Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

1993 • 730 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

1994 • 685 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule

1995 • 427 citations

Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons

1995 • 382 citations

Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF

1992 • 346 citations

Macrophage dependence of peripheral sensory nerve regeneration: Possible involvement of nerve growth factor

1991 • 296 citations

Inflammation near the nerve cell body enhances axonal regeneration

1991 • 279 citations

Induction of interleukin-6 in axotomized sensory neurons

1995 • 273 citations

Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

1994 • 268 citations

Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats

1994 • 260 citations

Interleukin‐6 Production by Schwann Cells and Induction in Sciatic Nerve Injury

1995 • 254 citations

Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons

1993 • 244 citations

Ephaptic transmission in chronically damaged peripheral nerves

1979 • 241 citations

Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones

1995 • 220 citations

Sensory nerves in adult rats regenerate and restore sensory function to the skin independently of endogenous NGF

1992 • 191 citations

Expression of mRNA for neurotrophic factors and their receptors in the rat dorsal root ganglion and sciatic nerve following nerve injury

1993 • 180 citations

Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain

1994 • 176 citations

An animal model of neuropathic pain: A review

1993 • 166 citations

Nerve growth factor receptors on normal and injured sensory neurons

1989 • 165 citations

Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury

1997 • 156 citations

Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat

1991 • 153 citations

Update of the NGF saga

1995 • 152 citations

Antinociceptive effects of acute and ‘chronic’ injections of tricyclic antidepressant drugs in a new model of mononeuropathy in rats

1992 • 149 citations

Pain due to nerve damage: Are inflammatory mediators involved

1995 • 145 citations

Pathology of Experimental Compression Neuropathy Producing Hyperesthesia

1993 • 138 citations

Delayed Wallerian degeneration in sciatic nerves of C57BL/Ola mice is associated with impaired regeneration of sensory axons

1990 • 128 citations

Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons

1984 • 125 citations

Reduced Hyperalgesia in Nerve-Injured WLD Mice: Relationship to Nerve Fiber Phagocytosis, Axonal Degeneration, and Regeneration in Normal Mice

1996 • 124 citations

Increased NGF mRNA expression in denervated rat skin

1993 • 111 citations

Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy

1991 • 102 citations

Alterations in myelinated fibres in the sciatic nerve of rats after constriction: possible relationships between the presence of abnormal small myelinated fibres and pain-related behaviour

1990 • 100 citations

Afterdischarge and interactions among fibers in damaged peripheral nerve in the rat

1987 • 99 citations

Nerve growth factor‐induced sprouting of mature, uninjured sympathetic axons

1992 • 93 citations

Overexpression of nerve growth factor in transgenic mice induces novel sympathetic projections to primary sensory neurons

1994 • 91 citations

Time course of degeneration and regeneration of myelinated nerve fibres following chronic loose ligatures of the rat sciatic nerve: can nerve lesions be linked to the abnormal pain-related behaviours?

1993 • 91 citations

Sympathetic nerves in adult rats regenerate normally and restore pilomotor function during an anti‐NGF treatment that prevents their collateral sprouting

1992 • 89 citations

Sympathetic modulation of activity in rat dorsal root ganglion neurons changes over time following peripheral nerve injury

1996 • 89 citations

Peripheral hyperalgesia in experimental neuropathy: mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals

1995 • 88 citations

Imparied motor axon regeneration in the C57BL/Ola mouse

1993 • 79 citations

Substance P gene expression is regulated by interleukin‐1 in cultured sympathetic ganglia

1991 • 78 citations

Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain

1993 • 69 citations

Intraventricular NGF infusion in the mature rat brain enhances sympathetic innervation of cerebrovascular targets but fails to elicit sympathetic ingrowth

1989 • 67 citations

Influence of the sympathetic nervous system in the development of abnormal pain-related behaviours in a rat model of neuropathic pain

1995 • 65 citations

Interleukin‐2 enhances chick and rat sympathetic, but not sensory, neurite outgrowth

1990 • 65 citations

Tumor necrosis factor‐α induces substance P in sympathetic ganglia through sequential induction of interleukin‐1 and leukemia inhibitory factor

1995 • 57 citations

The resolution of neuropathic hyperalgesia following motor and sensory functional recovery in sciatic axonotmetic mononeuropathies

1994 • 56 citations

Close apposition among neighbouring axonal endings in a neuroma

1993 • 51 citations

Neurotransmitters in the spinal cord dorsal horn in a model of painful neuropathy and in nerve crush

1995 • 46 citations

LIF-mediated activation of STAT proteins after neuronal injury in vivo

1995 • 45 citations

Bilateral phasic increases in dorsal root ganglia nerve growth factor synthesis after unilateral sciatic nerve crush

1994 • 39 citations

Cell body response to injury in motoneurons and primary sensory neurons of a mutant mouse, ola (Wld), in which wallerian degeneration is delayed

1995 • 33 citations

IL-6 increases choline acetyltransferase but not neuropeptide transcripts in sympathetic neurons

1994 • 29 citations

LIF-and IL-1β-mediated increases in substance P receptor mRNA in axotomized, explanted or dissociated sympathetic ganglia

1995 • 29 citations

Effects of Exogenous Nerve Growth Factor upon Sympathetic Sprouting into the Hippocampal Formation

1995 • 22 citations

Pretreatment with Interleukin-1 Enhances Survival of Sympathetic Ganglionic Neuron Grafts

1994 • 15 citations