Membrane-embedded Synaptotagmin Penetrates cis ortrans Target Membranes and Clusters via a Novel Mechanism

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Photophysics of aromatic molecules

1971 • 4,490 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Photophysics of aromatic molecules

1970 • 3,359 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

1994 • 1,485 citations

Small-volume extrusion apparatus for preparation of large, unilamellar vesicles

1991 • 1,461 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

1992 • 968 citations

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

1990 • 829 citations

Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

1994 • 798 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

1981 • 704 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Parallax method for direct measurement of membrane penetration depth utilizing fluorescence quenching by spin-labeled phospholipids

1987 • 671 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

Molecular dynamics simulation of a bilayer of 200 lipids in the gel and in the liquid crystal phase

1993 • 473 citations

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1995 • 455 citations

Timing of neurotransmission at fast synapses in the mammalian brain

1996 • 432 citations

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1

1995 • 372 citations

Domain structure of synaptotagmin (p65)

1991 • 350 citations

Two Vesicle-associated Membrane Protein Genes Are Differentially Expressed in the Rat Central Nervous System

1989 • 326 citations

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

1998 • 313 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.

1994 • 286 citations

Kinetics of Synaptotagmin Responses to Ca2+ and Assembly with the Core SNARE Complex onto Membranes

1999 • 277 citations

Direct Interaction of a Ca2+-binding Loop of Synaptotagmin with Lipid Bilayers

1998 • 259 citations

The effect on synaptic physiology of synaptotagmin mutations in drosophila

1994 • 253 citations

Structure and function of fusion pores in exocytosis and ectoplasmic membrane fusion

1995 • 249 citations

The C Terminus of SNAP25 Is Essential for Ca2+-dependent Binding of Synaptotagmin to SNARE Complexes

2000 • 241 citations

Solution Structures of the Ca²⁺-free and Ca²⁺-bound C₂A Domain of Synaptotagmin I: Does Ca²⁺ Induce a Conformational Change?

1998 • 221 citations

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

1994 • 209 citations

A Novel Function for the Second C2 Domain of Synaptotagmin

1996 • 197 citations

Mechanism of Phospholipid Binding by the C₂A-Domain of Synaptotagmin I

1998 • 191 citations

Determination of the depth of bromine atoms in bilayers formed from bromolipid probes

1987 • 173 citations

Transmembrane Orientation of Hydrophobic α-Helices Is Regulated Both by the Relationship of Helix Length to Bilayer Thickness and by the Cholesterol Concentration

1997 • 163 citations

Distinct Ca2+-dependent Properties of the First and Second C2-domains of Synaptotagmin I

1996 • 137 citations

Calibration of the parallax fluorescence quenching method for determination of membrane penetration depth: refinement and comparison of quenching by spin-labeled and brominated lipids

1992 • 96 citations

Fatty Acylation of Synaptotagmin in PC12 Cells and Synaptosomes

1996 • 73 citations

Lipid Binding Ridge on Loops 2 and 3 of the C2A Domain of Synaptotagmin I as Revealed by NMR Spectroscopy

1998 • 44 citations

Glycosylation and transmembrane topography of bovine chromaffin granule p65

1991 • 24 citations