Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci

Principles and procedures of statistics.

1960 • 22,587 citations

Principles and Procedures of Statistics

1961 • 18,011 citations

The rat brain: A stereotaxic atlas of the forebrain and lower parts of the brain stem

1986 • 4,155 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Purification and properties

1975 • 1,733 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon)

1974 • 1,255 citations

Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain

1974 • 1,097 citations

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the “dopamine receptor”

1972 • 1,022 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. II. Hindbrain (mesencephalon, rhombencephalon)

1974 • 799 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Noradrenergic neurons: Morphine inhibition of spontaneous activity

1974 • 433 citations

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

1974 • 417 citations

Stereospecific and Nonspecific Interactions of the Morphine Congener Levorphanol in Subcellular Fractions of Mouse Brain

1971 • 413 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

Monoaminergic mechanisms of stimulation-produced analgesia

1975 • 345 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat

1969 • 331 citations

Search for an Endogenous Ligand for the Opiate Receptor

1975 • 315 citations

Choline acetyltransferase activity and mass fragmentographic measurement of acetylcholine in specific nuclei and tracts of rat brain

1975 • 280 citations

Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose

1973 • 279 citations

Some thoughts on the significance of enkephalin, the endogenous ligand

1975 • 270 citations

Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat

1974 • 268 citations

On the central sites for the antinociceptive action of morphine and fentanyl

1970 • 265 citations

Stimulation-produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

1975 • 250 citations

Stimulation of Periaqueductal Gray and Hypothalamus

1963 • 215 citations

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

1974 • 205 citations

Projections of the nuclei of the periaqueductal gray matter in the cat

1973 • 184 citations

Distribution of stereospecific binding of the potent narcotic analgesic etorphine in the human brain: predominance in the limbic system.

1973 • 183 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION.

1964 • 173 citations

Biogenic amines and narcotic effects. I. Modification of morphine-induced analgesia and motor activity after alteration of cerebral amine levels.

1973 • 172 citations

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

1974 • 157 citations

The periaqueductal gray: Site of morphine analgesia and tolerance as shown by 2-way cross tolerance between systemic and intracerebral injections

1976 • 157 citations

Methods for Perfusing Different Structures of the Brain

1972 • 155 citations

Lamina-specific Suppression of Dorsal-horn Unit Activity by Morphine Sulfate

1974 • 150 citations

Inhibition of the jaw opening reflex by electrical stimulation of the periaqueductal gray matter in the awake, unrestrained cat

1974 • 130 citations

A COMPARISON BETWEEN ACUTE AND CHRONIC PHYSICAL DEPENDENCE IN THE CHRONIC SPINAL DOG.

1964 • 130 citations

Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission

1971 • 121 citations

STUDIES ON THE SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION

1965 • 120 citations

The analgesic effect of electrical stimulation of the diencephalon and mesencephalon

1973 • 112 citations

Analgesic Action and Brain and Plasma Levels of Morphine and Codeine in Morphine Tolerant, Codeine Tolerant and Non‐Tolerant Rats

1964 • 95 citations

The effects of morphine and pethidine on somatic evoked responses in the midbrain of the cat, and their relevance to analgesia

1962 • 93 citations

Somatosensory evoked responses in the mesencephalic central gray matter of the rat

1971 • 90 citations

Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats

1973 • 89 citations

Identification of opiate receptor binding in intact animals

1975 • 85 citations

MORPHINE AND NEUROTRANSMITTER SUBSTANCES: MICROIONTOPHORETIC STUDY IN THE RAT BRAIN STEM

1974 • 85 citations

Experience as a factor in the development of tolerance to the analgesic effect of morphine

1969 • 84 citations

Ascending catecholamine systems and morphine analgesia

1975 • 83 citations

The role of central midbrain structures in conditioned responding to aversive noise in the rat

1964 • 72 citations

Effects of midbrain central gray matter lesions on escape-avoidance behavior in rats

1968 • 72 citations

Analgesia produced by brain stimulation: Evidence of a prolonged onset period

1974 • 72 citations

The distribution of morphine following intracerebral microinjection

1966 • 70 citations

Role of midbrain central gray in pain-induced defensive boxing of rats

1974 • 69 citations

Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats

1973 • 67 citations

A COMPARISON OF DRUG EFFECTS UPON THE JAW JERK RESPONSE TO ELECTRICAL STIMULATION OF THE TOOTH PULP IN DOGS AND CATS.

1964 • 61 citations

The effect of microinjections of morphine and haloperidol into the neostriatum and the nucleus accumbens on self-stimulation behaviour.

1975 • 61 citations

Morphine analgesia, two-way avoidance, and consummatory behavior following lesions in the midbrain raphe nuclei of the rat

1974 • 58 citations

Anatomical specificity as the critical determinant of the interrelationship between raphe lesions and morphine analgesia

1975 • 50 citations

Regional sensitivity of the rat brain to the inhibitory effects of morphine on wet shake behavior.

1975 • 48 citations

Aversive thresholds following midbrain lesions.

1968 • 44 citations

[The hypothalamus and emotional behavior].

1966 • 40 citations

Autoradiographic studies concerning the supraspinal site of the antinociceptive action of morphine when inhibiting the hindleg flexor reflex in rabbits

1973 • 39 citations

Central mechanisms of pain inhibition: studies of analgesia from focal brain stimulation

1975 • 39 citations

Interaction between morphine and putative excitatory neurotransmitters in cortical neurones in naive and tolerant rats

1975 • 39 citations

Analgesic potency of sodium salicylate, indomethacin, and chlordiazepoxide as measured by the spatial preference technique in the rat

1973 • 35 citations

Opiate receptor mechanisms

1976 • 29 citations

A behavioral method for the study of pain perception in the monkey

1962 • 28 citations

Effects of brain lesions on the antinociceptive properties of morphine in rats

1975 • 25 citations

THE EFFECTS OF MORPHINE, PENTOBARBITAL, PENTAZOCINE AND NALORPHINE ON BIOELECTRICAL POTENTIALS EVOKED IN THE BRAIN STEM OF THE CAT BY ELECTRICAL STIMULATION OF THE TOOTH PULP.

1964 • 23 citations

Pain-induced alteration of glutamate in periqueductal central gray and its reversal by morphine

1974 • 17 citations

Morphine and pain: Effects on aspartate, GABA and glutamate in four discrete areas of mouse brain

1976 • 17 citations

A simple electrolytic method for cutting small-diameter stainless steel tubing

1976 • 9 citations