Mice transgenic for intracellular interleukin‐1 receptor antagonist type 1 are protected from collagen‐induced arthritis

Cloning of a new cytokine that induces IFN-γ production by T cells

1995 • 2,584 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology

1998 • 1,048 citations

Nucleotide sequence of human monocyte interleukin 1 precursor cDNA.

1984 • 1,042 citations

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist

1998 • 956 citations

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

2000 • 713 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

1991 • 262 citations

The intracellular IL-1 receptor antagonist alters IL-1-inducible gene expression without blocking exogenous signaling by IL-1 beta.

1995 • 89 citations

Characterization of a Low Molecular Weight Isoform of IL-1 Receptor Antagonist

1998 • 89 citations

Altered susceptibility to collagen-induced arthritis in transgenic mice with aberrant expression of interleukin-1 receptor antagonist

1998 • 68 citations

Phagocytic lining cells determine local expression of inflammation in type II collagen–induced arthritis

1996 • 67 citations

Direct binding enzyme-linked immunosorbent assay (ELISA) for serum amyloid A (SAA)

1989 • 62 citations

Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo

2001 • 58 citations

Extracellular release of the type I intracellular IL-1 receptor antagonist from human airway epithelial cells: differential effects of IL-4, IL-13, IFN-gamma, and corticosteroids.

1997 • 57 citations

Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: A possible role in the resolution of arthritis

2001 • 48 citations

Rhinovirus Regulation of IL-1 Receptor Antagonist In Vivo and In Vitro: A Potential Mechanism of Symptom Resolution

1999 • 48 citations

Characterization of type II intracellular IL-1 receptor antagonist (IL-1ra3): a depot IL-1ra

1999 • 32 citations

IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis

2000 • 22 citations

Processing, Secretion, and Anti-HIV-1 Activity of IL-16 With or Without a Signal Peptide in CD4+ T Cells

1999 • 19 citations