Excitatory amino acids and memory: Evidence from research on Alzheimer's disease and behavioral pharmacology

The organization of behavior

1988 • 8,668 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The organization of behavior.

1950 • 6,879 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Long-Term Potentiation

1987 • 804 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Cholinergic function and intellectual decline in Alzheimer's disease

1986 • 605 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Excitatory Amino Acid Neurotransmission: NMDA Receptors and Hebb-Type Synaptic Plasticity

1988 • 484 citations

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

Excitatory amino acid receptors in epilepsy

1990 • 428 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Glutamate dysfunction in Alzheimer's disease: an hypothesis

1987 • 335 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

The behavioral pharmacology of NMDA receptor antagonists

1990 • 331 citations

Transmitter deficits in Alzheimer's disease

1985 • 326 citations

Abuse liability of benzodiazepines.

1987 • 313 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[³H]Glutamate Binding

1987 • 281 citations

Effects of the NMDA antagonists CPP and MK-801 on radial arm maze performance in rats

1990 • 274 citations

Alzheimer's disease: a correlative study.

1986 • 269 citations

Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?

1990 • 259 citations

D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats

1989 • 253 citations

Excitatory amino acid synaptic mechanisms and neurological function

1986 • 231 citations

Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat

1988 • 225 citations

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

1988 • 222 citations

Alzheimer's disease: Glutamate depletion in the hippocampal perforant pathway zone

1987 • 221 citations

Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease

1986 • 215 citations

Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory.

1989 • 210 citations

Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

1988 • 200 citations

Alzheimer's disease: Changes in hippocampal N-methyl-d-aspartate, quisqualate, neurotensin, adenosine, benzodiazepine, serotonin and opioid receptors—an autoradiographic study

1990 • 195 citations

Behavioral effects of MK-801 mimic deficits associated with hippocampal damage

1989 • 190 citations

NON-CHOLINERGIC NEUROTRANSMITTER ABNORMALITIES IN ALZHEIMER'S DISEASE

1986 • 188 citations

NMDA receptor antagonists can enhance or impair learning performance in animals

1989 • 184 citations

MK-801 and AP5 impair acquisition, but not retention, of the Morris milk maze

1990 • 176 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Excitatory amino acid antagonists and memory: Effect of drugs acting at N-methyl-d-aspartate receptors in learning and memory tasks

1990 • 169 citations

Riluzole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils

1989 • 169 citations

Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?

1990 • 168 citations

Behavioral effects of MK-801 in the rat

1990 • 164 citations

Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat

1989 • 159 citations

Region-specific loss of glutamate innervation in Alzheimer's disease

1987 • 147 citations

A novel NMDA antagonist, MK-801, impairs performance in a hippocampal-dependent spatial learning task

1989 • 141 citations

A postmortem study of amino acid neurotransmitters in Alzheimer's disease

1986 • 134 citations

IntrathecalN-methyl-d-aspartate (NMDA) activates both nociceptive and antinociceptive systems

1987 • 130 citations

Neurotransmitters in the cerebral cortex

1986 • 127 citations

The NMDA receptor: central role in pain inhibition in rat periaqueductal gray

1988 • 118 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

Reduced Glycine Stimulation of [³H]MK‐801 Binding in Alzheimer's Disease

1989 • 117 citations

Modulation of memory processing by glutamic acid receptor agonists and antagonists

1990 • 111 citations

Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats

1989 • 110 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type

1986 • 107 citations

Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning

1990 • 101 citations

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.

1990 • 100 citations

Amnesic effect of the novel anticonvulsant MK-801

1988 • 99 citations

Loss of hippocampal [3H]TCP binding in Alzheimer's disease

1987 • 97 citations

Presynaptic and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 96 citations

Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease

1990 • 94 citations

MK-801 impedes the acquisition of a spatial memory task in rats

1990 • 92 citations

Intralaminar Neurochemical Distributions in Human Midtemporal Cortex: Comparison Between Alzheimer's Disease and the Normal

1984 • 91 citations

Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat

1985 • 90 citations

Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor

1990 • 89 citations

Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects

1990 • 86 citations

Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

1988 • 85 citations

[3H]TCP binding sites in Alzheimer's disease

1987 • 83 citations

Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.

1990 • 78 citations

Amino acid release from biopsy samples of temporal neocortex from patients with Alzheimer's disease

1983 • 77 citations

Hippocampal Free Amino Acids in Alzheimer's Disease

1980 • 74 citations

Behavioral pharmacological profile of CGS 19755, a competitive antagonist at N-methyl-D-aspartate receptors.

1989 • 73 citations

Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia.

1985 • 73 citations

The role of excitatory amino acids in neuropsychiatric illness

1990 • 70 citations

Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination

1989 • 67 citations

A preliminary study of free amino acids in the postmorten temporal cortex from Alzheimer-type dementia patients

1984 • 63 citations

Loss of glycine-dependent radioligand binding to the receptor complex in patients with Alzheimer's disease

1989 • 63 citations

Amino acid receptors and uptake systems in the mammalian central nervous system.

1988 • 61 citations

Facilitation of memory and cognition by drugs

1987 • 61 citations

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

1988 • 56 citations

Neurotransmitter dysfunction and atrophy of the caudate nucleus in Alzheimer's disease.

1984 • 55 citations

Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats

1988 • 52 citations

A glutamatergic innervation of the nucleus basalis/substantia innominata

1984 • 51 citations

Plasticity in hippocampal excitatory amino acid receptors in Alzheimer's disease

1986 • 49 citations

Differential effects of σ and phencyclidine receptor ligands on learning

1990 • 45 citations

[3H]MK-801 binding in Alzheimer's disease

1988 • 44 citations

The N-methyl-d-aspartate receptor complex in Alzheimer's disease: reduced regulation by glycine but not zinc

1989 • 44 citations

Loss of glutaminase-positive cortical neurons in Alzheimer's disease

1989 • 42 citations

Glutamatergic Abnormalities in Alzheimerʼs Disease and a Rationale for Clinical Trials with L-Glutamate

1988 • 40 citations

Characterisation, Density, and Distribution of Kainate Receptors in Normal and Alzheimer's Diseased Human Brain

1989 • 37 citations

Comprehensive handbook of psychopathology

1985 • 37 citations

Behavioral tolerance and sensitization to CGS 19755, a competitive N-methyl-D-aspartate receptor antagonist.

1988 • 36 citations

Glutamate deficits in Alzheimer's disease

1987 • 34 citations

Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

1989 • 32 citations

Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

1989 • 31 citations

Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum

1990 • 30 citations

Oxiracetam andd-pyroglutamic acid antagonize a disruption of passive avoidance behaviour induced by the N-methyl-d-aspartate receptor antagonist 2-amino-5-phosphonovalerate

1990 • 27 citations

Glutamate neurotoxicity and Alzheimer's disease

1987 • 24 citations

Systemically administered N-methyl-D-aspartate interferes with acquisition of a passive avoidance response in rats

1989 • 23 citations

Studies in presenile dementia.

1961 • 23 citations

Effect of caerulein on decreased latency of passive avoidance response in rats treated with NMDA receptor antagonists

1990 • 16 citations

Are drugs targeted at Alzheimer's disease useful? 1. Useful for what?

1990 • 14 citations

MK-801 effects on a learned food preference depend’ on dosage: Is it disruption of learning or a conditioned aversion?

1990 • 14 citations

MK-801 prevents cognitive and behavioral deficits produced by NMDA receptor overstimulation in the rat hippocampus

1989 • 14 citations

Behavioral Disorders Associated with Central Nervous System Dysfunction

1993 • 11 citations

Physiology and pathophysiology of excitatory amino acid neurotransmitter systems in relation to Alzheimer's disease.

1990 • 10 citations

Effects of l-gluutamic acid diethyl ester on discrimination learning in rats

1990 • 6 citations

Deleted Work

1955 • 0 citations