Somatic Mutation in Anti‐Phosphorylcholine Antibodies

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Somatic mutation and the maturation of immune response to 2-phenyl oxazolone

1984 • 534 citations

IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts

1981 • 509 citations

A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibody

1981 • 470 citations

Molecular Basis of Mutation

1970 • 349 citations

Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity.

1984 • 344 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

1985 • 319 citations

Analysis of the repertoire of anti‐NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

1978 • 316 citations

Origin of Antibody Variation

1966 • 314 citations

mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification

1983 • 301 citations

Analysis of the repertoire of anti‐(4‐hydroxy‐3‐nitro‐phenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti‐idiotope antibodies

1979 • 254 citations

Clusters of point mutations are found exclusively around rearranged antibody variable genes.

1983 • 233 citations

Somatic evolution of variable region structures during an immune response.

1986 • 211 citations

Somatic mutation of immunoglobulin light-chain variable-region genes

1981 • 184 citations

Fidelity of Mammalian DNA Polymerases

1981 • 180 citations

Patterns of Somatic Mutations in Immunoglobulin Variable Genes

1987 • 158 citations

The Generation of Diversity in Phosphorylcholine-Binding Antibodies

1984 • 153 citations

Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line.

1985 • 150 citations

One heavy chain variable region gene segment subfamily in the BALBc mouse contains 500–1000 or more members

1986 • 132 citations

Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity.

1987 • 132 citations

Organization of four mouse lambda light chain immunoglobulin genes.

1981 • 127 citations

VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules.

1984 • 123 citations

Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region Genes

1984 • 120 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

Mutations in Immunoglobulin-Producing Moose Myeloma Cells

1973 • 99 citations

Unique Self-complementarity of Palindromic Sequences Provides DNA Structural Intermediates for Mutation

1983 • 93 citations

Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies.

1983 • 74 citations

Somatic Mutations of Immunoglobulin Variable Genes Are Restricted to the Rearranged V Gene

1983 • 63 citations

Enzymes involved in the repair of damaged DNA

1981 • 61 citations

Size differences among immunoglobulin heavy chains from phosphorylcholine-binding proteins.

1976 • 61 citations

The Structure and Genetics of Mouse Immunoglobulins: An Analysis of NZB Myeloma Proteins and Sets of BALB/c Myeloma Proteins Binding Particular Haptens

1977 • 58 citations

The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl(NP) antibodies

1979 • 57 citations

Generation of immunoglobulin variable gene diversity

1982 • 52 citations

Nucleotide sequences of five anti-lysozyme monoclonal antibodies.

1985 • 46 citations

Nucleic acid and protein sequences of phosphocholine-binding light chains.

1981 • 45 citations

Preferential rearrangement of the immunoglobulin kappa chain joining region J kappa 1 and J kappa 2 segments in mouse spleen DNA.

1985 • 45 citations

Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.

1981 • 42 citations

The cross-reactive idiotype of A-strain mice Serological and structural analyses

1982 • 40 citations

Kappa chain structure from a crystallized murine Fab′: Role of joining segment in hapten binding

1981 • 38 citations

Several V genes participate in the early phenyloxazolone response in various combinations

1986 • 35 citations

Synthesis, Structure, and Integration of the DNA of RNA Tumor Viruses

1979 • 30 citations

Two monoclonal antibodies against different antigens using the same VH germ-line gene

1983 • 29 citations

The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6

1986 • 27 citations

Spontaneous Mutation in Man

1970 • 24 citations

κ Chain variable region from M167, a phosphorylcholine binding myeloma protein

1978 • 22 citations

Analysis of heterogeneous dissociation kinetics in polyclonal populations of rabbit anti-fluorescyl-IgG antibodies

1983 • 19 citations

Structural studies on induced antibodies with defined idiotypic specificities. III. N-terminal amino acid sequence of the heavy and light chains of mouse anti-streptococcal antibodies--A5A, S8, and S117.

1976 • 19 citations

The immune response of BALB/c mice to phosphorylcholine is restricted to a limited number of VH- and VL-isotypes

1981 • 17 citations

Quantitative representation of two germ‐line V genes in the early antibody response to 2‐phenyloxazolone

1986 • 12 citations

The role of a novel VH sequence (V11) in the formation of anti-phosphocholine antibodies

1984 • 2 citations