Modelling telomere shortening and the role of oxidative stress

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere states and cell fates

2000 • 1,359 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

Long G Tails at Both Ends of Human Chromosomes Suggest a C Strand Degradation Mechanism for Telomere Shortening

1997 • 897 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood

1999 • 719 citations

Normal human chromosomes have long G-rich telomeric overhangs at one end

1997 • 707 citations

The rate of telomere sequence loss in human leukocytes varies with age

1998 • 652 citations

[Principle of marginotomy in template synthesis of polynucleotides].

1971 • 566 citations

Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

2000 • 532 citations

Role of Oxidative Stress in Telomere Length Regulation and Replicative Senescence

2000 • 430 citations

Preferential Accumulation of Single-Stranded Regions in Telomeres of Human Fibroblasts

1998 • 414 citations

Telomeres, telomerase, and aging: Origin of the theory

1996 • 410 citations

Evidence for a New Step in Telomere Maintenance

1996 • 304 citations

Short Telomeres in Patients with Vascular Dementia: An Indicator of Low Antioxidative Capacity and a Possible Risk Factor?

2000 • 302 citations

Intraclonal Variation in Proliferative Potential of Human Diploid Fibroblasts: Stochastic Mechanism for Cellular Aging

1980 • 290 citations

Telomere Shortening Is Proportional to the Size of the G-rich Telomeric 3′-Overhang

2000 • 266 citations

Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative Senescence

2000 • 254 citations

Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments

1999 • 178 citations

Accelerated Telomere Shortening in Fibroblasts After Extended Periods of Confluency

1998 • 165 citations

A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA

2001 • 115 citations

Stochastic Mechanism of Cellular Aging—Abrupt Telomere Shortening as a Model for Stochastic Nature of Cellular Aging

1999 • 97 citations

Aging under glass

1991 • 54 citations

Mathematical modeling of the loss of telomere sequences

1995 • 54 citations

Telomere Length Distribution and Southern Blot Analysis

1998 • 48 citations

Intramitotic and Intraclonal Variation in Proliferative Potential of Human Diploid Cells: Explained by Telomere Shortening

1999 • 26 citations

Simulated shortening of proliferation-restricting telomeres during clonal proliferation and senescence of human cells

2001 • 9 citations