p53 and ras Gene Mutations in Lung Cancer: Implications for Smoking and Occupational Exposures

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

p53 function and dysfunction

1992 • 1,918 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

1990 • 643 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Detection of p53 Gene Mutations in Human Brain Tumors by Single-strand Conformation Polymorphism Analysis of Polymerase Chain Reaction Products

1991 • 556 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

1988 • 458 citations

The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis

1994 • 428 citations

Detection of oncogene mutations in sputum precedes diagnosis of lung cancer

1994 • 403 citations

Clinical significance of ras oncogene activation in human lung cancer

1993 • 361 citations

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

1989 • 338 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

1992 • 298 citations

p53 Mutations in non-small cell lung cancer in Japan: Association between mutations and smoking

1992 • 280 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Mutations of the p53 Gene as a Predictor of Poor Prognosis in Patients With Non-Small-Cell Lung Cancer

1993 • 213 citations

High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors

1993 • 207 citations

p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers

1994 • 199 citations

The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern

1992 • 199 citations

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

1992 • 198 citations

K‐ ras oncogene activation in lung adenocarcinomas from former smokers evidence that K‐ ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung

1993 • 187 citations

Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.

1993 • 170 citations

Genetic instability of microsatellite sequences in many non-small cell lung carcinomas

1994 • 167 citations

SHORT COMMUNICATION: G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and relati DNA methylating and pyridyloxobutylating agents

1993 • 151 citations

Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells

1990 • 151 citations

K‐ras mutations in human adenocarcinoma of the lung: Association with smoking and occupational exposure to asbestos

1993 • 140 citations

p53 Alterations in non-small cell lung cancers correlate with metastatic involvement of hilar and mediastinal lymph nodes

1994 • 133 citations

Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

1987 • 130 citations

The Molecular Biology of Lung Cancer Pathogenesis

1993 • 116 citations

Alterations of the p53 gene are common and critical events for the maintenance of malignant phenotypes in small-cell lung carcinoma.

1992 • 116 citations

Does a genotoxic carcinogen contribute to human breast cancer?

1993 • 94 citations

Overexpression of the p53 Tumor Suppressor Gene Product in Primary Lung Adenocarcinomas Is Associated with Cigarette Smoking

1993 • 90 citations

ras Oncogene Activation and Occupational Exposures in Acute Myeloid Leukemia

1992 • 83 citations

Comparison of pulmonary DNA adduct levels, measured by ³²P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers

1991 • 81 citations

Polycyclic Aromatic Hydrocarbons: Chemistry of DNA Adduct Formation

1995 • 77 citations

Comparison of pulmonary O⁶‐methylguanine dna adduct levels and Ki‐ras activation in lung tumors from resistant and susceptible mouse strains

1993 • 73 citations

Activated protooncogenes in human lung tumors from smokers.

1991 • 73 citations

Chromosome abnormalities in human non-small cell lung cancer.

1992 • 70 citations

Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice

1993 • 70 citations

Asbestos exposure and the risk of lung cancer in a general urban population.

1994 • 67 citations

p53 from basic research to clinical applications.

1992 • 67 citations

Mutational spectrum of the p53 gene in human small-cell lung cancer and relationship to clinicopathological data

1994 • 55 citations

p53 protein accumulation in lung carcinomas of patients exposed to asbestos and tobacco smoke.

1994 • 43 citations

Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas

1993 • 40 citations

GENETIC ALTERATIONS IN P53 AND K-RAS IN LUNG-CANCER IN RELATION TO HISTOPATHOLOGY OF THE TUMOR AND SMOKING HISTORY OF THE PATIENT

1994 • 34 citations