Immunological evidence for two physiological forms of protein kinase C.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Silver staining of proteins in polyacrylamide gels

1981 • 3,565 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.

1983 • 601 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

[43] Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle

1974 • 496 citations

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

1985 • 446 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

1985 • 386 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Identification of the NH₂‐terminal blocking group of calcineurin B as myristic acid

1982 • 312 citations

Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum.

1985 • 301 citations

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

1983 • 292 citations

Purification to homogeneity of protein kinase C from bovine brain-identity with the phorbol ester receptor.

1984 • 283 citations

Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

1984 • 278 citations

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.

1985 • 274 citations

Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C

1985 • 255 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain

1984 • 241 citations

Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties.

1982 • 235 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

The involvement of calpain in the activation of protein kinase C in neutrophils stimulated by phorbol myristic acid.

1986 • 228 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.

1985 • 220 citations

Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes

1985 • 201 citations

Polyclonal antibodies to phospholipid/Ca2+-dependent protein kinase and immunocytochemical localization of the enzyme in rat brain.

1985 • 193 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.

1986 • 173 citations

Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.

1983 • 160 citations

Evidence that treatment of platelets with phorbol ester causes proteolytic activation of Ca²⁺‐activated, phospholipid‐dependent protein kinase

1985 • 121 citations

Covalently bound myristate in a lymphoma tyrosine protein kinase.

1984 • 120 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

Hormonal regulation of a calcium-activated, phospholipid-dependent protein kinase in bovine adrenal cortex.

1984 • 112 citations

Modulation of Ca2+-activated, phospholipid-dependent protein kinase in platelets treated with a tumor-promoting phorbol ester

1984 • 109 citations

Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.

1984 • 104 citations

The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes.

1986 • 96 citations

Characterization of pituitary calcium-activated, phospholipid-dependent protein kinase: redistribution by gonadotropin-releasing hormone.

1985 • 90 citations

Translocation of phospholipid/Ca2+-dependent protein kinase in B-lymphocytes activated by phorbol ester or cross-linking of membrane immunoglobulin

1986 • 85 citations

Changes in phosphatidylinositol metabolism correlated to growth state of normal and Rous sarcoma virus-transformed Japanese quail cells.

1977 • 85 citations

Microheterogeneity of type II cAMP-dependent protein kinase in various mammalian species and tissues.

1984 • 81 citations

Cytosolic calcium regulates phorbol diester binding affinity in intact phagocytes.

1986 • 76 citations

Platelet Ca2+-activated, phospholipid-dependent protein kinase: Evidence for proteolytic activation of the enzyme in cells treated with phospholipase C

1984 • 74 citations

Redistribution of protein kinase C during mitogenesis of human B lymphocytes

1986 • 68 citations

Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus.

1985 • 61 citations

Altered catalytic properties of protein kinase C in phorbol ester treated cells

1986 • 60 citations

Characteristics of the adenohypophyseal Ca2+-phospholipid-dependent protein kinase

1984 • 56 citations

Proteolytic activation of protein kinase C by membrane-bound protease in rat liver plasma membrane

1985 • 25 citations

Protease-activated protein kinase in rat liver plasma membrane

1985 • 12 citations

Deleted Work

1955 • 0 citations