The Fas-associated death domain protein suppresses activation of NF-κB by LPS and IL-1β

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 • 1,905 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 • 893 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Endotoxemia in Human Septic Shock

1991 • 656 citations

Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

1999 • 650 citations

Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells

2000 • 556 citations

c-JUN, JUN B, and JUN D differ in their binding affinities to AP-1 and CRE consensus sequences: effect of FOS proteins.

1991 • 543 citations

Interleukin 20

2001 • 542 citations

The apoptotic signaling pathway activated by Toll-like receptor-2

2000 • 487 citations

Trends in Infectious Diseases Mortality in the United States

1996 • 469 citations

The T Cell Activation Factor NF-ATc Positively Regulates HIV-1 Replication and Gene Expression in T Cells

1997 • 313 citations

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6

2000 • 297 citations

Activation of NF-κB by FADD, Casper, and Caspase-8

2000 • 291 citations

Drosophila MyD88 is an adapter in the Toll signaling pathway

2001 • 262 citations

Activation of the NF-κB pathway by Caspase 8 and its homologs

2000 • 234 citations

A Phosphatidylinositol 3-Kinase/Akt Pathway, Activated by Tumor Necrosis Factor or Interleukin-1, Inhibits Apoptosis but Does Not Activate NFκB in Human Endothelial Cells

2000 • 209 citations

Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells

2000 • 200 citations

Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)

2000 • 183 citations

Lipopolysaccharide Mediates Endothelial Apoptosis by a FADD-dependent Pathway

1998 • 150 citations

A Critical Role for the RelA Subunit of Nuclear Factor κB in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death

1999 • 147 citations

Regulatory Roles for CD14 and Phosphatidylinositol in the Signaling via Toll-like Receptor 4-MD-2

2000 • 144 citations

Modulation of the Nuclear Factor κb Pathway by Shp-2 Tyrosine Phosphatase in Mediating the Induction of Interleukin (Il)-6 by IL-1 or Tumor Necrosis Factor

2001 • 130 citations

Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.

1999 • 123 citations

Inhibition of Phosphatidylinositol 3-Kinase Induces Nitric-oxide Synthase in Lipopolysaccharide- or Cytokine-stimulated C6 Glial Cells

1999 • 120 citations

Trends in infectious diseases mortality in the United States

1996 • 109 citations

A Constitutive Cytoprotective Pathway Protects Endothelial Cells from Lipopolysaccharide-induced Apoptosis

2001 • 109 citations

Tumor Suppressor MMAC/PTEN Inhibits Cytokine-induced NFκB Activation without Interfering with the IκB Degradation Pathway

2001 • 89 citations

Interleukin-1/Toll Receptor Family Members: Receptor Structure and Signal Transduction Pathways

2000 • 81 citations

NF-κB Activation Is Required for Human Endothelial Survival during Exposure to Tumor Necrosis Factor-α but Not to Interleukin-1β or Lipopolysaccharide

1999 • 80 citations

Lipopolysaccharide-Induced NF-κB Activation in Human Endothelial Cells Involves Degradation of IκBα but Not IκBβ

1998 • 34 citations