TCR ligation on CD8+ T cells creates double-negative cells in vivo.

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Apoptosis of T cells mediated by galectin-1

1995 • 1,056 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

The Roles of Fas/APO-1 (CD95) and TNF in Antigen-Induced Programmed Cell Death in T Cell Receptor Transgenic Mice

1996 • 325 citations

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

1994 • 291 citations

The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

1993 • 210 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

Strange brew: T cells in the liver

1996 • 163 citations

Kupffer Cells: Their Activation and Role in Animal Models of Liver Injury and Human Liver Disease

1993 • 160 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.

1996 • 141 citations

Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion

1994 • 140 citations

Fatal interactions: fas-induced apoptosis of mature T cells

1994 • 118 citations

Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism.

1997 • 99 citations

Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I.

1995 • 96 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin.

1995 • 79 citations

Homeostatic regulation of CD8⁺ T cells after antigen challenge in the absence of Fas (CD95)

1996 • 70 citations

T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice.

1992 • 65 citations

Proliferation and apoptosis of B220⁺ CD4⁻CD8⁻TCRαβ^intermediate T cells in the liver of normal adult mice: implication for Ipr pathogenesis

1994 • 65 citations

Reduced development of CD4⁻8⁻B220⁺ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules

1995 • 64 citations

Altered expression of self-reactive T cell receptor V beta regions in autoimmune mice.

1990 • 60 citations

In CD8+ T cell-deficient lpr/lpr mice, CD4+B220+ and CD4+B220- T cells replace B220+ double-negative T cells as the predominant populations in enlarged lymph nodes.

1995 • 53 citations

Multiple sites of post‐activation CD8⁺ T cell disposal

1997 • 44 citations

MRL-lpr/lpr disease: theories meet Fas

1994 • 43 citations

Defective clonal deletion and anergy induction in TCR transgenic lpr/lpr mice

1994 • 27 citations

Liver-Associated Lymphocytes: Role in Tumor Defense

1993 • 23 citations