Antitumor effects of SMANCS on rat mammary tumor induced by 7,12-dimethylbenz[a]anthracene.

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

2001 • 644 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

1989 • 576 citations

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

1983 • 332 citations

Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image.

1984 • 283 citations

A New Approach to Cancer Chemotherapy: Selective Enhancement of Tumor Blood Flow With Angiotensin II<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 268 citations

Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium

1984 • 230 citations

Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties

1985 • 221 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

A LIPOPHILIC DERIVATIVE OF NEOCARZINOSTATIN A Polymer Conjugation of an Antitumor Protein Antibiotic*

1979 • 151 citations

Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

1988 • 127 citations

Increased Vascular Permeability in Organs Mediated by the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Mice

1988 • 115 citations

Tailor-making of protein drugs by polymer conjugation for tumor targeting: A brief review on smancs

1984 • 110 citations

Kinin‐generating Cascade in Advanced Cancer Patients and in vitro Study

1991 • 103 citations

Protein Binding of Macromolecular Anticancer Agent SMANCS: Characterization of Poly(styrene-co-maleic acid) Derivatives as an Albumin Binding Ligand

1988 • 59 citations

Binding to and internalization by cultured cells of neocarzinostatin and enhancement of its actions by conjugation with lipophilic styrene-maleic acid copolymer.

1987 • 54 citations

Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver.

1987 • 47 citations

Stimulation of Macrophage by Polyanions and Its Conjugated Proteins and Effect on Cell Membrane

1986 • 37 citations

Facilitated internalization of neocarzinostatin and its lipophilic polymer conjugate, SMANCS, into cytosol in acidic pH.

1987 • 33 citations

Role of natural killer cells and macrophages in the nonspecific resistance to tumors in mice stimulated with SMANCS, a polymer-conjugated derivative of neocarzinostatin.

1990 • 31 citations

Interferon induction by SMANCS: a polymer-conjugated derivative of neocarzinostatin.

1988 • 24 citations

Stimulation of non-specific resistance to tumors in the mouse using a poly(maleic-acid-styrene)-conjugated neocarzinostatin

1989 • 12 citations

Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture.

1989 • 10 citations