Increased levels of met-enkephalin-like material in the CSF of anaesthetized cats after tooth pulp stimulation

Statistical methods

1967 • 19,533 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

1979 • 1,325 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Solid-Phase Radioimmunoassay of Estradiol-17β

1969 • 837 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications

1979 • 765 citations

Opioid and Nonopioid Mechanisms of Stress Analgesia

1980 • 744 citations

Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat

1977 • 560 citations

Increased Cerebrospinal Fluid Levels of Endorphins after Electro‐Acupuncture

1977 • 452 citations

Endogenous and Exogenous Opiate Agonists and Antagonists

1980 • 442 citations

Sensory mechanisms in mammalian teeth and their supporting structures.

1970 • 316 citations

Regional distribution of methionine-enkephalin and substance P-like immunoreactivity in normal human brain and in Huntington's disease

1980 • 289 citations

Enkephalin-Like Material Elevated in Ventricular Cerebrospinal Fluid of Pain Patients After Analgetic Focal Stimulation

1978 • 262 citations

Neuropeptides and neural transmission

1980 • 252 citations

Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphine

1977 • 234 citations

Endorphins in Mental Health Research

1979 • 222 citations

ACUPUNCTURE IN HEROIN ADDICTS: CHANGES IN MET-ENKEPHALIN AND $beta;-ENDORPHIN IN BLOOD AND CEREBROSPINAL FLUID

1979 • 210 citations

Endorphins in human cerebrospinal fluid: Clinical correlations to some psychotic states

1978 • 208 citations

DEVELOPMENT OF A SPECIFIC EXTRACTED RADIOIMMUNOASSAY FOR METHIONINE ENKEPHALIN IN HUMAN PLASMA AND CEREBROSPINAL FLUID

1980 • 152 citations

Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist

1980 • 151 citations

RADIOIMMUNOASSAY OF METHIONINE‐AND LEUCINE‐ENKEPHALINS IN REGIONS OF RAT BRAIN AND COMPARISON WITH ENDORPHINS ESTIMATED BY A RADIORECEPTOR ASSAY

1978 • 149 citations

STUDIES ON THE RELIEF OF PAIN BY COUNTERIRRITATION

1941 • 140 citations

Pain in the Trigeminal Region

1978 • 135 citations

Met-enkephalin levels and opiate receptors in the spinal cord of chronic suffering rats

1980 • 131 citations

Effect of naloxone upon diffuse noxious inhibitory controls (DNIC) in the rat

1981 • 129 citations

The metabolic disposition of radiolabeled enkephalins in vitro and in situ.

1978 • 92 citations

In vivo release of met-enkephalin in the cat brain

1981 • 73 citations

Differential effects of noxious and non-noxious input on neurones according to location in ventral periaqueductal grey or dorsal raphe nucleus

1980 • 69 citations

Responses of neurons of the nucleus raphe magnus to noxious stimuli

1980 • 66 citations

Behavioral confirmation of “diffuse noxious inhibitory controls” (DNIC) and evidence for a role of endogenous opiates

1981 • 63 citations

Historical Methods of Counter-irritation

1956 • 60 citations

Enkephalin-like material in normal human CSF: Measurement and levels

1978 • 55 citations

Gel Filtration as a Method for Purification of Protein-bound Peptides Exemplified by Oxytocin and Vasopressin

1959 • 54 citations

A stable enkephalin-like immunoreactive substance in human CSF

1978 • 50 citations

Peripheral stimulation in mice induces short-duration analgesia preventable by naloxone

1979 • 44 citations

Release of methionine-enkephalin immunoreactivity from the rat spinal cord in vivo

1980 • 38 citations

Endorphins and acupuncture analgesia.

1980 • 35 citations

Chemical characteristics of endorphins in human cerebrospinal fluid

1980 • 22 citations

Enkephalin involvement in acupuncture analgesia-radioimmunoassay.

1980 • 21 citations

Significance of endorphins in endogenous antinociception.

1978 • 20 citations

Radioreceptor assay of methionine-enkephalin-like substance in human cerebrospinal fluid

1980 • 19 citations

Endorphins and acupuncture analgesia

1981 • 14 citations

Endorphins in human cerebrospinal fluid and their measurement

1979 • 10 citations

ENDORPHIN LEVELS IN THE RAT BRAIN AFTER THE TOOTH PULP STIMULATION

1980 • 4 citations

Pain is sufficient to activate the endorphin-mediated analgesia system

1980 • 4 citations

Increased release of met-enkephalin-like material (MELM) in the CSF of anaesthesized cats after tooth pulp stimulation

1981 • 1 citations