Dissection of De Novo Membrane Insertion Activities of Internal Transmembrane Segments of ATP-Binding-Cassette Transporters: Toward Understanding Topological Rules for Membrane Assembly of Polytopic Membrane Proteins

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Intracellular protein topogenesis

1980 • 1,378 citations

Common Principles of Protein Translocation Across Membranes

1996 • 1,081 citations

Signal Sequence Recognition and Protein Targeting to the Endoplasmic Reticulum Membrane

1994 • 821 citations

Topogenic signals in integral membrane proteins

1988 • 715 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

Predicting the orientation of eukaryotic membrane-spanning proteins.

1989 • 596 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance

1993 • 290 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence

1988 • 185 citations

Topological ?frustration? in multispanning E. coli inner membrane proteins

1994 • 162 citations

Topological Rules for Membrane Protein Assembly in Eukaryotic Cells

1997 • 147 citations

The MDR superfamily of genes and its biological implications.

1994 • 140 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion

1994 • 134 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Mechanism of Polypeptide Translocation into the Endoplasmic Reticulum

1996 • 128 citations

Biogenesis of Polytopic Membrane Proteins: Membrane Segments Assemble within Translocation Channels prior to Membrane Integration

1996 • 123 citations

Multiple topogenic sequences in bovine opsin.

1987 • 115 citations

The erythrocyte anion transport protein is cotranslationally inserted into microsomes

1982 • 92 citations

Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

1995 • 86 citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

1993 • 82 citations

Biogenesis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an integral glycoprotein of the endoplasmic reticulum.

1984 • 80 citations

Structural requirements for membrane assembly of proteins spanning the membrane several times.

1989 • 79 citations

Decoding signals for membrane protein assembly using alkaline phosphatase fusions.

1991 • 73 citations

Membrane topology of multidrug resistance protein expressed in Escherichia coli. N-terminal domain.

1994 • 67 citations

Conformational changes of P-glycoprotein by nucleotide binding

1997 • 50 citations

Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).

1994 • 49 citations

In vitro biosynthesis, core glycosylation and membrane integration of opsin

1981 • 49 citations

Protein translocation at the ER membrane: A complex process becomes more so

1997 • 46 citations

Topological Determinants of Internal Transmembrane Segments in P-glycoprotein Sequences

1995 • 44 citations

Topological Folding and Proteolysis Profile of P-glycoprotein in Membranes of Multidrug-Resistant Cells: Implications for the Drug-Transport Mechanism

1996 • 40 citations

Biogenesis of Polytopic Membrane Proteins: Membrane Segments of P-glycoprotein Sequentially Translocate To Span the ER Membrane

1996 • 34 citations

Comparative Topology Studies in Saccharomyces cerevisiae and in Escherichia coli

1996 • 28 citations

Sequence requirements for membrane assembly of polytopic membrane proteins: molecular dissection of the membrane insertion process and topogenesis of the human MDR3 P-glycoprotein.

1996 • 28 citations

Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes

1996 • 28 citations

An amphipathic sequence determinant of membrane protein topology.

1994 • 26 citations