BRCA1 and BRCA2: different roles in a common pathway of genome protection

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

A census of human cancer genes

2004 • 3,190 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

2011 • 1,141 citations

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer

2001 • 1,020 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

2001 • 980 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

2006 • 802 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure

2002 • 679 citations

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

2007 • 678 citations

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

2002 • 671 citations

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

2007 • 660 citations

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

2001 • 655 citations

Purified human BRCA2 stimulates RAD51-mediated recombination

2010 • 641 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Tumour suppression by p53: a role for the DNA damage response?

2009 • 593 citations

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

2009 • 567 citations

Involvement of Brca1 in S-Phase and G₂-Phase Checkpoints after Ionizing Irradiation

2001 • 537 citations

Inherited Susceptibility to Common Cancers

2008 • 535 citations

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

2007 • 525 citations

A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes

1996 • 525 citations

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

2009 • 522 citations

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

2009 • 516 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

Genetic Steps of Mammalian Homologous Repair with Distinct Mutagenic Consequences

2004 • 473 citations

BRCA1 and its toolbox for the maintenance of genome integrity

2009 • 470 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

2011 • 455 citations

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

2005 • 449 citations

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1 -mutated basal-like breast cancer

2007 • 444 citations

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

1999 • 406 citations

Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair

2008 • 397 citations

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

1998 • 383 citations

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

2010 • 367 citations

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

1995 • 329 citations

Roles of BRCA1 and its interacting proteins

2000 • 318 citations

Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

2003 • 316 citations

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction

2005 • 315 citations

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

2010 • 315 citations

Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2

2004 • 314 citations

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

2006 • 305 citations

THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

1998 • 290 citations

Mutations and Polymorphisms in the familial early-onset breast cancer (BRCA1) gene

1996 • 288 citations

PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2

2009 • 287 citations

Direct DNA binding by Brca1

2001 • 277 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2

2007 • 264 citations

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

1997 • 253 citations

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

2009 • 246 citations

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

2010 • 246 citations

A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene

1995 • 243 citations

Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

2004 • 241 citations

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

2006 • 231 citations

Distinct molecular pathogeneses of early-onset breast cancers in BRCA1 and BRCA2 mutation carriers: a population-based study.

1999 • 229 citations

Differential Contributions ofBRCA1andBRCA2to Early-Onset Breast Cancer

1997 • 211 citations

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene

1999 • 198 citations

Linking the Cellular Functions ofBRCAGenes to Cancer Pathogenesis and Treatment

2008 • 197 citations

The etiology of breast cancer characteristic alterations in hydroxyl radical-induced dna base lesions during oncogenesis with potential for evaluating incidence risk

1993 • 197 citations

CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response

2007 • 195 citations

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

2002 • 187 citations

p53 mutation with frequent novel codons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1998 • 183 citations

Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.

2003 • 178 citations

Structural basis for recruitment of BRCA2 by PALB2

2009 • 174 citations

BRCA2 Mutation-associated Breast Cancers Exhibit a Distinguishing Phenotype Based on Morphology and Molecular Profiles From Tissue Microarrays

2006 • 164 citations

BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

2004 • 163 citations

Germline Brca2 Heterozygosity Promotes KrasG12D -Driven Carcinogenesis in a Murine Model of Familial Pancreatic Cancer

2010 • 159 citations

Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation

2000 • 153 citations

CCDC98 targets BRCA1 to DNA damage sites

2007 • 150 citations

BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks

2002 • 149 citations

Genomic profiling of breast tumours in relation to BRCAabnormalities and phenotypes

2009 • 146 citations

Nucleophosmin/B23 Is a Candidate Substrate for the BRCA1-BARD1 Ubiquitin Ligase

2004 • 144 citations

14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

2009 • 139 citations

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

2002 • 133 citations

DSS1 is required for the stability of BRCA2

2005 • 128 citations

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

2001 • 120 citations

ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

2006 • 120 citations

The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

2007 • 115 citations

The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells.

2001 • 113 citations

The BRCA2-Interacting Protein DSS1 Is Vital for DNA Repair, Recombination, and Genome Stability in Ustilago maydis

2003 • 112 citations

The metabolism of 17β-estradiol by lactoperoxidase: a possible source of oxidative stress in breast cancer

1994 • 108 citations

Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies

2009 • 108 citations

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions

1999 • 106 citations

Relative contributions of BRCA1 and BRCA2 mutations to “triple-negative” breast cancer in Ashkenazi Women

2011 • 99 citations

The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry

2009 • 97 citations

Minding the gap: The underground functions of BRCA1 and BRCA2 at stalled replication forks

2007 • 96 citations

Heterogenic Loss of the Wild-Type BRCA Allele in Human Breast Tumorigenesis

2007 • 95 citations

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions

2006 • 94 citations

Concomitant inactivation of p53 and Chk2 in breast cancer

2002 • 91 citations

Mammary tumor formation in p53- and BRCA1-deficient mice.

1999 • 85 citations

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1999 • 77 citations

A role for Brca1 in chromosome end maintenance

2006 • 76 citations

Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80

2008 • 73 citations

Inactivation of Brca2 Promotes Trp53-Associated but Inhibits KrasG12D-Dependent Pancreatic Cancer Development in Mice

2011 • 71 citations

CeBRC-2 Stimulates D-loop Formation by RAD-51 and Promotes DNA Single-strand Annealing

2006 • 67 citations

Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

2009 • 66 citations

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

1999 • 64 citations

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

2010 • 64 citations

Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer

2011 • 55 citations

THE ETIOLOGY OF BREAST CANCER

1932 • 50 citations

Knockout mouse models and mammary tumorigenesis

2001 • 50 citations

Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

2004 • 48 citations

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.

2002 • 45 citations

Depletion of DSS1 protein disables homologous recombinational repair in human cells

2010 • 38 citations

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

2011 • 33 citations

Increased Oxidative DNA Damage in Mammary Tumor Cells by Continuous Epidermal Growth Factor Stimulation

2001 • 21 citations

Spontaneous and Irradiation-Induced Tumor Susceptibility in Brca2 Germline Mutant Mice and Cooperative Effects with a p53 Germline Mutation

2006 • 17 citations