The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

A stereotaxic atlas of the rat brain

1980 • 2,782 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Manual of pharmacologic calculations with computer programs

1988 • 1,456 citations

Opioid and Nonopioid Mechanisms of Stress Analgesia

1980 • 744 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Systematic examination in the rat of brain sites sensitive to the direct application of morphine: Observation of differential effects within the periaqueductal gray

1976 • 598 citations

Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat

1979 • 382 citations

Dose-dependent reductions by naloxone of analgesia induced by cold-water stress

1978 • 312 citations

Facilitation de r�actions nociceptives par la naloxone chez la souris et chez le rat

1974 • 295 citations

Immunohistochemical localization of enkephalin in rat forebrain

1980 • 267 citations

Naloxone reversal of analgesia produced by brain stimulation in the human

1976 • 261 citations

Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat

1979 • 257 citations

Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci

1977 • 239 citations

I. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat

1986 • 212 citations

Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain.

1986 • 206 citations

Molecular cloning and amino acid sequence of rat enkephalinase

1987 • 190 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION.

1964 • 173 citations

Factors governing release of methionine enkephalin-like immunoreactivity from mesencephalon and spinal cord of the cat in vivo.

1981 • 170 citations

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

1974 • 157 citations

The periaqueductal gray: Site of morphine analgesia and tolerance as shown by 2-way cross tolerance between systemic and intracerebral injections

1976 • 157 citations

Chapter 28 Sites of action of opiates in production of analgesia

1988 • 153 citations

Selective Protection of Methionine Enkephalin Released from Brain Slices by Enkephalinase Inhibition

1981 • 123 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION

1965 • 120 citations

Role of μ1-opiate receptors in supraspinal opiate analgesia: a microinjection study

1988 • 119 citations

Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site.

1988 • 119 citations

Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.

1986 • 99 citations

Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic.

1988 • 94 citations

Analgesic by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata

1978 • 74 citations

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum

1979 • 71 citations

Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors

1982 • 64 citations

Elevation of aversive threshold in rats by intra-amygdaloid injection of morphine sulphate

1977 • 62 citations

Dissociated effects of inhibitors of enkephalin-metabolising peptidase or naloxone on various nociceptive responses

1986 • 62 citations

Increased levels of met-enkephalin-like material in the CSF of anaesthetized cats after tooth pulp stimulation

1982 • 60 citations

Acute and chronic morphine modifies the in vivo release of methionine enkephalin-like immunoreactivity from the cat spinal cord and brain

1984 • 57 citations

Regional distribution of met-enkephalin within the amygdaloid complex and bed nucleus of the stria terminals

1978 • 48 citations

Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5]enkephalin

1982 • 46 citations

Enkephalinergic projection from the ventromedial hypothalamic nucleus to the midbrain central gray matter in the rat: an immunocytochemical analysis

1986 • 46 citations

Action of peptidase inhibitors on methionine5-enkephalin-arginine6-phenylalanine7 (YGGFMRF) and methionine5-enkephalin (YGGFM) metabolism and on electroacupuncture antinociception.

1984 • 38 citations

Potentiation of [D-Ala2]enkephalinamide analgesia in rats by thiorphan

1982 • 35 citations

Steady-state level and turnover rate of the tripeptide Tyr-Gly-Gly as indexes of striatal enkephalin release in vivo and their reduction during pentobarbital anesthesia.

1986 • 33 citations

Study of endogenous Tyr-Gly-Gly, a putative enkephalin metabolite, in mouse brain: Validation of a radioimmunoassay, localisation and effects of peptidase inhibitors

1985 • 26 citations

Studies on the effect of SCH-34826 and thiorphan on [Met5]enkephalin levels and release in rat spinal cord

1989 • 25 citations

Noxious stimuli and Met-enkephalin release from nucleus reticularis gigantocellularis

1984 • 24 citations

Met-enkephalin-like immunoreactivity in rat forebrain and spinal cord using hydrogen peroxide and Triton X-100. Ultrastructural study

1983 • 12 citations

Metabolism of enkephalins and its inhibition

1984 • 11 citations