CCDC98 targets BRCA1 to DNA damage sites

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

2002 • 1,676 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

BRCA1 and BRCA2: 1994 and beyond

2004 • 941 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

1996 • 734 citations

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

2004 • 689 citations

Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response

2007 • 678 citations

RAP80 Targets BRCA1 to Specific Ubiquitin Structures at DNA Damage Sites

2007 • 660 citations

BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function

2001 • 655 citations

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

2003 • 644 citations

In search of the tumour-suppressor functions of BRCA1 and BRCA2

2000 • 638 citations

Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

2007 • 525 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

2002 • 473 citations

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.

2001 • 471 citations

DNA Damage-Induced Cell Cycle Checkpoint Control Requires CtIP, a Phosphorylation-Dependent Binding Partner of BRCA1 C-Terminal Domains

2004 • 391 citations

The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression

1998 • 383 citations

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

1999 • 351 citations

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

2000 • 327 citations

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

2006 • 305 citations

The BRCA1/BARD1 Heterodimer Assembles Polyubiquitin Chains through an Unconventional Linkage Involving Lysine Residue K6 of Ubiquitin

2003 • 291 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

2000 • 247 citations

The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair

2003 • 243 citations

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

2004 • 236 citations

Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

2003 • 227 citations

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

2004 • 224 citations

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

2002 • 218 citations

Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein

2003 • 199 citations

Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage

1999 • 192 citations

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

2001 • 186 citations

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

2004 • 165 citations

Characterization of a carboxy-terminal BRCA1 interacting protein

1998 • 163 citations

Structural Basis of BACH1 Phosphopeptide Recognition by BRCA1 Tandem BRCT Domains

2004 • 93 citations

The DNA double-strand break response pathway: becoming more BRCAish than ever

2004 • 68 citations

BRCA1 and Chk1 in G2/M Checkpoint: A New Order of Regulation

2002 • 12 citations