations

The Human Phenome Project

2003 • 372 citations

A Second-Generation Genomewide Screen for Asthma-Susceptibility Alleles in a Founder Population

2000 • 335 citations

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

2003 • 325 citations

The Genetics of Schizophrenia

2005 • 325 citations

The genetic theory of schizophrenia. An analysis of 691 schizophrenic twin index families. 1946 [classical article]

1994 • 310 citations

The Genetics of Schizophrenia

1939 • 305 citations

A Genomewide Screen for Schizophrenia Genes in an Isolated Finnish Subpopulation, Suggesting Multiple Susceptibility Loci

1999 • 286 citations

THE GENETIC THEORY OF SCHIZOPHRENIA

1946 • 279 citations

Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent.

1993 • 264 citations

Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design

2001 • 258 citations

The transmission of schizophrenia under a multifactorial threshold model.

1983 • 256 citations

Linkage of Osteoporosis to Chromosome 20p12 and Association to BMP2

2003 • 256 citations

The role of APOE -ε4 in longitudinal cognitive decline

2003 • 250 citations

Screening the genome for rheumatoid arthritis susceptibility genes: A replication study and combined analysis of 512 multicase families

2003 • 241 citations

Localization of a Susceptibility Gene for Common Forms of Stroke to 5q12

2002 • 204 citations

Whole‐genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom

2002 • 203 citations

International Collaboration Provides Convincing Linkage Replication in Complex Disease through Analysis of a Large Pooled Data Set: Crohn Disease and Chromosome 16

2001 • 200 citations

Localization of a Susceptibility Gene for Type 2 Diabetes to Chromosome 5q34–q35.2

2003 • 197 citations

Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2

2003 • 196 citations

A New Approach to the Problem of Multiple Comparisons in the Genetic Dissection of Complex Traits

1998 • 186 citations

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

2003 • 186 citations

Genomewide Scan for Hand Osteoarthritis: A Novel Mutation in Matrilin-3

2003 • 181 citations

Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica

2003 • 179 citations

False Discovery Rate in Linkage and Association Genome Screens for Complex Disorders

2003 • 169 citations

Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigrees

1993 • 162 citations

Betting Odds and Genetic Associations

2004 • 157 citations

THE MAPPING OF HUMAN CHROMOSOMES

1971 • 142 citations

Statistical Inference From Genetic Data on Pedigrees

2000 • 139 citations

Measuring the inflation of the lod score due to its maximization over model parameter values in human linkage analysis

1990 • 137 citations

A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24

2002 • 127 citations

Power of variance component linkage analysis to detect quantitative trait loci.

1999 • 121 citations

Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986

1997 • 112 citations

A bias-ed assessment of the use of SNPs in human complex traits

2002 • 103 citations

Power of variance component linkage analysis to detect quantitative trait loci

1999 • 102 citations

Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland

2003 • 98 citations

Localization of a Gene for Migraine without Aura to Chromosome 4q21

2003 • 95 citations

Linkage of Essential Hypertension to Chromosome 18q

2002 • 93 citations

Genomewide Scan in Families with Schizophrenia from the Founder Population of Afrikaners Reveals Evidence for Linkage and Uniparental Disomy on Chromosome 1

2004 • 89 citations

Statistical methods for linkage analysis of complex traits from high-resolution maps of identity by descent.

1995 • 82 citations

The prior probability of autosomal linkage

1975 • 81 citations

Genomewide Linkage Disequilibrium Mapping of Severe Bipolar Disorder in a Population Isolate

2002 • 71 citations

Localization of a Gene for Peripheral Arterial Occlusive Disease to Chromosome 1p31

2002 • 65 citations

Association analysis of candidate genes for neuropsychiatric disease: the perpetual campaign

2002 • 59 citations

Positional Cloning by Linkage Disequilibrium

2004 • 57 citations

GenomEUtwin: A Strategy to Identify Genetic Influences on Health and Disease

2003 • 54 citations

Linkage Analysis of a Complex Pedigree with Severe Bipolar Disorder, Using a Markov Chain Monte Carlo Method

2001 • 50 citations

A Genome-Wide Search for Linkage-Disequilibrium With Type 1 Diabetes in a Recent Genetically Isolated Population From the Netherlands

2002 • 47 citations

Fine mapping of a multiple sclerosis locus to 2.5 Mb on chromosome 17q22-q24

2002 • 46 citations

The Genetic Basis of Common Diseases, 2nd Edition

2004 • 45 citations

The Runners-Up

2003 • 30 citations

The genetics of hereditary common cancers

1998 • 29 citations

The Genetic Basis of Common Diseases

1993 • 25 citations

Reply to “A call for accurate phenotype definition in the study of complex disorders”

2003 • 3 citations