TNF-α Gene Expression in Macrophages: Regulation by NF-κB Is Independent of c-Jun or C/EBPβ

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

1997 • 725 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Lipopolysaccharide Induction of the Tumor Necrosis Factor-α Promoter in Human Monocytic Cells

1997 • 466 citations

Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain

1993 • 345 citations

Synergistic transcriptional activation of the IL-8 gene by NF-kappa B p65 (RelA) and NF-IL-6.

1994 • 327 citations

Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.

1998 • 325 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Regulation of an essential innate immune response by the p50 subunit of NF-kappaB.

1998 • 278 citations

Regulation of Monocyte IL-10 Synthesis by Endogenous IL-1 and TNF-α: Role of the p38 and p42/44 Mitogen-Activated Protein Kinases

1998 • 270 citations

In Vitro Cellular Drug Resistance and Prognosis in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia

1997 • 266 citations

Inhibition of MAP Kinase Kinase Prevents Cytokine and Prostaglandin E2 Production in Lipopolysaccharide-Stimulated Monocytes

1998 • 255 citations

Tumor Necrosis Factor Alpha Gene Regulation in Activated T Cells Involves ATF-2/Jun and NFATp

1996 • 252 citations

Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent

1998 • 251 citations

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.

1992 • 210 citations

Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-κB p50

1998 • 180 citations

C/EBP beta regulation of the tumor necrosis factor alpha gene.

1994 • 173 citations

Similarities and Differences Between Human and Murine TNF Promoters in Their Response to Lipopolysaccharide

1999 • 150 citations

ETS1, NFκB and AP1 synergistically transactivate the human GM – CSF promoter

1997 • 145 citations

Human tumor necrosis factor alpha gene regulation in phorbol ester stimulated T and B cell lines.

1991 • 138 citations

Regulation of the Tissue Factor Gene in Human Monocytic Cells

1997 • 137 citations

Genetic analysis of the human tumor necrosis factor alpha/cachectin promoter region in a macrophage cell line.

1989 • 122 citations

Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human Monocytes

1998 • 122 citations

Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site

1994 • 118 citations

Tumor Necrosis Factor Alpha Gene Regulation: Enhancement of C/EBPβ-Induced Activation by c-Jun

1998 • 117 citations

Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization.

1990 • 116 citations

Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B.

1997 • 85 citations

Adenovirus-Mediated Expression of a Dominant Negative Mutant of p65/RelA Inhibits Proinflammatory Gene Expression in Endothelial Cells Without Sensitizing to Apoptosis

1998 • 82 citations

Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a kappa B-like site.

1994 • 68 citations

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

1991 • 61 citations

Microbial superantigens induce NF-kappa B in the human monocytic cell line THP-1.

1993 • 55 citations

Functional dissection of adenovirus VAI RNA

1989 • 54 citations

Autocrine Signals Control CCAAT/Enhancer Binding Protein β Expression, Localization, and Activity in Macrophages

1998 • 49 citations

CCAAT/ENHANCER BINDING PROTEIN IS INVOLVED IN THE EXPRESSION OF THE TUMOUR NECROSIS FACTOR GENE IN HUMAN MONOCYTES

1996 • 42 citations

Enhanced cytotoxicity in the rheumatoid joint

1990 • 4 citations

Autocrine Signals Control CCAAT/Enhancer Binding Protein β Expression, Localization, and Activity in Macrophages

1998 • 3 citations