Leptin in the CNS: much more than a satiety signal

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin Inhibits Bone Formation through a Hypothalamic Relay

2000 • 2,045 citations

Leptin-regulated endocannabinoids are involved in maintaining food intake

2001 • 1,557 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Leptin

2000 • 1,368 citations

Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans

1997 • 1,299 citations

Cytokine receptor signalling

1995 • 1,242 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

A leptin missense mutation associated with hypogonadism and morbid obesity

1998 • 1,187 citations

From Lesions to Leptin

1999 • 1,165 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Leptin is a metabolic signal to the reproductive system.

1996 • 1,037 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1998 • 969 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 • 800 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

Leptin Regulation of Neuroendocrine Systems

2000 • 769 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Cognition and synaptic plasticity in diabetes mellitus

2000 • 765 citations

Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

1998 • 753 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

The Role of SOCS-3 in Leptin Signaling and Leptin Resistance

1999 • 640 citations

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

1997 • 631 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting.

1996 • 552 citations

SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

2000 • 531 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta

1997 • 518 citations

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

2001 • 506 citations

Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats

2000 • 501 citations

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

2002 • 422 citations

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

2001 • 396 citations

Leptin Suppression of Insulin Secretion by the Activation of ATP-Sensitive K+ Channels in Pancreatic β-Cells

1997 • 386 citations

Leptin is a metabolic signal to the reproductive system

1996 • 344 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development*

1999 • 320 citations

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

1997 • 315 citations

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

1996 • 257 citations

Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity

2002 • 252 citations

Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

2000 • 243 citations

Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus

1998 • 241 citations

Leptin Action in Intestinal Cells

1998 • 237 citations

Reproductive Hormonal Function in the Genetically Obese (ob/ob) Mouse

1976 • 217 citations

Leptin stimulates glucose transport and glycogen synthesis in C 2 C 12 myotubes: evidence for a PI3-kinase mediated effect

1997 • 207 citations

Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

1999 • 204 citations

A novel leptin receptor isoform in rat

1996 • 196 citations

Leptin-Induced Nuclear Translocation of STAT3 Immunoreactivity in Hypothalamic Nuclei Involved in Body Weight Regulation

2001 • 192 citations

Selective interaction between leptin and insulin signaling pathways in a hepatic cell line

2000 • 189 citations

Leptin Induces Mitogen-activated Protein Kinase- dependent Proliferation of C3H10T1/2 Cells

1997 • 187 citations

Leptin inhibits epileptiform‐like activity in rat hippocampal neurones via PI 3‐kinase‐driven activation of BK channels

2002 • 181 citations

Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor

1998 • 177 citations

Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

1999 • 172 citations

The suppressors of cytokine signalling (SOCS)

2001 • 166 citations

Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus - relationship with NPY neurones

1996 • 164 citations

A Role for Leptin in Brain Development

1999 • 158 citations

Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin

2000 • 151 citations

Altered neuroanatomical organization in the central nervous system of the genetically obese (ob/ob) mouse

1979 • 147 citations

Essential Role of Phosphoinositide 3-Kinase in Leptin-inducedK ATP Channel Activation in the Rat CRI-G1 Insulinoma Cell Line

2000 • 141 citations

Leptin Receptor Signal Transduction: OBRa and OBRb offaType

1998 • 140 citations

Leptin Decreases Food Intake Induced by Melanin-Concentrating Hormone (MCH), Galanin (GAL) and Neuropeptide Y (NPY) in the Rat

1998 • 137 citations

Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage

1997 • 134 citations

Leptin Induces Proliferation of Pancreatic β Cell Line MIN6 through Activation of Mitogen-Activated Protein Kinase

1997 • 134 citations

Leptin directly acts within the hypothalamus to stimulate gonadotropin‐releasing hormone secretion in vivo in rats

2002 • 119 citations

Leptin<sub>116–130</sub> Stimulates Prolactin and Luteinizing Hormone Secretion in Fasted Adult Male Rats

1999 • 109 citations

Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin.

1999 • 105 citations

Leptin activates ATP‐sensitive potassium channels in the rat insulin‐secreting cell line, CRI‐G1

1997 • 103 citations

Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

2001 • 98 citations

Leptin Controls Bone Formation Through a Hypothalamic Relay

2001 • 97 citations

Glucose‐receptive neurones in the rat ventromedial hypothalamus express K_ATP channels composed of Kir6.1 and SUR1 subunits

1999 • 90 citations

Leptin and the Neuroendocrinology of Fasting

1999 • 89 citations

Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels

2002 • 85 citations

Leptin depolarizes rat hypothalamic paraventricular nucleus neurons

1998 • 84 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development

1999 • 83 citations

Brain myelin of genetically obese mice

1985 • 77 citations

Functional Properties of Leptin Receptor Isoforms Containing the Gln→Pro Extracellular Domain Mutation of the Fatty Rat*

1998 • 76 citations

Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus

1998 • 73 citations

Leptin activation of ATP‐sensitive K⁺ (K_ATP) channels in rat CRI‐G1 insulinoma cells involves disruption of the actin cytoskeleton

2000 • 71 citations

The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin

1999 • 68 citations

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

1997 • 66 citations

Altered dendritic orientation of hypothalamic neurons from genetically obese (ob/ob) mice

1980 • 63 citations

Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells

1997 • 63 citations

Characterizaton of Short Isoforms of the Leptin Receptor in Rat Cerebral Microvessels and of Brain Uptake of Leptin in Mouse Models of Obesity

2002 • 53 citations

Leptin Decreases Food Intake Induced by Melanin-Concentrating Hormone (MCH), Galanin (GAL) and Neuropeptide Y (NPY) in the Rat

1998 • 51 citations

Insulin occludes leptin activation of ATP‐sensitive K⁺ channels in rat CRI‐G1 insulin secreting cells

1998 • 30 citations

Functional Properties of Leptin Receptor Isoforms Containing the Gln->Pro Extracellular Domain Mutation of the Fatty Rat

1998 • 20 citations

Phosphoinositide 3-kinase: the key switch in insulin signalling

1998 • 16 citations

Deleted Work

1955 • 0 citations