Role of Receptor Coupling to Phosphoinositide Metabolism in the Therapeutic Action of Lithium

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Society for Neuroscience 2007 abstracts

2007 • 2,107 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups

1975 • 1,216 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

A CHOLINERGIC-ADRENERGIC HYPOTHESIS OF MANIA AND DEPRESSION

1972 • 1,077 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation

1984 • 517 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats

1983 • 364 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Heterogeneity of presynaptic muscarinic receptors regulating neurotransmitter release in the rat brain.

1984 • 312 citations

Reduced Brain Inositol in Lithium-treated Rats

1971 • 309 citations

Evidence that Lithium Alters Phosphoinositide Metabolism: Chronic Administration Elevates Primarily <scp>d</scp>‐myo‐Inositol‐1‐Phosphate in Cerebral Cortex of the Rat

1981 • 273 citations

Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding

1986 • 267 citations

Neurobiology of Mood Disorders

1985 • 255 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

Requirement of Thymus-dependent Lymphocytes for Potentiation by Adjuvants of Antibody Formation

1971 • 245 citations

Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.

1985 • 199 citations

Handbook of Neurochemistry

1983 • 187 citations

Effects of Systemically Administered Lithium on Phosphoinositide Metabolism in Rat Brain, Kidney, and Testis

1985 • 186 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

The Biological Substrates of Alzheimerʼs Disease

1987 • 180 citations

Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation

1980 • 178 citations

Characterization of the cholinergic stimulation of phosphoinositide hydrolysis in rat brain slices

1984 • 175 citations

Effect of Lithium on the Uptake of Noradrenaline by Synaptosomes

1967 • 171 citations

Regional Alterations in Rat Brain Neurotransmitter Systems Following Chronic Lithium Treatment

1980 • 137 citations

Differential Stimulation of Inositol Phospholipid Turnover in Brain by Analogs of Oxotremorine

1984 • 134 citations

The effect of imipramine and lithium on α- and β-receptor binding in rat brain

1979 • 133 citations

EFFECTS OF ACETYLCHOLINE ON PHOSPHOLIPIDES IN THE PANCREAS

1954 • 122 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

The effect of prolonged lithium treatment on the synthesis rate and turnover of monoamines in brain regions of rats

1970 • 119 citations

The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation

1984 • 116 citations

Phorbol esters inhibit alpha1 adrenergic stimulation of glycogenolysis in isolated rat hepatocytes

1984 • 114 citations

The effects of lithium salts on the turnover and metabolism of norepinephrine in rat brain

1969 • 111 citations

EFFECTS OF LITHIUM TREATMENT IN VITRO AND IN VIVO ON ACETYLCHOLINE METABOLISM IN RAT BRAIN

1979 • 96 citations

Effect of Lithium on Circadian Neurotransmitter Receptor Rhythms

1982 • 93 citations

Characterization of neurotransmitter receptor-mediated phosphatidylinositol hydrolysis in the rat hippocampus

1984 • 86 citations

Studies on the role of brain cholinergic systems in the therapeutic mechanisms and adverse effects of ECT and lithium

1985 • 75 citations

Antidepressant Withdrawal Syndromes

1983 • 74 citations

Lithium effects on adrenergic receptor supersensitivity in rat brain

1979 • 63 citations

Effect of chronic lithium treatment on monoamine metabolism in rat brain

1973 • 62 citations

Role of inositol lipid breakdown in the generation of intracellular signals. State of the art lecture.

1986 • 60 citations

Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate

1985 • 54 citations

Inhibition of the effect of lithium on brain inositol by atropine and scopolamine

1976 • 54 citations

Effect of nomifensine and other antidepressant drugs on acetylcholine turnover in various regions of rat brain

1978 • 53 citations

Effect of lithium on content and uptake of norepinephrine and 5-hydroxytryptamine in mouse brain synaptosomes and mitochondria

1970 • 49 citations

Effect of lithium on the physostigmine-induced behavioral syndrome and plasma cyclic GMP

1979 • 48 citations

Phosphoprotein B-50 and phosphoinositides in brain synaptic plasma membranes: a possible feedback relationship

1986 • 36 citations

Catecholamine metabolism in the rat brain after short and long term lithium administration

1975 • 35 citations

The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation

1982 • 33 citations

Lethal effects of physostigmine plus lithium in rats

1977 • 33 citations

Effect of chronic lithium on cholinergically mediated responses and [3H]QNB binding in rat brain

1985 • 30 citations

Monoamine uptake into synaptosomes from various regions of rat brain following lithium administration and withdrawal

1981 • 27 citations

Chronic lithium prevents reserpine-induced supersensitivity of adenylate cyclase

1980 • 26 citations

Lithium's effects on muscarinic receptor binding parameters: a relationship to therapeutic efficacy?

1984 • 26 citations

Cholinergic Pathways in the Brain

1985 • 18 citations

LITHIUM AND BRAIN myo-INOSITOL METABOLISM

1978 • 17 citations

Comparison of acute and chronic lithium treatment on 3H-norepinephrine uptake by rat brain slices

1980 • 17 citations

Brain Cholinergic Systems and the Pathogenesis of Affective Disorders

1985 • 16 citations

Feedback control of the inositol phospholipid response in rat brain is sensitive to acth

1986 • 15 citations

Lithium administration antagonizes cholinergic behavioral effects in rodents

1979 • 13 citations

Effects of lithium chloride on the cholinergic system in different brain regions in mice

1980 • 12 citations

Receptor‐Coupled Hydrolysis of Phosphoinositides in Rat Hippocampal Slices: Muscarinic Versus Adrenergic

1987 • 1 citations