Characterization of melanin concentrating hormone and preproorexin expression in the murine hypothalamus

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

1998 • 3,711 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Narcolepsy in orexin Knockout Mice

1999 • 3,014 citations

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

1999 • 2,583 citations

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

1997 • 1,835 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

A role for melanin-concentrating hormone in the central regulation of feeding behaviour

1996 • 1,301 citations

Hypothalamic CART is a new anorectic peptide regulated by leptin

1998 • 1,283 citations

Orexin A activates locus coeruleus cell firing and increases arousal in the rat

1999 • 1,182 citations

From Lesions to Leptin

1999 • 1,165 citations

Mice lacking melanin-concentrating hormone are hypophagic and lean

1998 • 1,139 citations

The melanin‐concentrating hormone system of the rat brain: An immuno‐ and hybridization histochemical characterization

1992 • 1,052 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

1997 • 837 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

1998 • 797 citations

Obesity and the Hypothalamus: Novel Peptides for New Pathways

1998 • 448 citations

The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin

1999 • 438 citations

Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

1997 • 425 citations

Melanin-Concentrating Hormone Acutely Stimulates Feeding, But Chronic Administration Has No Effect on Body Weight

1997 • 416 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

2000 • 338 citations

Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat

1999 • 309 citations

Torpor in mice is induced by both leptin-dependent and -independent mechanisms

1999 • 206 citations

Distribution and quantification of immunoreactive orexin A in rat tissues

1999 • 177 citations

Down regulation of the prepro-orexin gene expression in genetically obese mice

1999 • 156 citations

Widespread Distribution of Orexin in Rat Brain and Its Regulation upon Fasting

1999 • 152 citations

Leptin selectively increases energy expenditure of food-restricted lean mice

1998 • 147 citations

The melanin-concentrating hormone: from the peptide to the gene.

1994 • 147 citations

Characterization of Expression of Hypothalamic Appetite-Regulating Peptides in Obese Hyperleptinemic Brown Adipose Tissue-Deficient (Uncoupling Protein-Promoter-Driven Diphtheria Toxin A) Mice¹

1998 • 83 citations

Severe Leptin Resistance in Brown Fat-Deficient Uncoupling Protein Promoter-Driven Diphtheria Toxin A Mice Despite Suppression of Hypothalamic Neuropeptide Y and Circulating Corticosterone Concentrations

1998 • 67 citations

Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland

1991 • 58 citations

Effects of Leptin on Melanin-Concentrating Hormone Expression in the Brain of Lean and Obese Lep<sup>ob</sup>/Lep<sup>ob</sup> Mice

1999 • 58 citations