Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat

Statistical principles in experimental design.

1962 • 27,228 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Spatial localization does not require the presence of local cues

1981 • 2,665 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Anatomy of the rat

1935 • 927 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

Excitatory amino acids in the brain - focus on NMDA receptors

1987 • 641 citations

A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat

1983 • 590 citations

Hippocampal EEG and behavior: Change in amplitude and frequency of RSA (Theta rhythm) associated with spontaneous and learned movement patterns in rats and cats

1973 • 509 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool.

1985 • 270 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in rats

1987 • 261 citations

Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool.

1985 • 242 citations

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

1988 • 240 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

Formation of a place learning-set by the rat: A new paradigm for neurobehavioral studies

1985 • 209 citations

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

1987 • 194 citations

A simple model for studying benzodiazepines: Potentiation of hyperactivity induced by cocaine in mice

1982 • 193 citations

The interaction between MK-801 and receptors for : Functional consequences

1987 • 149 citations

Visits to starts, routes, and places by rats (Rattus norvegicus) in swimming pool navigation tasks.

1986 • 149 citations

MK-801 powerfully protects against N-methyl aspartate neurotoxicity

1987 • 141 citations

Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 137 citations

Systemic administration of MK-801 prevents neuronal degeneration in rat brain

1987 • 134 citations

Effects of posterior hypothalamic lesions on voluntary behavior and hippocampal electroencephalograms in the rat.

1974 • 126 citations

Hippocampal, granule cell and CA3–4 lesions impair formation of a place learning-set in the rat and induce reflex epilepsy

1987 • 117 citations

The dentate gyrus in hypoglycemia: Pathology implicating excititoxin-mediated neuronal necrosis

1985 • 113 citations

The nature and timing of excitotoxic neuronal necrosis in the cerebral cortex, hippocampus and thalamus due to flurothyl-induced status epilepticus

1988 • 113 citations

Visits to starts, routes, and places by rats (Rattus norvegicus) in swimming pool navigation tasks.

1986 • 108 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands

1988 • 99 citations

Amnesic effect of the novel anticonvulsant MK-801

1988 • 99 citations

APV, an N-methyl-d-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats

1988 • 91 citations

Phencyclidine-like discriminative stimulus properties of MK-801 in rats

1988 • 82 citations

Selective memory impairment by phencyclidine in rats

1987 • 77 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Mode of action of excitatory amino acid receptor antagonists on hippocampal long-lasting potentiation

1986 • 74 citations

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine

1987 • 71 citations

Differential effects of competitive and non-competitive antagonists on glucose use in the limbic system

1988 • 63 citations

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

1986 • 54 citations

The effects of repeated induction of long-term potentiation in the dentate gyrus

1985 • 53 citations

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate

1986 • 38 citations

Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: Structure-activity studies☆

1987 • 20 citations

Suppression of serotonin-dependent cerebral activation: a possible mechanism of action of some psychotomimetic drugs

1987 • 16 citations